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@article{Teh:2021:10.1039/d1cc04790f,
author = {Teh, JH and Braga, M and Allott, L and Barnes, C and Hernandez-Gil, J and Tang, M-X and Aboagye, EO and Long, NJ},
doi = {10.1039/d1cc04790f},
journal = {Chemical Communications},
pages = {11677--11680},
title = {A kit-based aluminium-[F-18]fluoride approach to radiolabelled microbubbles},
url = {http://dx.doi.org/10.1039/d1cc04790f},
volume = {57},
year = {2021}
}

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TY  - JOUR
AB  - The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40–50% RCY), which was incorporated into MBs (40–50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.
AU  - Teh,JH
AU  - Braga,M
AU  - Allott,L
AU  - Barnes,C
AU  - Hernandez-Gil,J
AU  - Tang,M-X
AU  - Aboagye,EO
AU  - Long,NJ
DO  - 10.1039/d1cc04790f
EP  - 11680
PY  - 2021///
SN  - 1359-7345
SP  - 11677
TI  - A kit-based aluminium-[F-18]fluoride approach to radiolabelled microbubbles
T2  - Chemical Communications
UR  - http://dx.doi.org/10.1039/d1cc04790f
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000709440700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/CC/D1CC04790F
UR  - http://hdl.handle.net/10044/1/101072
VL  - 57
ER  -

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