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@article{Aboagye:2022:10.1039/D2RA04535D,
author = {Aboagye, E and Brickute, D and Allott, L and Wang, N and Barnes, C and Costa-Braga, M and Chen, C},
doi = {10.1039/D2RA04535D},
journal = {RSC Advances: an international journal to further the chemical sciences},
pages = {26372--26381},
title = {Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells},
url = {http://dx.doi.org/10.1039/D2RA04535D},
volume = {12},
year = {2022}
}

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TY  - JOUR
AB  - Promoting a senescent phenotype to supress tumour progression may present an alternative strategy for treating cancerand encourages the development of positron emission tomography (PET) imaging biomarkers for assessing response totreatment. The accumulation of lipofuscin deposits in senescent cells are visualised using the pathology stain Sudan Black B(SBB) and is an emerging biomarker of senescence. We describe the design, synthesis and evaluation of[18F]fluoroethyltriazole-SBB ([18F]FET-SBB), a fluorine-18 radiolabelled derivative of SBB. The in vitro uptake of [18F]FET-SBBin a senescent cell line corelated with lipofuscin deposits; in vivo PET imaging and metabolite analysis confirms a favourablepharmacokinetic and metabolic profile for futher studies of in vivo models of senescence.
AU  - Aboagye,E
AU  - Brickute,D
AU  - Allott,L
AU  - Wang,N
AU  - Barnes,C
AU  - Costa-Braga,M
AU  - Chen,C
DO  - 10.1039/D2RA04535D
EP  - 26381
PY  - 2022///
SN  - 2046-2069
SP  - 26372
TI  - Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells
T2  - RSC Advances: an international journal to further the chemical sciences
UR  - http://dx.doi.org/10.1039/D2RA04535D
UR  - https://pubs.rsc.org/en/content/articlelanding/2022/RA/D2RA04535D
UR  - http://hdl.handle.net/10044/1/99630
VL  - 12
ER  -

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