Publications
302 results found
Sadri A, Karunanantham J, Song F, et al., 2010, After induction treatment, radiotherapy is not superior to surgery for N2 disease: A meta-analysis of randomised trials, LUNG CANCER, Vol: 67, Pages: S38-S38, ISSN: 0169-5002
Spiro SG, Tanner NT, Silvestri GA, et al., 2010, Lung cancer: Progress in diagnosis, staging and therapy, RESPIROLOGY, Vol: 15, Pages: 44-50, ISSN: 1323-7799
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- Citations: 76
Pattenden H, Karunanantham J, Leung M, et al., 2010, Functional outcome in patients with non-small cell lung cancer who failed BTS recommended post-operative predicted criteria for lung resection, LUNG CANCER, Vol: 67, Pages: S37-S37, ISSN: 0169-5002
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- Citations: 1
Faivre-Finn C, Kerr K, Macfie A, et al., 2010, Guidelines on the radical management of patients with lung cancer, Thorax
Kho P, Karunanantham J, Leung M, et al., 2009, DEBRIDEMENT ALONE WITHOUT DECORTICATION CAN ACHIEVE LUNG RE-EXPANSION IN PATIENTS WITH EMPYEMA: AN OBSERVATIONAL STUDY, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A68-A69, ISSN: 0040-6376
Lim E, Harris G, Patel A, et al., 2009, Preoperative versus Postoperative Chemotherapy in Patients with Resectable Non-small Cell Lung Cancer <i>Systematic Review and Indirect Comparison Meta</i>-<i>Analysis of Randomized Trials</i>, JOURNAL OF THORACIC ONCOLOGY, Vol: 4, Pages: 1380-1388, ISSN: 1556-0864
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- Citations: 121
Adams K, Shah PL, Edmonds, et al., 2009, Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis., Thorax, Vol: 9, Pages: 757-762
BACKGROUND: Endobronchial ultrasound (EBUS) with transbronchial needle aspiration (TBNA) is becoming widely used for mediastinal lymph node staging in patients with known or suspected lung cancer. While a substantial number of case series have evaluated test performance of this investigation, the small sample sizes limited the ability to accurately evaluate the precision of EBUS-TBNA as a staging modality. A systematic review was performed of published studies evaluating EBUS-TBNA for mediastinal lymph node staging to ascertain the pooled sensitivity and specificity of this investigation. METHODS: A literature search was constructed and performed by a professional medical librarian to identify the literature from 1960 to February 2008. Pooled specificity and sensitivity was estimated from the extracted data with an exact binomial rendition of the bivariate mixed-effects regression model. RESULTS: Of 365 publications, 25 were identified in which EBUS-TBNA was specifically focused on mediastinal node staging. Of these, only 10 had data suitable for extraction and analysis. The overall test performance was excellent with an area under the summary receiver operating characteristics curve of 0.99 (95% CI 0.96 to 1.00); similarly, EBUS-TBNA had excellent pooled specificity of 1.00 (95% CI 0.92 to 1.00) and good pooled sensitivity of 0.88 (95% CI 0.79 to 0.94). CONCLUSIONS: EBUS-TBNA has excellent overall test performance and specificity for mediastinal lymph node staging in patients with lung cancer. The results compare favourably with published results for computed tomography and positron emission tomography.
Rizvi SMH, Goodwill J, Lim E, et al., 2009, The frequency of neuroendocrine cell hyperplasia in patients with pulmonary neuroendocrine tumours and non-neuroendocrine cell carcinomas, HISTOPATHOLOGY, Vol: 55, Pages: 332-337, ISSN: 0309-0167
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- Citations: 23
Ding W-H, Lam Y-Y, Duncan A, et al., 2009, Predictors of survival after aortic valve replacement in patients with low-flow and high-gradient aortic stenosis, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 11, Pages: 897-902, ISSN: 1388-9842
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- Citations: 22
Lim E, Clough R, Goldstraw P, et al., 2009, Impact of positive pleural lavage cytology on survival in patients undergoing lung resection for non-small cell lung cancer: An international multicenter study., J Clin Oncol, Vol: 27
7519 Background: Pleural lavage cytology (PLC) is the instillation of saline into the chest during surgery for non-small cell lung cancer (NSCLC). The aims of this study were to collate multi-institutional individual patient data to determine independence as a prognostic marker and characterise impact of positive results on stage adjusted survival. METHODS: We identified 31 publications from 22 centers/research groups that performed pleural lavage cytology during surgery for NSCLC and invited submission of individual patient data. Actuarial survival was calculated using Kaplan Meier methods and comparisons were performed using the log-rank test. Cox proportional hazards regression was utilised to ascertain the covariates associated with survival. RESULTS: By 1 January 2008, submissions were received internationally from 11 centers with individual data from 8763 patients. In total, 511 (5.8%) patients had a positive pleural lavage cytology result, and this was shown to be an independent predictor of adverse survival associated with a hazard ratio of 1.465 (1.290 - 1.665; P<0.001). On statistical modelling, the best adjustment for patients with a positive PLC result was a single increase in the T category assigned to the case, up to a maximum of T4. Correction for differences in survival were obtained in stage IB (P=0.315) and IIB (P=0.453), with a degree of correction in stage IIIA (P=0.07). CONCLUSIONS: Pleural lavage cytology should be considered in all patients with NSCLC suitable for resection. A positive result is an independent predictor of adverse survival and the impact on survival suggests that it may be appropriate to upstage patients by one T category. No significant financial relationships to disclose.
Lim E, Clough R, Goldstraw P, 2009, Impact of positive pleural lavage cytology on survival in patients undergoing lung resection for non-small cell lung cancer: An international multicenter study, 45th Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Lim E, 2009, Is it Time to Reevaluate the Role of Surgery in Small Cell Lung Cancer? Response, JOURNAL OF THORACIC ONCOLOGY, Vol: 4, Pages: 669-669, ISSN: 1556-0864
Sarraf KM, Belcher E, Raevsky E, et al., 2009, Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 137, Pages: 425-428, ISSN: 0022-5223
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- Citations: 441
Lim E, 2009, Response to letter to the editor, Journal of Thoracic Oncology, Vol: 4, ISSN: 1556-0864
Lim E, Dusmet M, 2009, Remediastinoscopy: a statistical reinterpretation, J Thorac Cardiovasc Surg, Vol: 137, Pages: 254-255, ISSN: 0022-5223
Lim E, Clough R, Goldstraw P, 2009, Impact of positive pleural lavage cytology on survival in patients undergoing lung resection for NSCLC, LUNG CANCER, Vol: 63, Pages: S17-S17, ISSN: 0169-5002
Adams K, Shah P, Edmond L, et al., 2009, Endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with non-small cell lung cancer: systematic review and meta-analysis, LUNG CANCER, Vol: 63, Pages: S21-S22, ISSN: 0169-5002
Raftery AT, Lim EKS, Östör AJK, 2009, Churchill's Pocketbook of Differential Diagnosis, Publisher: Churchill Livingstone, ISBN: 9780702032226
The Third Edition of this best-selling book is packed full of information to help thereader move from a presenting problem to an accurate diagnosis.
Sarraf KM, Belcher E, Raevsky E, et al., 2008, NEUTROPHIL TO LYMPHOCYTE RATIO AND ITS ASSOCIATION WITH SURVIVAL AFTER COMPLETE RESECTION IN NON-SMALL-CELL LUNG CANCER, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A61-A61, ISSN: 0040-6376
Edmonds L, Adams KJ, Shah P, et al., 2008, TEST PERFORMANCE OF ENDOBRONCHIAL ULTRASOUND AND TRANSBRONCHIAL NEEDLE ASPIRATION BIOPSY FOR MEDIASTINAL STAGING IN PATIENTS WITH LUNG CANCER: SYSTEMATIC REVIEW AND META-ANALYSIS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A68-A68, ISSN: 0040-6376
Lim E, Brown A, Helmy A, et al., 2008, Composite Outcomes in Cardiovascular Research: A Survey of Randomized Trials, ANNALS OF INTERNAL MEDICINE, Vol: 149, Pages: 612-+, ISSN: 0003-4819
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- Citations: 76
Lim E, Belcher E, Khoong Y, et al., 2008, The Role of Surgery in the Treatment of Limited Disease Small Cell Lung Cancer Time to Reevaluate, JOURNAL OF THORACIC ONCOLOGY, Vol: 3, Pages: 1267-1271, ISSN: 1556-0864
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- Citations: 100
Lim E, Goldstraw P, Nicholson AG, et al., 2008, Proceedings of the IASLC International Workshop on Advances in Pulmonary Neuroendocrine Tumors 2007, JOURNAL OF THORACIC ONCOLOGY, Vol: 3, Pages: 1194-1201, ISSN: 1556-0864
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- Citations: 58
Sarraf KM, Belcher E, Price S, et al., 2008, Clinical application of direct bronchial ultrasound to visualize and determine endobronchial tumor margins for surgical resection, ANNALS OF THORACIC SURGERY, Vol: 86, Pages: 1339-1342, ISSN: 0003-4975
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- Citations: 4
Lim E, Ali A, Theodorou P, et al., 2008, Longitudinal study of the profile and predictors of left ventricular mass regression after stentless aortic valve replacement, ANNALS OF THORACIC SURGERY, Vol: 85, Pages: 2026-2029, ISSN: 0003-4975
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- Citations: 45
Lim E, Harris G, Patel A, et al., 2008, Preoperative versus postoperative chemotherapy in patients with resectable non-small cell lung cancer: Systematic review and indirect comparison meta-analysis of randomized trials, JOURNAL OF CLINICAL ONCOLOGY, Vol: 26, ISSN: 0732-183X
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- Citations: 9
Sarraf K, Belcher E, Raevsky E, et al., 2008, Increasing preoperative neutrophil to lymphocyte ratio: An independent predictor of adverse survival after pulmonary resection of non-small cell lung cancer, JOURNAL OF CLINICAL ONCOLOGY, Vol: 26, ISSN: 0732-183X
Sarraf K, Belcher E, Raevsky E, et al., 2008, Increasing preoperative neutrophil to lymphocyte ratio - an independent predictor of adverse survival after pulmonary resection of NSCLC, LUNG CANCER, Vol: 60, Pages: S8-S8, ISSN: 0169-5002
Lim E, Harris G, Patel A, et al., 2008, Preoperative versus postoperative chemotherapy for patients undergoing resection for lung cancer. Systematic review and indirect comparison meta-analysis of randomised trials, LUNG CANCER, Vol: 60, Pages: S19-S19, ISSN: 0169-5002
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