Publications
302 results found
Lim E, Maratos E, Barker A, et al., 2007, Is surgical access or procedure performed the principal determinant of outcome for surgery to prevent recurrent pneumothoraces?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A127-A128, ISSN: 0040-6376
Lim E, Belcher E, Yap YK, et al., 2007, Is surgery contraindicated for patients with small cell lung cancer and clinical N2 disease?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A41-A41, ISSN: 0040-6376
Sathianandan S, Belcher E, Letafat S, et al., 2007, Prognostic implications of improved CT detection of pulmonary metastases in patients undergoing pulmonary metastasectomy, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A132-A133, ISSN: 0040-6376
Lim EKS, Loke YK, Thompson AM, 2007, Medicine & surgery, ISBN: 9780443072604
This is a stunning new hybrid textbook that has evolved as a direct response to the increasing integration of the two disciplines of medicine and ...
Ali ZA, Callaghan CJ, Lim E, et al., 2007, Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair - A randomized controlled trial, CIRCULATION, Vol: 116, Pages: I98-I105, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 352
Lim E, Goldstraw P, 2007, Surgical sealants for air leaks after pulmonary surgery, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 32, Pages: 552-553, ISSN: 1010-7940
- Author Web Link
- Cite
- Citations: 2
Migliore M, Choong CK, Lim E, et al., 2007, A surgeon's case volume of oesophagectomy for cancer strongly influences the operative mortality rate, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 32, Pages: 375-379, ISSN: 1010-7940
- Author Web Link
- Cite
- Citations: 48
Barker A, Maratos EC, Edmonds L, et al., 2007, Recurrence rates of video-assisted thoracoscopic versus open surgery in the prevention of recurrent pneumothoraces: a systematic review of randomised and non-randomised trials, LANCET, Vol: 370, Pages: 329-335, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 109
Lim E, Dusmet M, Gotdstraw P, 2007, Surgery as primary treatment for small cell lung cancer: time to re-evaluate, LUNG CANCER, Vol: 57, Pages: S13-S13, ISSN: 0169-5002
Lim E, Goldstraw P, 2007, Surgery as primary treatment for limited disease small cell lung cancer: Time to re-evaluate, Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Lim E, 2007, Interpreting MADCAP: parallelism not divergence, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 31, Pages: 1151-1152, ISSN: 1010-7940
- Author Web Link
- Cite
- Citations: 1
Ali AA, Lim E, Thanikachalam M, et al., 2007, Cardiac arrest in the organ donor does not negatively influence recipient survival after heart transplantation, 20th Annual Meeting of the European-Association-for-Cardio-Thoracic-Surgery/14th Annual Meeting of the European-Society-of-Thoracic-Surgeons, Publisher: OXFORD UNIV PRESS INC, Pages: 929-933, ISSN: 1010-7940
- Author Web Link
- Cite
- Citations: 57
Ali AA, Lim E, Thanikachalam M, et al., 2007, Cardiac arrest in the organ donor does not negatively influence recipient survival after heart transplantation., Eur J Cardiothorac Surg, Vol: 31, Pages: 929-933, ISSN: 1010-7940
OBJECTIVE: Cardiac arrest in the organ donor raises concerns about the possibility of ischemic cardiac damage. We evaluated the outcome of heart transplantation in patients receiving an organ from donors who had suffered a period of cardiac arrest. METHODS: Demographics, operative details and outcome data were obtained retrospectively. Actuarial survival was reported using Kaplan-Meier analysis and compared with the log rank test. Cox proportional hazards regression was used to model risk adjusted survival. RESULTS: Between 1 January 1991 and 1 November 2004 38 patients were transplanted with hearts from multiorgan donors who were resuscitated after a cardiac arrest. The mean (standard deviation) duration of cardiac arrest was 15 (8)min. The interval between donor cardiac arrest and organ excision was 69 (5)h. The 30-day mortality was 2.6% (1/38). In the same interim 566 patients underwent cardiac transplantation with hearts from organ donors without a cardiac arrest. Median time to follow up was 61 months (IQR 15-166). One and 5-year survival comparing the arrest and non-arrest groups was 94.2% versus 83.6% and 79.8% versus 74.5%, respectively, p=0.35. Donor cardiac arrest was not an adverse predictor of mortality on multivariate analysis, the adjusted odds ratio was 0.86 (95% CI 0.60-1.25, p=0.42). CONCLUSIONS: With careful case selection, there was no evidence that survival after cardiac transplantation was worse following a period of cardiac arrest in the organ donor. A history of cardiac arrest in the organ donor should not exclude an organ from being considered for transplantation.
Rizvi SMH, Goodwill J, Lim E, et al., 2007, The incidence of neuroendorine cell hyperplasia (NEH) in pulmonary neuroendocrine tumours and non-small cell carcinomas, 96th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, Publisher: NATURE PUBLISHING GROUP, Pages: 329A-329A, ISSN: 0893-3952
Lim E, Carballo S, Cornelissen J, et al., 2007, Dose-related efficacy of aspirin after coronary surgery in patients with Pl<SUP>A2</SUP> polymorphism (NCT00262275), ANNALS OF THORACIC SURGERY, Vol: 83, Pages: 134-139, ISSN: 0003-4975
- Author Web Link
- Cite
- Citations: 17
Lim E, 2007, Invited commentary., Ann Thorac Surg, Vol: 83, Pages: 202-203
Lim E, Drain A, Davies W, et al., 2006, A systematic review of randomized trials comparing revascularization rate and graft patency of off-pump and conventional coronary surgery, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 132, Pages: 1409-1413, ISSN: 0022-5223
- Author Web Link
- Cite
- Citations: 65
Carr-White GS, Lim E, Koh TW, et al., 2006, Regional ventricular dynamics during acute coronary occlusion: A comparison of invasive with non-invasive echocardiographic markers to detect and quantify myocardial ischaemia - observations made during off-pump coronary surgery, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 113, Pages: 376-384, ISSN: 0167-5273
Chambers JC, Lim E, Elliott P, et al., 2006, The age and gender related patterns of insulin resistance in UK Indian Asians and Northern Europeans: The London Life Sciences Population (LOLIPOP) Study, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 902-903, ISSN: 0009-7322
Lim TK, Lim E, Jain P, et al., 2006, Investigation of the relationship between type 2 diabetes and left ventricular function in men and women aged 35-75 years, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 895-895, ISSN: 0009-7322
Duncan AM, Lim E, Clague J, et al., 2006, Comparison of segmental and global markers of dyssynchrony in predicting clinical response to cardiac resynchronization, EUROPEAN HEART JOURNAL, Vol: 27, Pages: 2426-2432, ISSN: 0195-668X
- Author Web Link
- Cite
- Citations: 50
Lim E, Tsui S, 2006, Impact of the European Working Time Directive on exposure to operative cardiac surgical training, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 30, Pages: 574-577, ISSN: 1010-7940
- Author Web Link
- Cite
- Citations: 36
Tansley P, Al-Mulhim F, Lim E, et al., 2006, A prospective, randomized, controlled trial of the effectiveness of BioGlue in treating alveolar air leaks, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 132, Pages: 105-112, ISSN: 0022-5223
- Author Web Link
- Cite
- Citations: 63
Lim E, Cornelissen J, Routledge T, et al., 2006, Biological efficacy of low versus medium dose aspirin after coronary surgery: results from a randomized trial [NCT00262275], BMC Medicine, Vol: 4, Pages: 1-6, ISSN: 1741-7015
BackgroundThe beneficial effect of aspirin after coronary surgery is established; however, a recent study reported the inability of low doses (100 mg) to inhibit postoperative platelet function. We conducted a double-blind randomised trial to establish the efficacy of low dose aspirin and to compare it against medium dose aspirin.MethodsPatients undergoing coronary surgery were invited to participate and consenting patients were randomised to 100 mg or 325 mg of aspirin daily for 5 days. Our primary outcome was the difference in platelet aggregation (day 5 – baseline) using 1 μg/ml of collagen. Secondary outcomes were differences in EC50 of collagen, ADP and epinephrine (assessed using the technique of Born).ResultsFrom September 2002 to April 2004, 72 patients were randomised; 3 patients discontinued, leaving 35 and 34 in the low and medium dose aspirin arms respectively. The mean aggregation (using 1.1 μg/ml of collagen) was reduced in both the medium and low dose aspirin arms by 37% and 36% respectively. The baseline adjusted difference (low – medium) was 6% (95% CI -3 to 14; p = 0.19). The directions of the results for the differences in EC50 (low – medium) were consistent for collagen, ADP and epinephrine at -0.07 (-0.53 to 0.40), -0.08 (-0.28 to 0.11) and -4.41 (-10.56 to 1.72) respectively, but none were statistically significant.ConclusionContrary to recent findings, low dose aspirin is effective and medium dose aspirin did not prove superior for inhibiting platelet aggregation after coronary surgery.
Lim E, Ali A, Cartwright N, et al., 2006, Effect and duration of lung volume reduction surgery: Mid-term results of the Brompton trial, THORACIC AND CARDIOVASCULAR SURGEON, Vol: 54, Pages: 188-192, ISSN: 0171-6425
- Author Web Link
- Cite
- Citations: 9
Cornelissen J, Kirtland S, Lim E, et al., 2006, Biological efficacy of low against medium dose aspirin regimen after coronary surgery: analysis of platelet function., Thromb Haemost, Vol: 95, Pages: 476-482, ISSN: 0340-6245
The failure of aspirin to inhibit platelet function has been documented in patients undergoing coronary artery bypass graft (CABG) surgery, but the causes of "aspirin-resistance" remain uncertain. The aim of this study was to investigate the efficacy of aspirin in patients undergoing CABG surgery receiving either 100 mg or 325 mg of oral aspirin for 5-days. Platelet function was tested the day before surgery and on day +1 and day +5, and evaluated by changes in collagen-induced thromboxane-A2 (TxA2) release and platelet aggregation following stimulation with collagen, ADP and epinephrine. In all patients, baseline platelet aggregation was significantly inhibited by pre-incubation with in vitro aspirin (150 micromol/l), with a mean reduction in TxA2-release of >or=95.5% (82.3,99.1). After 5-days of oral aspirin, platelet aggregation was significantly inhibited, and was not further inhibited by in vitro aspirin. Oral aspirin was also associated with a >or=99.5% (97.8, 99.7) reduction in TxA2-release, and with the reversal of the second-phase of ADP-induced aggregation which is TxA2-dependent. In addition a single-dose of 325 mg aspirin on the first post-operative morning may have a greater inhibitory effect on collagen-induced aggregation than 100 mg aspirin. Western blot analysis provided no evidence for the presence of COX-2 in platelets, while the up-regulation of p38-MAPK following platelet-stimulation and surgery was seen. The inhibition of COX-2 (NS398) or p38-MAPK (SB203580) activity did not affect platelet aggregation and TxA2-release on day +5. In summary, there was no evidence for inherent or acquired aspirin-resistance in this surgical population, or for the involvement of either COX-2 or p38-MAPK.
Lim E, Choy LL, Flaks L, et al., 2006, Detected troponin elevation is associated with high early mortality after lung resection for cancer, JOURNAL OF CARDIOTHORACIC SURGERY, Vol: 1, ISSN: 1749-8090
- Author Web Link
- Open Access Link
- Cite
- Citations: 18
Lim E, Goldstraw P, 2005, Insertion of a chest tube to drain pneumothorax, Anaesthesia and Intensive Care Medicine, Vol: 6, Pages: 416-417, ISSN: 1472-0299
Intercostal chest tube drainage with an underwater seal is a simple and effective method to eliminate air in the pleural space. The patient is then positioned lying, shoulder elevated and undressed to the waist with the arm abducted at 90°. The fourth intercostal space just anterior to the midaxillary line is usually chosen. The surgical field is prepared with antiseptic solution, and lidocaine is injected to create a transverse wheal to demarcate the length and position of the skin incision. The tip of the scalpel blade is used to make an incision large enough to admit the index finger comfortably. Blunt dissection is undertaken using a Roberts clamp. Once the deep fascia is reached, the intercostals space becomes distinctive. Further lidocaine is used to create a field block by injecting multiple intercostal nerves. After leaving adequate time for the intercostal block to work, the Roberts clamp is then used with gentle but firm pressure, spreading the intercostals muscles apart. When the Roberts clamp enters the pleural cavity, a gush of air is normally audible. The jaw of the Roberts is opened to dilate the puncture site, and then followed by the index finger to dilate a tract into the pleural space. Once satisfied that there is no adherent lung tissue to the chest wall, a 28 F drain is introduced into the pleural space without a trocar. Once the drain is sited, it is attached to an underwater seal, and the drain is then secured with a silk suture. © 2005 Elsevier Ltd. All rights reserved.
Lim E, Goldstraw P, 2005, Chest drain for pneumothorax, Foundation Years, Vol: 1, Pages: 40-42, ISSN: 1744-1889
Kelion A, Davies G, Flint J, et al., 2005, Setting up a myocardial perfusion scintigraphy service: Clinical and business aspects, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 26, Pages: 847-858, ISSN: 0143-3636
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.