Imperial College London

Dr Ernesto Yagüe

Faculty of MedicineDepartment of Surgery & Cancer

Non-Clinical Lecturer in Cancer Cell Biology



+44 (0)20 7594 2802ernesto.yague Website




Cancer Research Centre, room 135ICTEM buildingHammersmith Campus





Drug Resistance Group

My research interests centre on molecular mechanisms of resistance to cancer chemotherapy and more in particular on the role of micro RNAs on breast cancer.


MRes in Cancer Biology Stream Director

I also supervise several PhD and post-graduate students and collaborate in the Faculty of Medicine undergraduate teaching and tutoring.


I obtained the degree of Doctor in Biology by the Complutense University (Madrid). After post-doctoral positions at the Pasteur Institute (Paris), King's College (London) and in the biotech industry, I joined Prof. Christopher Higgins' laboratory at the Medical Research Council as a senior research scientist working on drug resistance. I moved to Imperial College in October 2007.



Kumar U, Hu Y, Masrour N, et al., 2021, MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells, Biochemical Pharmacology, Vol:192, ISSN:0006-2952, Pages:1-15

Kumar U, Ardasheva A, Mahmud Z, et al., 2021, FOXA1 is a determinant of drug resistance in breast cancer cells, Breast Cancer Research and Treatment, Vol:186, ISSN:0167-6806, Pages:317-326

Masood M, Grimm S, El-Bahrawy M, et al., 2020, TMEFF2: A transmembrane proteoglycan with multifaceted actions in cancer and disease, Cancers, Vol:12, ISSN:2072-6694, Pages:1-25

Aimjongjun S, Mahmud Z, Jiramongkol Y, et al., 2019, Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation, Bmc Cancer, Vol:19, ISSN:1471-2407

Li D, Wang L, Yagüe E, et al., 2019, Studies of proteasome inhibition and apoptosis induction in triple‐negative breast cancer cells by novel amino acid–polypyridine–copper complex, Applied Organometallic Chemistry, Vol:33, ISSN:0268-2605

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