Imperial College London

Dr Ernesto Yagüe

Faculty of MedicineDepartment of Surgery & Cancer

Non-Clinical Lecturer in Cancer Cell Biology



+44 (0)20 7594 2802ernesto.yague Website




Cancer Research Centre, room 135ICTEM buildingHammersmith Campus





Drug Resistance Group

My research interests centre on molecular mechanisms of resistance to cancer chemotherapy and more in particular on the role of micro RNAs on breast cancer.


MRes in Cancer Biology Stream Director

I also supervise several PhD and post-graduate students and collaborate in the Faculty of Medicine undergraduate teaching and tutoring.


I obtained the degree of Doctor in Biology by the Complutense University (Madrid). After post-doctoral positions at the Pasteur Institute (Paris), King's College (London) and in the biotech industry, I joined Prof. Christopher Higgins' laboratory at the Medical Research Council as a senior research scientist working on drug resistance. I moved to Imperial College in October 2007.



Kumar U, Castellanos-Uribe M, May ST, et al., 2023, Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer, Gene, Vol:850, ISSN:0378-1119

Zhang M, Xiao F, Li Y, et al., 2022, The miR-106b-25 cluster mediates drug resistance in myeloid leukaemias by inactivating multiple apoptotic genes, International Journal of Hematology, ISSN:0925-5710, Pages:1-15

Yagüe E, Sun H, Hu Y, 2022, East Wind, West Wind: Toward the modernization of traditional Chinese medicine., Frontiers in Neuroscience, Vol:16, ISSN:1662-453X, Pages:1-17

Li X, Guo K, Zhang R, et al., 2022, Exploration of the mechanism of salvianolic acid for injection against ischemic stroke: a research based on computational prediction and experimental validation, Frontiers in Pharmacology, Vol:13, ISSN:1663-9812, Pages:1-13

Kumar U, Hu Y, Masrour N, et al., 2021, MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells, Biochemical Pharmacology, Vol:192, ISSN:0006-2952, Pages:1-15

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