Imperial College London
Alternate

Dr Ernesto Yagüe

Faculty of Medicine, Department of Surgery & Cancer

Non-Clinical Lecturer in Cancer Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 2802ernesto.yague Website

 
 
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Location

 

Cancer Research Centre, room 135ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Theodorou:2019:10.1039/C8NR09409H,
author = {Theodorou, I and Ruenraroengsak, P and Carter, D and Jiang, Q and Yague, E and Aboagye, E and Coombes, RC and Porter, AE and Ryan, M and Xie, F},
doi = {10.1039/C8NR09409H},
journal = {Nanoscale},
pages = {2079--2088},
title = {Towards multiplexed near-infrared cellular imaging using gold nanostar arrays with tunable fluorescence enhancement},
url = {http://dx.doi.org/10.1039/C8NR09409H},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sensitive detection of disease biomarkers expressed by human cells is critical to the development of novel diagnostic and therapeutic methods. Here we report that plasmonic arrays based on gold nanostar (AuNS) monolayers enable up to 19-fold fluorescence enhancement for cellular imaging in the near-infrared (NIR) biological window, allowing the application of low quantum yield fluorophores for sensitive cellular imaging. The high fluorescence enhancement together with low autofluorescence interference in this wavelength range enable higher signal-to-noise ratio compared to other diagnostic modalities. Using AuNSs of different geometries and therefore controllable electric field enhancement, cellular imaging with tunable enhancement factors is achieved, which may be useful for the development of multicolour and multiplexed platforms for a panel of biomarkers, allowing to distinguish different subcell populations at the single cell level. Finally, the uptake of AuNSs within HeLa cells and their high biocompatibility, pave the way for novel high-performance in vitro and in vivo diagnostic platforms.
AU  - Theodorou,I
AU  - Ruenraroengsak,P
AU  - Carter,D
AU  - Jiang,Q
AU  - Yague,E
AU  - Aboagye,E
AU  - Coombes,RC
AU  - Porter,AE
AU  - Ryan,M
AU  - Xie,F
DO  - 10.1039/C8NR09409H
EP  - 2088
PY  - 2019///
SN  - 2040-3364
SP  - 2079
TI  - Towards multiplexed near-infrared cellular imaging using gold nanostar arrays with tunable fluorescence enhancement
T2  - Nanoscale
UR  - http://dx.doi.org/10.1039/C8NR09409H
UR  - http://hdl.handle.net/10044/1/66967
VL  - 11
ER  -
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