Imperial College London
Alternate

Dr Ernesto Yagüe

Faculty of Medicine, Department of Surgery & Cancer

Non-Clinical Lecturer in Cancer Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 2802ernesto.yague Website

 
 
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Location

 

Cancer Research Centre, room 135ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhao:2017:10.3892/ol.2017.5832,
author = {Zhao, X and Zhao, J and Yao, Q and Zhang, G and Shen, H and Yague, E and Hu, Y},
doi = {10.3892/ol.2017.5832},
journal = {Oncology Letters},
pages = {3071--3079},
title = {Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer},
url = {http://dx.doi.org/10.3892/ol.2017.5832},
volume = {13},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common  complementary  and  alternative  types  of  medicine currently used in the treatment of patients with breast cancer.  Ruanjian  Sanjie  (RJSJ)  decoction,  is  composed  of  four herbs, including Ban xia (Pinellia ternata), Xia ku cao (Prunella vulgaris), Shan ci gu (Cremastra appendiculata) and  Hai  zao  (Sargassum  pallidum),  and  has  traditionally  been used for softening hard lumps and resolving hard tissue masses. However, the active compounds and mechanisms of action of RJSJ remain unknown. The present study demonstrated the antitumor activity of RJSJ against Ehrlich ascites carcinoma in Swiss albino mice and breast cancer xenografts in nude mice. Notably, RJSJ does not induce body weight loss, immune function toxicity or myelosuppression in mice, indicating that it is safe and well tolerated. In addition, RJSJ shows potent cytotoxicity against breast cancer cells in  vitro by the suppression of the antiapoptotic proteins Bcell lymphoma 2 and survivin, leading to the activation of caspase3/7 and caspase9, and the apoptotic cascade. These findings provide a clear rationale to explore the therapeutic strategy of using RJSJ alone or in combination with chemotherapeutic agents for breast cancer patients and the characterization of its active principles.
AU  - Zhao,X
AU  - Zhao,J
AU  - Yao,Q
AU  - Zhang,G
AU  - Shen,H
AU  - Yague,E
AU  - Hu,Y
DO  - 10.3892/ol.2017.5832
EP  - 3079
PY  - 2017///
SN  - 1792-1082
SP  - 3071
TI  - Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer
T2  - Oncology Letters
UR  - http://dx.doi.org/10.3892/ol.2017.5832
UR  - http://hdl.handle.net/10044/1/44798
VL  - 13
ER  -
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