Imperial College London
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Dr Francesco A. Aprile

Faculty of Natural Sciences, Department of Chemistry

Lecturer in Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5545f.aprile Website

 
 
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Location

 

110FMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ikenoue:2021:10.3389/fnins.2021.623097,
author = {Ikenoue, T and Aprile, FA and Sormanni, P and Vendruscolo, M},
doi = {10.3389/fnins.2021.623097},
journal = {Frontiers in Neuroscience},
pages = {1--9},
title = {Rationally designed bicyclic peptides prevent the conversion of A beta 42 assemblies into fibrillar structures},
url = {http://dx.doi.org/10.3389/fnins.2021.623097},
volume = {15},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is great interest in drug discovery programs targeted at the aggregation of the 42-residue form of the amyloid β peptide (Aβ42), since this molecular process is closely associated with Alzheimer’s disease. The use of bicyclic peptides may offer novel opportunities for the effective modification of Aβ42 aggregation and the inhibition of its cytotoxicity, as these compounds combine the molecular recognition ability of antibodies with a relatively small size of about 2 kD. Here, to pursue this approach, we rationally designed a panel of six bicyclic peptides targeting various epitopes along the sequence of Aβ42 to scan its most amyloidogenic region (residues 13–42). Our kinetic analysis and structural studies revealed that at sub-stoichiometric concentrations the designed bicyclic peptides induce a delay in the condensation of Aβ42 and the subsequent transition to a fibrillar state, while at higher concentrations they inhibit such transition. We thus suggest that designed bicyclic peptides can be employed to inhibit amyloid formation by redirecting the aggregation process toward amorphous assemblies.
AU  - Ikenoue,T
AU  - Aprile,FA
AU  - Sormanni,P
AU  - Vendruscolo,M
DO  - 10.3389/fnins.2021.623097
EP  - 9
PY  - 2021///
SN  - 1662-453X
SP  - 1
TI  - Rationally designed bicyclic peptides prevent the conversion of A beta 42 assemblies into fibrillar structures
T2  - Frontiers in Neuroscience
UR  - http://dx.doi.org/10.3389/fnins.2021.623097
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000627356600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fnins.2021.623097/full
UR  - http://hdl.handle.net/10044/1/92312
VL  - 15
ER  -
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