Imperial College London
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Dr Francesco A. Aprile

Faculty of Natural Sciences, Department of Chemistry

Lecturer in Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5545f.aprile Website

 
 
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Location

 

110FMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jin:2021:10.3390/ijms22084128,
author = {Jin, Y and Vadukul, D and Gialama, D and Ge, Y and Thrush, R and White, J and Aprile, F},
doi = {10.3390/ijms22084128},
journal = {International Journal of Molecular Sciences},
title = {The diagnostic potential of amyloidogenic proteins},
url = {http://dx.doi.org/10.3390/ijms22084128},
volume = {22},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Neurodegenerative disorders are a highly prevalent class of diseases, whose pathological mechanisms start before the appearance of any clear symptoms. This fact has prompted scientists to search for biomarkers that could aid early treatment. These currently incurable pathologies share the presence of aberrant aggregates called amyloids in the nervous system, which are composed of specific proteins. In this review, we discuss how these proteins, their conformations and modifications could be exploited as biomarkers for diagnostic purposes. We focus on proteins that are associated with the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and frontotemporal dementia. We also describe current challenges in detection, the most recent techniques with diagnostic potentials and possible future developments in diagnosis.
AU  - Jin,Y
AU  - Vadukul,D
AU  - Gialama,D
AU  - Ge,Y
AU  - Thrush,R
AU  - White,J
AU  - Aprile,F
DO  - 10.3390/ijms22084128
PY  - 2021///
SN  - 1422-0067
TI  - The diagnostic potential of amyloidogenic proteins
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms22084128
UR  - http://hdl.handle.net/10044/1/89557
VL  - 22
ER  -
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