Imperial College London

Fernando Avila Rencoret, M.D.

Faculty of MedicineDepartment of Surgery & Cancer

Research Postgraduate
 
 
 
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Contact

 

f.avila-rencoret13 Website CV

 
 
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Location

 

B415BBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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14 results found

Avila-Rencoret F, Mylonas G, Elson D, 2023, Robotic large-area optical biopsy imaging for automated detection of gastrointestinal cancers tested in tissue phantoms and ex vivo porcine bowel, Translational Biophotonics, Vol: 5, ISSN: 2627-1850

Gastrointestinal endoscopy is a subjective procedure that frequently requires tissue samples for diagnosis. Contact optical biopsy (OB) techniques have the aim of providing direct diagnosis of endoscopic areas without excising tissue samples but lack the wide-area coverage required for locating and resecting lesions. This article presents a large-area robotically deployed OB imaging platform for endoscopic detection of colorectal cancer as an add-on for conventional endoscopes. In vitro, in silicon colon phantoms, the platform achieves an optical resolution of 0.5 line pairs per millimeter, while resolving simulated cancer lesions down to 0.75 mm diameter across large-area images (55-103 cm2). Large-area OB images were generated in an ex vivo porcine colon. The platform allows centimeter-sized large-area OB imaging in vitro and ex vivo with submillimeter resolution, including automatic data segmentation of simulated cancer areas. The ability for robotic actuation and spectrum collection is also shown for ex vivo animal colon. If successful, this technology could widen access to user-independent high-quality endoscopy and early detection of gastrointestinal cancers.

Journal article

Gkouzionis I, Avila-Rencoret F, Murphy J, Peters C, Elson Det al., 2021, Real-time optical tracking of a diffuse reflectance spectroscopy probe for gastrointestinal tissue analysis, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, Publisher: SPIE

Conference paper

Leiloglou M, Gkouzionis I, Avila-Rencoret FB, Chalau V, Kedrzycki M, Darzi A, Leff DR, Elson DSet al., 2020, Snapshot hyperspectral system for breast conserving surgery guidance

There is an unmet need for accurate tumour localization in vivo during breast conserving surgery. Herein a novel snapshot hyperspectral system is presented for accurately detecting the intrinsic fluorescence signal in real-time fluorescence guided surgery.

Conference paper

Waldock WJ, Avila-Rencoret FB, Tincknell LG, Murphy J, Elson DS, Peters CJet al., 2018, Augmented intraoperative surgical vision for the assessment of gastrointestinal cancer resection margins, 21st Annual Meeting of the Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS), Publisher: Wiley, Pages: 15-16, ISSN: 1365-2168

Conference paper

Avila Rencoret FB, Mylonas G, Elson D, 2018, Robotic wide-field optical biopsy endoscopy, OSA Biophotonics Congress 2018, Publisher: OSA publishing

This paper describes a novel robotic framework for wide-field optical biopsy endoscopy, characterizes in vitro its spatial and spectral resolution, real time hyperspectral tissue classification, and demonstrates its feasibility on fresh porcine cadaveric colon.

Conference paper

Avila Rencoret FB, Mylonas GP, Elson D, 2018, Robotic Wide-Field Optical Biopsy Imaging For Flexible Endoscopy, 26th International Congress of the European Association for Endoscopic Surgery (EAES)

Conference paper

Avila Rencoret FB, Elson D, Mylonas G, 2016, A Robotic Hyperspectral Scanning Framework for Endoscopy, CRAS - Workshop on Computer/Robot Assisted Surgery

Gastrointestinal (GI) endoscopy is the gold-standard procedure for detection and treatment of dysplastic lesions and early stage GI cancers. Despite its proven effectiveness, its sensitivity remains suboptimal due to the subjective nature of the examination, which is substantially reliant on human-operator skills. For bowel cancer, colonoscopy can miss up to 22% of dysplastic lesions, with even higher miss rates for small (<5 mm diameter) and flat lesions. We propose a robotic hyperspectral (HS) scanning framework that aims to improve the sensitivity of GI endoscopy by automated scanning and real-time classification of wide tissue areas based on their HS features. A “hot-spot” map is generated to highlight dysplastic or cancerous lesions for further scrutiny or concurrent resection. The device works as an add-on accessory to any conventional endoscope, and to our knowledge, is the first of its kind. This paper focuses on characterising its optical resolution on rigid and deformable colon phantoms. We report for the first time 2D and 3D wide-area reconstruction of endoscopic HS data with sub-millimetre optical resolution. The current setup, compatible with the anatomical dimensions of the colon, could allow the identification of flat and small pre-cancerous lesions that are currently missed. The proposed framework will lay the foundations towards the next generation of augmented reality endoscopy while increasing its sensitivity and specificity.

Conference paper

Avila Rencoret FB, Elson DS, Mylonas G, 2015, Probe Deployment Device

Patent

Avila-Rencoret FB, Elson DS, Mylonas G, 2015, Towards a robotic-assisted cartography of the colon: a proof of concept, Publisher: IEEE COMPUTER SOC, Pages: 1757-1763

Conference paper

Avila-Rencoret F, Mylonas G, Elson DS, 2014, A Novel Endoscopic Scanning-Probe Device for Rapid Screening of Gastrointestinal Dysplasia, Publisher: The Bioengineering Society

Conference paper

Bermudez C, Toyoda Y, Avila F, Mulukutla S, Marroquin O, Teuteberg J, Kormos Ret al., 2010, Use of Extracorporeal Membrane Oxygenation (ECMO) in Patients with Chronic Cardiomyopathy: A Word of Caution, 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Publisher: ELSEVIER SCIENCE INC, Pages: S179-S180, ISSN: 1053-2498

Conference paper

Bermudez C, Toyoda Y, Avila F, Mulukutla S, Marroquin O, Teuteberg J, Kormos Ret al., 2010, 552: Use of Extracorporeal Membrane Oxygenation (ECMO) in Patients with Chronic Cardiomyopathy: A Word of Caution, The Journal of Heart and Lung Transplantation, Vol: 29, Pages: S179-S180, ISSN: 1053-2498

Journal article

Bermudez C, Girnita A, Avila F, Zeeva A, Crespo M, Pilewski J, Speziali G, Johnson B, Zaldonis D, Toyoda Yet al., 2009, Clinical Experience with the Use of Virtual Crossmatch in Adult Lung Transplantation, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 28, Pages: S136-S136, ISSN: 1053-2498

Journal article

Bermudez C, Wei L, Avila F, Toyoda Y, Siegenthaler M, Spadaccio C, Mulukutla S, Schindler J, Refaat M, Kormos Ret al., 2009, Use of Extracorporeal Membrane Oxygenation in Advanced Cardiogenic Shock Complicating an Acute Myocardial Infarction, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 28, Pages: S273-S273, ISSN: 1053-2498

Journal article

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