Imperial College London
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Professor Fernando Bresme

Faculty of Natural Sciences, Department of Chemistry

Professor of Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 5886f.bresme Website

 
 
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Assistant

 

Miss Ravinder Dhaliwal +44 (0)20 7594 5717

 
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Location

 

207CMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gonzalez:2020:10.1021/acs.jpcb.0c04059,
author = {Gonzalez, MA and Bresme, F},
doi = {10.1021/acs.jpcb.0c04059},
journal = {The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter},
pages = {5156--5162},
title = {Membrane-ion interactions modify the lipid flip-flop dynamics of biological membranes: a molecular dynamics study},
url = {http://dx.doi.org/10.1021/acs.jpcb.0c04059},
volume = {124},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The asymmetric distribution of lipids in the cell membrane is maintained by protein transporters, and in the absence of proteins, by spontaneous flip-flop of lipids that involve the formation of transient pores in the membrane. The composition of the cell membranes influences the metabolism of the cell by modulating the function of transmembrane proteins, and flip-flop processes are therefore of key importance. Membranes are in direct contact with aqueous solutions, containing ions of different compositions that interact with the lipid head groups or cross the cell membrane through transmembrane channels. The impact of the ions on the lipid flip-flop rates is, however, an outstanding question. Here, we show that the flip-flop rate slows down significantly with the increasing valence of the cation, from minutes for monovalent cations (Na+, K+) to hours for divalent (Mg2+, Ca2+) or days for trivalent cations (Yb3+).
AU  - Gonzalez,MA
AU  - Bresme,F
DO  - 10.1021/acs.jpcb.0c04059
EP  - 5162
PY  - 2020///
SN  - 1520-5207
SP  - 5156
TI  - Membrane-ion interactions modify the lipid flip-flop dynamics of biological membranes: a molecular dynamics study
T2  - The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter
UR  - http://dx.doi.org/10.1021/acs.jpcb.0c04059
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32520561
UR  - https://pubs.acs.org/doi/10.1021/acs.jpcb.0c04059
UR  - http://hdl.handle.net/10044/1/79935
VL  - 124
ER  -
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