Imperial College London
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DrFrancescaCeroni

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

f.ceroni

 
 
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Location

 

510AACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Di:2021:10.1021/acschembio.0c00771,
author = {Di, Blasi R and Blyuss, O and Timms, JF and Conole, D and Ceroni, F and Whitwell, HJ},
doi = {10.1021/acschembio.0c00771},
journal = {ACS Chemical Biology},
pages = {238--250},
title = {Non-histone protein methylation: biological significance and bioengineering potential},
url = {http://dx.doi.org/10.1021/acschembio.0c00771},
volume = {16},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Protein methylation is a key post-translational modification whose effects on gene expression have been intensively studied over the last two decades. Recently, renewed interest in non-histone protein methylation has gained momentum for its role in regulating important cellular processes and the activity of many proteins, including transcription factors, enzymes, and structural complexes. The extensive and dynamic role that protein methylation plays within the cell also highlights its potential for bioengineering applications. Indeed, while synthetic histone protein methylation has been extensively used to engineer gene expression, engineering of non-histone protein methylation has not been fully explored yet. Here, we report the latest findings, highlighting how non-histone protein methylation is fundamental for certain cellular functions and is implicated in disease, and review recent efforts in the engineering of protein methylation.
AU  - Di,Blasi R
AU  - Blyuss,O
AU  - Timms,JF
AU  - Conole,D
AU  - Ceroni,F
AU  - Whitwell,HJ
DO  - 10.1021/acschembio.0c00771
EP  - 250
PY  - 2021///
SN  - 1554-8929
SP  - 238
TI  - Non-histone protein methylation: biological significance and bioengineering potential
T2  - ACS Chemical Biology
UR  - http://dx.doi.org/10.1021/acschembio.0c00771
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33411495
UR  - https://pubs.acs.org/doi/10.1021/acschembio.0c00771
UR  - http://hdl.handle.net/10044/1/85791
VL  - 16
ER  -
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