Imperial College London
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DrFrancescaCeroni

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

f.ceroni

 
 
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Location

 

510AACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Ceroni:2009:10.1142/9789814295291_0043,
author = {Ceroni, F and Furini, S and Cavalcanti, S},
doi = {10.1142/9789814295291_0043},
pages = {409--420},
publisher = {World Scientific Publishing Company},
title = {A computational model of gene expression in an inducible synthetic circuit},
url = {http://dx.doi.org/10.1142/9789814295291_0043},
year = {2009}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Synthetic biology aims to the rational design of gene circuits with predictable behaviours. Great efforts have been done so far to introduce in the field mathematical models that could facilitate the design of synthetic networks. Here we present a mathematical model of a synthetic gene-circuit with a negative feedback. The closed loop configuration allows the control of transcription by an inducer molecule (IPTG). Escherichia coli bacterial cells were transformed and expression of a fluorescent reporter (GFP) was measured for different inducer levels. Computer model simulations well reproduced the experimental induction data, using a single fitting parameter. Independent genetic components were used to assemble the synthetic circuit. The mathematical model here presented could be useful to predict how changes in these genetic components affect the behaviour of the synthetic circuit.
AU  - Ceroni,F
AU  - Furini,S
AU  - Cavalcanti,S
DO  - 10.1142/9789814295291_0043
EP  - 420
PB  - World Scientific Publishing Company
PY  - 2009///
SN  - 2335-6936
SP  - 409
TI  - A computational model of gene expression in an inducible synthetic circuit
UR  - http://dx.doi.org/10.1142/9789814295291_0043
UR  - http://hdl.handle.net/10044/1/31353
ER  -
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