Imperial College London
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DrFrancescaCeroni

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

f.ceroni

 
 
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Location

 

510AACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ceroni:2015:10.1038/NMETH.3339,
author = {Ceroni, F and Algar, R and Stan, G-B and Ellis, T},
doi = {10.1038/NMETH.3339},
journal = {Nature Methods},
pages = {415--418},
title = {Quantifying cellular capacity identifies gene expression designs with reduced burden},
url = {http://dx.doi.org/10.1038/NMETH.3339},
volume = {12},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Heterologous gene expression can be a significant burden forcells. Here we describe an in vivo monitor that tracks changesin the capacity of Escherichia coli in real time and can be usedto assay the burden imposed by synthetic constructs and theirparts. We identify construct designs with reduced burden thatpredictably outperformed less efficient designs, despite havingequivalent output.
AU  - Ceroni,F
AU  - Algar,R
AU  - Stan,G-B
AU  - Ellis,T
DO  - 10.1038/NMETH.3339
EP  - 418
PY  - 2015///
SN  - 1548-7105
SP  - 415
TI  - Quantifying cellular capacity identifies gene expression designs with reduced burden
T2  - Nature Methods
UR  - http://dx.doi.org/10.1038/NMETH.3339
UR  - http://hdl.handle.net/10044/1/31367
VL  - 12
ER  -
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