Imperial College London

Dr Francesca Chaloner

Faculty of MedicineDepartment of Brain Sciences

Research Associate - UK Dementia Research Institute



f.chaloner CV




5.D.27Burlington DanesHammersmith Campus





I joined the Barnes Lab (UK DRI) in October 2023. The Barnes lab investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility, with a focus on homeostatic neural-circuit plasticity processes. My current focus is dissecting the underlying physiological differences which contribute to variable learning across ageing. To investigate this, I use a number of techniques, longitudinal 2-Photon in vivo imaging, in vivo mesoscopic calcium imaging, in vivo electrophysiology, immunofluorescence labelling, behavioural testing and electrical stimulation interventions.

In 2018, I was awarded a prestigious MRC 1 3 PhD programme position at the Centre for Neurodevelopmental Disorders (CNDD), King’s College London. During my PhD with Samuel Cooke (KCL), I investigated the role of inhibitory interneurons in visual cortical plasticity and behavioural habituation using in vivo electrophysiology, optogenetics, chemogenetics and ex vivo electrophysiology. In addition, I used a combination of MATLAB and Python based tools for stimulus generation and data analysis.



Chaloner FA, Cooke SF, 2022, Multiple Mechanistically Distinct Timescales of Neocortical Plasticity Occur During Habituation, Frontiers in Cellular Neuroscience, Vol:16

Montgomery DP, Hayden DJ, Chaloner FA, et al., 2022, Stimulus-Selective Response Plasticity in Primary Visual Cortex: Progress and Puzzles, Frontiers in Neural Circuits, Vol:15

Kim T, Chaloner FA, Cooke SF, et al., 2020, Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex, Frontiers in Cellular Neuroscience, Vol:13

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