Imperial College London
Alternate

ProfessorFanChung

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 7954f.chung Website

 
 
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Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
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Location

 

227BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

1584 results found

CHUNG KF, BARNES PJ, 1992, ROLE OF INFLAMMATORY MEDIATORS IN ASTHMA, BRITISH MEDICAL BULLETIN, Vol: 48, Pages: 135-148, ISSN: 0007-1420

Journal article

ELWOOD W, BARNES PJ, CHUNG KF, 1992, AIRWAY HYPERRESPONSIVENESS IS ASSOCIATED WITH INFLAMMATORY CELL INFILTRATION IN ALLERGIC BROWN-NORWAY RATS, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol: 99, Pages: 91-97, ISSN: 1018-2438

Journal article

CHUNG KF, 1992, CORTICOSTEROID-THERAPY IN ASTHMA - ARE METABOLIC CONSIDERATIONS IMPORTANT, JOURNAL OF ASTHMA, Vol: 29, Pages: 299-301, ISSN: 0277-0903

Journal article

LOTVALL JO, ELWOOD W, TOKUYAMA K, BARNES PJ, CHUNG KFet al., 1991, DIFFERENTIAL-EFFECTS OF PHOSPHORAMIDON ON NEUROKININ-A-INDUCED AND SUBSTANCE-P-INDUCED AIR-FLOW OBSTRUCTION AND AIRWAY MICROVASCULAR LEAKAGE IN GUINEA-PIG, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 104, Pages: 945-949, ISSN: 0007-1188

Journal article

CHUNG KF, BARNES PJ, 1991, ROLE FOR PLATELET-ACTIVATING-FACTOR IN ASTHMA, 3RD INTERNATIONAL CONF ON PLATELET-ACTIVATING FACTOR AND STRUCTURALLY RELATED ALKYLI ETHER LIPIDS, Publisher: AMER OIL CHEMISTS SOC, Pages: 1277-1279, ISSN: 0024-4201

Conference paper

ELWOOD W, LOTVALL JO, BARNES PJ, CHUNG KFet al., 1991, CHARACTERIZATION OF ALLERGEN-INDUCED BRONCHIAL HYPERRESPONSIVENESS AND AIRWAY INFLAMMATION IN ACTIVELY SENSITIZED BROWN-NORWAY RATS, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 88, Pages: 951-960, ISSN: 0091-6749

Journal article

TOKUYAMA K, LOTVALL JO, MORIKAWA A, BARNES PJ, CHUNG KFet al., 1991, ROLE OF THROMBOXANE-A2 IN AIRWAY MICROVASCULAR LEAKAGE INDUCED BY INHALED PLATELET-ACTIVATING-FACTOR, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 71, Pages: 1729-1734, ISSN: 8750-7587

Journal article

SNASHALL PD, CHUNG KF, 1991, AIRWAY-OBSTRUCTION AND BRONCHIAL HYPERRESPONSIVENESS IN LEFT-VENTRICULAR FAILURE AND MITRAL-STENOSIS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 144, Pages: 945-956, ISSN: 0003-0805

Journal article

SHOCK A, RABE KF, DENT G, CHAMBERS RC, GRAY AJ, CHUNG KF, BARNES PJ, LAURENT CJet al., 1991, EOSINOPHILS ADHERE TO AND STIMULATE REPLICATION OF LUNG FIBROBLASTS INVITRO, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 86, Pages: 185-190, ISSN: 0009-9104

Journal article

LOTVALL JO, TOKUYAMA K, BARNES PJ, CHUNG KFet al., 1991, BRADYKININ-INDUCED AIRWAY MICROVASCULAR LEAKAGE IS POTENTIATED BY CAPTOPRIL AND PHOSPHORAMIDON, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 200, Pages: 211-217, ISSN: 0014-2999

Journal article

HAYES JP, RIDGE SM, GRIFFITH S, BARNES PJ, CHUNG KFet al., 1991, INHIBITION OF CUTANEOUS AND PLATELET RESPONSES TO PLATELET-ACTIVATING-FACTOR BY ORAL WEB 2086 IN MAN, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 88, Pages: 83-88, ISSN: 0091-6749

Journal article

ELWOOD W, LOTVALL JO, BARNES PJ, CHUNG KFet al., 1991, LOOP DIURETICS INHIBIT CHOLINERGIC AND NONCHOLINERGIC NERVES IN GUINEA-PIG AIRWAYS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 143, Pages: 1340-1344, ISSN: 0003-0805

Journal article

WIGGINS J, STRICKLAND B, CHUNG KF, 1991, DETECTION OF BRONCHIECTASIS BY HIGH-RESOLUTION COMPUTED-TOMOGRAPHY IN THE YELLOW NAIL SYNDROME, CLINICAL RADIOLOGY, Vol: 43, Pages: 377-379, ISSN: 0009-9260

Journal article

TOKUYAMA K, LOTVALL JO, BARNES PJ, CHUNG KFet al., 1991, MECHANISM OF AIRWAY NARROWING CAUSED BY INHALED PLATELET-ACTIVATING-FACTOR - ROLE OF AIRWAY MICROVASCULAR LEAKAGE, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 143, Pages: 1345-1349, ISSN: 0003-0805

Journal article

LOTVALL JO, TOKUYAMA K, LOFDAHL CG, ULLMAN A, BARNES PJ, CHUNG KFet al., 1991, PEPTIDASE MODULATION OF NONCHOLINERGIC VAGAL BRONCHOCONSTRICTION AND AIRWAY MICROVASCULAR LEAKAGE, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 70, Pages: 2730-2735, ISSN: 8750-7587

Journal article

OCONNOR BJ, CHUNG KF, CHENWORSDELL YM, FULLER RW, BARNES PJet al., 1991, EFFECT OF INHALED FUROSEMIDE AND BUMETANIDE ON ADENOSINE 5'-MONOPHOSPHATE- AND SODIUM METABISULFITE-INDUCED BRONCHOCONSTRICTION IN ASTHMATIC SUBJECTS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 143, Pages: 1329-1333, ISSN: 0003-0805

Journal article

BIENSTOCK D, CHUNG F, FREDMAN ML, SCHAFFER AA, SHOR PW, SURI Set al., 1991, A NOTE ON FINDING A STRICT SADDLEPOINT, AMERICAN MATHEMATICAL MONTHLY, Vol: 98, Pages: 418-419, ISSN: 0002-9890

Journal article

HUI KP, LOTVALL J, CHUNG KF, BARNES PJet al., 1991, ATTENUATION OF INHALED ALLERGEN-INDUCED AIRWAY MICROVASCULAR LEAKAGE AND AIR-FLOW OBSTRUCTION IN GUINEA-PIGS BY A 5-LIPOXYGENASE INHIBITOR (A-63162), AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 143, Pages: 1015-1019, ISSN: 0003-0805

Journal article

Hui KP, Lötvall J, Chung KF, Barnes PJet al., 1991, Attenuation of inhaled allergen-induced airway microvascular leakage and airflow obstruction in guinea pigs by a 5-lipoxygenase inhibitor (A-63162)., Am Rev Respir Dis, Vol: 143, Pages: 1015-1019, ISSN: 0003-0805

Leukotrienes, products of the 5-lipoxygenase pathway in the metabolism of arachidonic acid, are potent mediators of airway microvascular leakage and smooth muscle contraction in guinea pigs. We studied the effect of a specific 5-lipoxygenase inhibitor, A-63162, on airway microvascular leakage and airflow obstruction following inhaled ovalbumin in actively sensitized guinea pigs. Airway microvascular leakage was assessed by extravasation of Evans blue dye into airway tissues. Inhaled ovalbumin caused increased lung resistance (RL) with decreased dynamic compliance (CL) and increased extravasation of Evans blue dye at all airway levels. A-63162 reduced the changes in RL and CL at 1.0 mumol/kg (p less than 0.05) but not at lower doses of 0.1 and 0.3 mumol/kg. A-63162 reduced Evans blue dye extravasation in airway tissues at all three doses, however, being most effective in the distal airways (p less than 0.01), and these reductions were greater than those in RL and CL. A 5-lipoxygenase inhibitor thus reduced airway microvascular leakage to a greater extent than airflow obstruction, suggesting that leukotrienes have a larger contribution to changes in airway microvascular permeability than smooth muscle contraction following inhaled allergen challenge in actively sensitized guinea pigs in vivo.

Journal article

TEBOUL B, TRILLER H, CHUNG F, BERNARD N, ZHANG ZG, WALL JR, SALVI Met al., 1991, MUSCLE AND SPECIES REACTIVITY OF MOUSE MONOCLONAL-ANTIBODIES TO HUMAN EYE MUSCLE MEMBRANE-ANTIGENS, CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol: 59, Pages: 104-116, ISSN: 0090-1229

Journal article

LOTVALL JO, ELWOOD W, TOKUYAMA K, BARNES PJ, CHUNG KFet al., 1991, PLASMA EXUDATION INTO AIRWAYS INDUCED BY INHALED PLATELET-ACTIVATING-FACTOR - EFFECT OF PEPTIDASE INHIBITION, CLINICAL SCIENCE, Vol: 80, Pages: 241-247, ISSN: 0143-5221

Journal article

CHUNG KF, PODGORSKI MR, GOULDING NJ, GODOLPHIN JL, SHARLAND PR, OCONNOR B, FLOWER RJ, BARNES PJet al., 1991, CIRCULATING AUTOANTIBODIES TO RECOMBINANT LIPOCORTIN-1 IN ASTHMA, RESPIRATORY MEDICINE, Vol: 85, Pages: 121-124, ISSN: 0954-6111

Journal article

LOFDAHL CG, CHUNG KF, 1991, LONG-ACTING BETA-2-ADRENOCEPTOR AGONISTS - A NEW PERSPECTIVE IN THE TREATMENT OF ASTHMA, EUROPEAN RESPIRATORY JOURNAL, Vol: 4, Pages: 218-226, ISSN: 0903-1936

Journal article

LOTVALL JO, HUI KP, LOFDAHL CG, BARNES PJ, CHUNG KFet al., 1991, CAPSAICIN PRETREATMENT DOES NOT INHIBIT ALLERGEN-INDUCED AIRWAY MICROVASCULAR LEAKAGE IN GUINEA-PIG, ALLERGY, Vol: 46, Pages: 105-108, ISSN: 0105-4538

Journal article

TOKUYAMA K, LOTVALL JO, LOFDAHL CG, BARNES PJ, CHUNG KFet al., 1991, INHALED FORMOTEROL INHIBITS HISTAMINE-INDUCED AIR-FLOW OBSTRUCTION AND AIRWAY MICROVASCULAR LEAKAGE, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 193, Pages: 35-39, ISSN: 0014-2999

Journal article

Lotvall JO, Tokuyama K, Lofdahl CG, Ullman A, Barnes PJ, Chung KFet al., 1991, Erratum: Peptidase modulation of noncholinergic vagal bronchoconstriction and airway microvascular leakage (Journal of Applied Physiology (June 1991) 70 (2730-2735)), Journal of Applied Physiology, Vol: 71, ISSN: 0161-7567

Journal article

RABE KF, CHUNG KF, 1991, THE CHALLENGE OF LONG-ACTING BETA-ADRENOCEPTOR AGONISTS, RESPIRATORY MEDICINE, Vol: 85, Pages: 5-9, ISSN: 0954-6111

Journal article

LOTVALL JO, SKOOGH BE, LEMEN RJ, ELWOOD W, BARNES PJ, CHUNG KFet al., 1990, BRONCHOCONSTRICTION INDUCED BY INHALED SODIUM METABISULFITE IN THE GUINEA-PIG - EFFECT OF CAPSAICIN PRETREATMENT AND OF NEUTRAL ENDOPEPTIDASE INHIBITION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 142, Pages: 1390-1395, ISSN: 0003-0805

Journal article

Lötvall JO, Skoogh BE, Lemen RJ, Elwood W, Barnes PJ, Chung KFet al., 1990, Bronchoconstriction induced by inhaled sodium metabisulfite in the guinea pig. Effect of capsaicin pretreatment and of neutral endopeptidase inhibition., Am Rev Respir Dis, Vol: 142, Pages: 1390-1395, ISSN: 0003-0805

Sodium metabisulfite (MBS), a commonly used preservative, induces bronchoconstriction in asthmatics, probably through the release of sulfur dioxide (SO2). The mechanisms involved in MBS- and SO2-induced bronchoconstriction are not yet certain. We aerosolized MBS or acid control solution (pH, 2.7) to anesthetized, tracheostomized guinea pigs pretreated intravenously with propranolol (1 mg/kg). MBS was given at increasing doubling concentrations (0.01, 0.02, 0.04, and 0.08 M) every 5 min. Steep concentration-response curves were observed, and most animals responded at 0.02 or 0.04 M. Tachyphylaxis was seen at high concentrations and during a subsequent MBS challenge 15 min later. For pharmacologic studies, we stopped the challenge when lung resistance (RL) had increased by at least 350%; a second challenge was found to be reproducible. MBS response was measured as the concentration needed to increase RL by 350% (PC350). Atropine (1 mg/kg given intravenously) did not affect PC350 or the peak RL response. Inhibition of neutral endopeptidase by inhaled phosphoramidon (7.5 nmol) administered before the repeated challenge did not alter PC350 value to MBS or peak RL responses (phosphoramidon, 201 +/- 49% of first peak; vehicle, 164 +/- 35%). In addition, the increase in RL was not prolonged in the phosphoramidon-treated group. Animals treated subcutaneously with capsaicin (50 mg/kg) 1 wk before the experiment, so as to deplete neuropeptides from airway sensory nerves, had PC350 values similar to those of the control animals. Our data demonstrate that inhaled MBS causes bronchoconstriction in guinea pigs by mechanisms that are due neither to a cholinergic reflex nor to the release of tachykinins from airway sensory nerves.

Journal article

BARNES PJ, BOSCHETTO P, ROGERS DF, BELVISI M, ROBERTS N, CHUNG KF, EVANS TWet al., 1990, EFFECTS OF TREATMENT ON AIRWAY MICROVASCULAR LEAKAGE, EUROPEAN RESPIRATORY JOURNAL, Vol: 3, Pages: S663-S671, ISSN: 0903-1936

Journal article

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