Imperial College London
Alternate

ProfessorFanChung

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 7954f.chung Website

 
 
//

Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
//

Location

 

227BGuy Scadding BuildingRoyal Brompton Campus

//

Summary

 

Publications

Publication Type
Year
to

1584 results found

Wang C-H, Lo C-Y, Huang H-Y, Wang T-Y, Weng C-M, Chen C-J, Huang Y-C, Chung F-T, Lin C-W, Chung KF, Kuo H-Pet al., 2022, Oxygen Desaturation Is Associated With Fibrocyte Activation<i> via</i> Epidermal Growth Factor Receptor/Hypoxia- Inducible Factor-1a Axis in Chronic Obstructive Pulmonary Disease, FRONTIERS IN IMMUNOLOGY, Vol: 13, ISSN: 1664-3224

Journal article

Huang K, Chung KF, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Xu G, Wu S, Wang Y, Gu X, Wang R, Shi Z, Xu Y, Ye X, Song Y, Wang Q, Zhou Y, Li W, Ding L, Wan C, Yao W, Guo Y, Xiao F, Lu Y, Peng X, Xiao D, Bu X, Zhang H, Zhang X, An L, Zhang S, Cao Z, Zhan Q, Yang Y, Liang L, Wang W, Dai H, Cao B, He J, Wang Cet al., 2022, Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China, FRONTIERS IN MEDICINE, Vol: 9

Journal article

Deng SJ, Wang J, Liu L, Zhang X, Gibson PG, Chen ZH, Birring SS, Xie M, Lai KF, Qin L, Liu D, Vertigan AE, Song W-J, McGarvey L, Luo FM, Chung KF, Li WM, Wang Get al., 2022, Chronic cough in asthma is associated with increased airway inflammation, more comorbidities, and worse clinical outcomes, ALLERGY AND ASTHMA PROCEEDINGS, Vol: 43, Pages: 209-219, ISSN: 1088-5412

Journal article

Masfufa IW, Chung KF, Adcock I, 2022, Clinical characteristic of severe asthma patients with JAK-STAT pathway activation, IFCC WorldLab Congress, Publisher: ELSEVIER, Pages: S32-S32, ISSN: 0009-8981

Conference paper

Fricker M, Qin L, Sanchez-Ovando S, Simpson JL, Baines KJ, Riveros C, Scott HA, Wood LG, Wark PAB, Kermani NZ, Chung KF, Gibson PGet al., 2022, An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype, ALLERGY, Vol: 77, Pages: 1204-1215, ISSN: 0105-4538

Journal article

Kang YR, Oh J-Y, Lee J-H, Small PM, Chung KF, Song W-Jet al., 2022, Long-COVID severe refractory cough: discussion of a case with 6-week longitudinal cough characterization, ASIA PACIFIC ALLERGY, Vol: 12, ISSN: 2233-8276

Journal article

Chen R, Michaeloudes C, Liang Y, Bhavsar PK, Chung KF, Ip MSM, Mak JCWet al., 2022, ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 149, Pages: 1445-+, ISSN: 0091-6749

Journal article

Lee K-Y, Wu S-M, Kou H-Y, Chen K-Y, Chuang H-C, Feng P-H, Chung KF, Ito K, Chen T-T, Sun W-L, Liu W-T, Tseng C-H, Ho S-Cet al., 2022, Association of air pollution exposure with exercise-induced oxygen desaturation in COPD, RESPIRATORY RESEARCH, Vol: 23

Journal article

Liu W-T, Wang Y-H, Chang L-T, Wu C-D, Wu D, Tsai C-Y, Lo C-C, Lo K, Chung KF, Chang T-Y, Chuang K-J, Lee Y-L, Chuang H-Cet al., 2022, The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, ISSN: 0944-1344

Journal article

Tiotiu A, Badi Y, Kermani NZ, Sanak M, Kolmert J, Wheelock CE, Hansbro PM, Dahlen S-E, Sterk PJ, Djukanovic R, Guo Y, Mumby S, Adcock IM, Chung KFet al., 2022, Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 205, Pages: 397-+, ISSN: 1073-449X

Journal article

Hsiao T-C, Cheng P-C, Chi KH, Wang H-Y, Pan S-Y, Kao C, Lee Y-L, Kuo H-P, Chung KF, Chuang H-Cet al., 2022, Interactions of chemical components in ambient PM<sub>2.5 </sub>with influenza viruses, JOURNAL OF HAZARDOUS MATERIALS, Vol: 423, ISSN: 0304-3894

Journal article

Mikus MS, Kolmert J, Andersson L, Ostling J, Knowles RG, Gomez C, Ericsson M, Thorngren J-O, Khoonsari PE, Dahlen B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horvath I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Nizankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandstrom T, Shaw DE, Siafakas NM, Uhlen M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlen S-E, James Aet al., 2022, Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation, European Respiratory Journal, Vol: 59, Pages: 1-17, ISSN: 0903-1936

Rationale Asthma phenotyping requires novel biomarker discovery.Objectives To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs).Methods An antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by relation to objective OCS measures in U-BIOPRED.Results In U-BIOPRED, 110 proteins were significantly different, mostly elevated, in SA compared to MMA and HCs. 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-β and glutathione S-transferase). OCS treatment decreased most proteins, yet differences between SA and MMA remained following correction for OCS use. Consensus clustering of U-BIOPRED protein data yielded six clusters associated with asthma control, quality of life, blood neutrophils, high-sensitivity C-reactive protein and body mass index, but not Type-2 inflammatory biomarkers. The mast cell specific enzyme carboxypeptidase A3 was one major contributor to cluster differentiation.Conclusions The plasma proteomic panel revealed previously unexplored yet potentially useful Type-2-independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.

Journal article

Zhang Q, Fu X, Wang C, Shen H, Zhu L, Shi G, Qiu Z, Wen Z, Gu W, Luo W, Zhao L, Chen Y, Lim S, Xiao C, Kang J, Zhang Y, Huang M, Xu J, Huang K, Li Q, Zhang X, Zhao J, Liu X, Sun S, Tang H, He B, Cai S, Chen P, Wei C, Wang G, Chen P, Xie L, Lin J, Tang Y, Han Z, Chung KF, Zhong Net al., 2022, Severe eosinophilic asthma in Chinese C-BIOPRED asthma cohort, CLINICAL AND TRANSLATIONAL MEDICINE, Vol: 12, ISSN: 2001-1326

Journal article

Lai K, Zhan W, Wu F, Zhang Y, Lin L, Li W, Yi F, Jiang Z, Dai Y, Li S, Lin J, Yuan Y, Jiang Y, Qiu C, Zhao L, Chen M, Qiu Z, Li H, Chen R, Luo W, Xie J, Guo C, Jiang M, Yang X, Shi G, Sun D, Chen R, Chung KF, Shen H, Zhong Net al., 2022, Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort, FRONTIERS IN MEDICINE, Vol: 8

Journal article

Huang H-Y, Chung F-T, Lin C-Y, Lo C-Y, Huang Y-T, Huang Y-C, Lai Y-T, Gan S-T, Ko P-C, Lin H-C, Chung KF, Wang C-Het al., 2022, Influence of Comorbidities and Airway Clearance on Mortality and Outcomes of Patients With Severe Bronchiectasis Exacerbations in Taiwan, FRONTIERS IN MEDICINE, Vol: 8

Journal article

Chang J-H, Lee Y-L, Laiman V, Han C-L, Jheng Y-T, Lee K-Y, Yeh C-T, Kuo H-P, Chung KF, Heriyanto DS, Hsiao T-C, Wu S-M, Ho S-C, Chuang K-J, Chuang H-Cet al., 2022, Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema, CHEMICO-BIOLOGICAL INTERACTIONS, Vol: 351, ISSN: 0009-2797

Journal article

Badi Y, Pavel AB, Pavlidis S, Riley J, Bates S, Zounemat Kermani N, Knowles R, Kolmert J, Wheelock C, Worsley S, Uddin M, Alving K, Bakke P, Behndig A, Caruso M, Chanez P, Fleming L, Fowler S, Frey U, Howarth P, Horvath I, Krug N, Maitland van der Zee A, Montuschi P, Roberts G, Sanak M, Shaw D, Singer F, Sterk P, Djukanovic R, Dahlen S-E, Guo Y, Chung KF, Guttman-Yassky E, Adcock IM, on behalf of theU-BIOPRED Study Groupet al., 2022, Mapping atopic dermatitis and anti–IL-22 response signatures to type 2–low severe neutrophilic asthma, Journal of Allergy and Clinical Immunology, Vol: 149, Pages: 89-101, ISSN: 0091-6749

Background:Transcriptomic changes in patients who respond clinically to biological therapies may identify responses in other tissues or diseases.Objective:We sought to determine whether a disease signature identified in atopic dermatitis (AD) is seen in adults with severe asthma and whether a transcriptomic signature for patients with AD who respond clinically to anti–IL-22 (fezakinumab [FZ]) is enriched in severe asthma.Methods:An AD disease signature was obtained from analysis of differentially expressed genes between AD lesional and nonlesional skin biopsies. Differentially expressed genes from lesional skin from therapeutic superresponders before and after 12 weeks of FZ treatment defined the FZ-response signature. Gene set variation analysis was used to produce enrichment scores of AD and FZ-response signatures in the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes asthma cohort.Results:The AD disease signature (112 upregulated genes) encompassing inflammatory, T-cell, TH2, and TH17/TH22 pathways was enriched in the blood and sputum of patients with asthma with increasing severity. Patients with asthma with sputum neutrophilia and mixed granulocyte phenotypes were the most enriched (P < .05). The FZ-response signature (296 downregulated genes) was enriched in asthmatic blood (P < .05) and particularly in neutrophilic and mixed granulocytic sputum (P < .05). These data were confirmed in sputum of the Airway Disease Endotyping for Personalized Therapeutics cohort. IL-22 mRNA across tissues did not correlate with FZ-response enrichment scores, but this response signature correlated with TH22/IL-22 pathways.Conclusions:The FZ-response signature in AD identifies severe neutrophilic asthmatic patients as potential responders to FZ therapy. This approach will help identify patients for future asthma clinical trials of drugs used successfully in other chronic diseases.

Journal article

Abdel-Aziz MI, Vijverberg SJH, Neerincx AH, Brinkman P, Wagener AH, Riley JH, Sousa AR, Bates S, Wagers SS, De Meulder B, Auffray C, Wheelock AM, Bansal AT, Caruso M, Chanez P, Uddin M, Corfield J, Horvath I, Krug N, Musial J, Sun K, Shaw DE, Sandstrom T, Montuschi P, Fowler SJ, Lutter R, Djukanovic R, Howarth P, Skipp P, Sanak M, Adcock IM, Chung KF, Sterk PJ, Kraneveld AD, der Zee AHM-Vet al., 2022, A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes, EUROPEAN RESPIRATORY JOURNAL, Vol: 59, ISSN: 0903-1936

Journal article

Bai K-J, Tung NT, Hsiao T-C, Chen T-L, Chung KF, Ho S-C, Tsai C-Y, Chen J-K, Lee C-N, Lee K-Y, Chang C-C, Chen T-T, Feng P-H, Chen K-Y, Su C-L, Thao HNX, Dung HB, Thuy TPC, Lee Y-L, Chuang H-Cet al., 2022, Associations between lung-deposited dose of particulate matter and culture-positive pulmonary tuberculosis pleurisy, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, Vol: 29, Pages: 6140-6150, ISSN: 0944-1344

Journal article

Liu Q, Zhang H, Han B, Jiang H, Chung KF, Li Fet al., 2021, Interstitial lung abnormalities: What do we know and how do we manage?, EXPERT REVIEW OF RESPIRATORY MEDICINE, Vol: 15, Pages: 1551-1561, ISSN: 1747-6348

Journal article

Zhang Q, Luo W, Zhan W, Xie J, Wang H, Chung KF, Lai Ket al., 2021, Non-asthmatic eosinophilic bronchitis is characterized by proximal airway eosinophilic inflammation as compared with classic asthma and cough variant asthma, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 51, Pages: 1637-1640, ISSN: 0954-7894

Journal article

Reinke S, Naz S, Kermani N, Chaleckis R, Kolmert J, Strom M, Wheelock A, Djukanovic R, Chung F, Adcock I, Dahlen S-E, Wheelock Cet al., 2021, The carnitine pathway is dysregulated in asthma in an oral corticosteroid-independent mechanism, 2021 ERS International Congress, Publisher: European Respiratory Society, ISSN: 0903-1936

Background: Asthma is a heterogeneous disease with poorly defined phenotypes.Aim: To identify metabolic dysregulations associated with asthma severity and evaluate the effects of asthma medication upon observed metabotypes.Methods: Baseline urine was collected from healthy controls (HC, n=108), mild-to-moderate asthmatics (MMA, n=87) and severe asthmatics (SA, n=418) from the U-BIOPRED cohort. 12-18 month longitudinal samples were collected from the SA cohort (n=305). Metabolomic data were acquired using mass spectrometry and analyzed using multivariate statistics. Gene set variation analysis (GSVA) was performed on bronchial brushing transcriptomic data.Results: 90 metabolites were identified with 40 altered in asthma (FDR<0.1). Multivariate modeling showed that HC and MMA differed significantly from all SA (p=1.4 ×10-14) and that oral corticosteroid (OCS)-treated asthmatics differed significantly from non-treated (p=9.52 ×10-4). Longitudinal samples were metabolically stable relative to baseline. OCS affected the levels of 25% of the metabolites, while theophylline affected 12%, and omalizumab had a minimal effect. Carnitine levels decreased in SA in an OCS-independent fashion. Carnitine is involved in long-chain fatty acid metabolism in mitochondria, which decreased along with levels of the carnitine transporter SLC22A5 in association with asthma severity in bronchial brushings, with differences strengthened by Th2 high/low stratification.Conclusions: SA have a dysregulated urinary metabolic profile that is strongly confounded by OCS treatment. Altered carnitine metabolism is independent of OCS and associated with mitochondrial dysfunction, presenting a potential target for intervention.

Conference paper

Lin C-W, Huang H-Y, Chung F-T, Lo C-Y, Huang Y-C, Wang T-W, Yang L-Y, Pan Y-B, Chung KF, Wang C-Het al., 2021, Emphysema-Predominant COPD Had a Greater 5-Year Mortality and a Worse Annual Decline in Lung Function Than Airway Obstruction-Predominant COPD or Asthma at Initial Same Degree of Airflow Obstruction, MEDICINA-LITHUANIA, Vol: 57, ISSN: 1010-660X

Journal article

Porsbjerg C, Maitland-van der Zee AH, Brusselle G, Canonica GW, Agusti A, Faner R, Vogelmeier CF, Nawijn M, van den Berge M, Rusconi F, Pilette C, Ramiconi V, Coleman C, Chaudhuri R, Chung KF, Wedzicha J, Saglani S, Van der Schee MP, Heaney L, Bourdin A, Roberts G, Djukanovic R, Kuna P, Kupczyk M, Axmann J, Staudinger H, Clarke GW, Dahlen SE, Brightling Cet al., 2021, 3TR: a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD, EUROPEAN RESPIRATORY JOURNAL, Vol: 58, ISSN: 0903-1936

Journal article

Chung KF, 2021, Increasing utility of FeNO as a biomarker of type-2 inflammation in severe asthma, LANCET RESPIRATORY MEDICINE, Vol: 9, Pages: 1083-1084, ISSN: 2213-2600

Journal article

Chen X-Y, Chen Y-Y, Lin W, Chen C-H, Wen Y-C, Hsiao T-C, Chou H-C, Chung KF, Chuang H-Cet al., 2021, Therapeutic Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Recovering From Murine Pulmonary Emphysema Under Cigarette Smoke Exposure, FRONTIERS IN MEDICINE, Vol: 8

Journal article

Nguyen TT, Ho S-C, Lu Y-H, Chen T-T, Lee K-Y, Chen K-Y, Wu C-D, Chung KF, Kuo H-P, Huynh NXT, Hoang BD, Tran PCT, Wu S-M, Kou H-Y, Lee Y-L, Chuang H-Cet al., 2021, Association Between Air Pollution and Lung Lobar Emphysema in COPD, FRONTIERS IN MEDICINE, Vol: 8

Journal article

Kuks P, Kole T, Kraft M, Siddiqui S, Fabbri L, Rabe K, Nicolini G, Papi A, Brightling C, Singh D, Zounemat-Kermani N, Chung F, Adcock I, Kerstjens H, Van Den Berge Met al., 2021, Neutrophilic inflammation in sputum does not define a clinical distinct asthma phenotype in ATLANTIS, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Tiotiu A, Badi Y, Abubakr-Waziri H, Versi A, Wiegman C, Hansbro PM, Mumby S, Dahlen S-E, Sterk P, Djukanovic R, Adkock IM, Chung KFet al., 2021, Sputum transcriptomic analysis of air pollutant signatures: link to asthma severity and phenotype, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Perry MM, Tildy B, Papi A, Casolari P, Caramori G, Rempel KL, Halayko AJ, Adcock I, Chung KFet al., 2021, The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide (Retraction of Vol 19, art no 85, 2018), Respiratory Research, Vol: 22, Pages: 1-1, ISSN: 1465-9921

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00155593&limit=30&person=true&page=5&respub-action=search.html