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@article{van:2020:10.1183/13993003.01163-2019,
author = {van, Bragt JJMH and Adcock, IM and Bel, EHD and Braunstahl, G-J and Ten, Brinke A and Busby, J and Canonica, GW and Cao, H and Chung, KF and Csoma, Z and Dahlen, B and Davin, E and Hansen, S and Heffler, E and Horvath, I and Korn, S and Kots, M and Kuna, P and Kwon, N and Louis, R and Plaza, V and Porsbjerg, C and Ramos-Barbon, D and Richards, LB and Skrgat, S and Sont, JK and Vijverberg, SJH and Weersink, EJ and Yasinska, V and Wagers, SS and Djukanovic, R and Maitland-van, der Zee AH and SHARP, CRC},
doi = {10.1183/13993003.01163-2019},
journal = {European Respiratory Journal},
title = {Characteristics and treatment regimens across ERS SHARP severe asthma registries},
url = {http://dx.doi.org/10.1183/13993003.01163-2019},
volume = {55},
year = {2020}
}

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TY  - JOUR
AB  - Little is known about the characteristics and treatments of patients with severe asthma across Europe but both are likely to vary. This is the first study in the ERS Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals. This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases. Analysis of data from 3233 patients showed many differences in characteristics and life style factors. Current smokers ranged from 0% (Poland, PL, Sweden, SE) to 9.5% (Belgium, BE), mean BMI ranged from 26.2 (Italy) to 30.6kg·m-2 (UK) and the largest difference in mean pre-bronchodilator FEV1% pred. was 20.9% (Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean ICS dose ranged from 700 to 1335µg·day-1 between those from Slovenia (SL) versus PL when starting anti-IL-5 antibody and from 772 to 1344µg·day-1 in those starting anti-IgE (SL versus Spain). Maintenance OCS use ranged from 21.0% (BE) to 63.0% (SE) and from 9.1% (Denmark) to 56.1% (UK) in patients starting anti-IL-5 and anti-IgE, respectively. The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current ERS/ATS guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.
AU  - van,Bragt JJMH
AU  - Adcock,IM
AU  - Bel,EHD
AU  - Braunstahl,G-J
AU  - Ten,Brinke A
AU  - Busby,J
AU  - Canonica,GW
AU  - Cao,H
AU  - Chung,KF
AU  - Csoma,Z
AU  - Dahlen,B
AU  - Davin,E
AU  - Hansen,S
AU  - Heffler,E
AU  - Horvath,I
AU  - Korn,S
AU  - Kots,M
AU  - Kuna,P
AU  - Kwon,N
AU  - Louis,R
AU  - Plaza,V
AU  - Porsbjerg,C
AU  - Ramos-Barbon,D
AU  - Richards,LB
AU  - Skrgat,S
AU  - Sont,JK
AU  - Vijverberg,SJH
AU  - Weersink,EJ
AU  - Yasinska,V
AU  - Wagers,SS
AU  - Djukanovic,R
AU  - Maitland-van,der Zee AH
AU  - SHARP,CRC
DO  - 10.1183/13993003.01163-2019
PY  - 2020///
SN  - 0903-1936
TI  - Characteristics and treatment regimens across ERS SHARP severe asthma registries
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.01163-2019
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31601713
UR  - http://hdl.handle.net/10044/1/74140
VL  - 55
ER  -

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