Imperial College London
Alternate

ProfessorFanChung

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 7954f.chung Website

 
 
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Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
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Location

 

227BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tan:2020:10.3389/fcell.2020.00099,
author = {Tan, KS and Lim, RL and Liu, J and Ong, HH and Tan, VJ and Lim, HF and Chung, KF and Adcock, IM and Chow, VT and Wang, DY},
doi = {10.3389/fcell.2020.00099},
journal = {Front Cell Dev Biol},
pages = {99--99},
title = {Respiratory viral infections in exacerbation of chronic airway inflammatory diseases: novel mechanisms and insights from the upper airway epithelium.},
url = {http://dx.doi.org/10.3389/fcell.2020.00099},
volume = {8},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory virus infection is one of the major sources of exacerbation of chronic airway inflammatory diseases. These exacerbations are associated with high morbidity and even mortality worldwide. The current understanding on viral-induced exacerbations is that viral infection increases airway inflammation which aggravates disease symptoms. Recent advances in in vitro air-liquid interface 3D cultures, organoid cultures and the use of novel human and animal challenge models have evoked new understandings as to the mechanisms of viral exacerbations. In this review, we will focus on recent novel findings that elucidate how respiratory viral infections alter the epithelial barrier in the airways, the upper airway microbial environment, epigenetic modifications including miRNA modulation, and other changes in immune responses throughout the upper and lower airways. First, we reviewed the prevalence of different respiratory viral infections in causing exacerbations in chronic airway inflammatory diseases. Subsequently we also summarized how recent models have expanded our appreciation of the mechanisms of viral-induced exacerbations. Further we highlighted the importance of the virome within the airway microbiome environment and its impact on subsequent bacterial infection. This review consolidates the understanding of viral induced exacerbation in chronic airway inflammatory diseases and indicates pathways that may be targeted for more effective management of chronic inflammatory diseases.
AU  - Tan,KS
AU  - Lim,RL
AU  - Liu,J
AU  - Ong,HH
AU  - Tan,VJ
AU  - Lim,HF
AU  - Chung,KF
AU  - Adcock,IM
AU  - Chow,VT
AU  - Wang,DY
DO  - 10.3389/fcell.2020.00099
EP  - 99
PY  - 2020///
SN  - 2296-634X
SP  - 99
TI  - Respiratory viral infections in exacerbation of chronic airway inflammatory diseases: novel mechanisms and insights from the upper airway epithelium.
T2  - Front Cell Dev Biol
UR  - http://dx.doi.org/10.3389/fcell.2020.00099
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32161756
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00099/full
UR  - http://hdl.handle.net/10044/1/77716
VL  - 8
ER  -
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