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@article{Roberts:2020:10.1016/j.jaci.2020.02.031,
author = {Roberts, G and Fontanella, S and Selby, A and Howard, R and Filippi, S and Hedlin, G and Nordlund, B and Howarth, P and Hashimoto, S and Brinkman, P and Fleming, LJ and Murray, C and Bush, A and Frey, U and Singer, F and Schoos, A-MM and van, Aalderen W and Djukanovic, R and Chung, KF and Sterk, PJ and Adnan, C and U-BIOPRED, Consortium},
doi = {10.1016/j.jaci.2020.02.031},
journal = {Journal of Allergy and Clinical Immunology},
pages = {821--830},
title = {Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma},
url = {http://dx.doi.org/10.1016/j.jaci.2020.02.031},
volume = {146},
year = {2020}
}

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TY  - JOUR
AB  - BACKGROUND: Allergic sensitization is associated with severe asthma, but assessment of sensitization is not recommended by most guidelines. OBJECTIVE: We hypothesized that patterns of IgE responses to multiple allergenic proteins differ between sensitized participants with mild/moderate and severe asthma. METHODS: IgE to 112 allergenic molecules (components, c-sIgE) was measured using multiplex array among 509 adults and 140 school-age and 131 preschool children with asthma/wheeze from the Unbiased BIOmarkers for the PREDiction of respiratory diseases outcomes cohort, of whom 595 had severe disease. We applied clustering methods to identify co-occurrence patterns of components (component clusters) and patterns of sensitization among participants (sensitization clusters). Network analysis techniques explored the connectivity structure of c-sIgE, and differential network analysis looked for differences in c-sIgE interactions between severe and mild/moderate asthma. RESULTS: Four sensitization clusters were identified, but with no difference between disease severity groups. Similarly, component clusters were not associated with asthma severity. None of the c-sIgE were identified as associates of severe asthma. The key difference between school children and adults with mild/moderate compared with those with severe asthma was in the network of connections between c-sIgE. Participants with severe asthma had higher connectivity among components, but these connections were weaker. The mild/moderate network had fewer connections, but the connections were stronger. Connectivity between components with no structural homology tended to co-occur among participants with severe asthma. Results were independent from the different sample sizes of mild/moderate and severe groups. CONCLUSIONS: The patterns of interactions between IgE to multiple allergenic proteins are predictors of asthma severity among school children and adults with allergic asthma.
AU  - Roberts,G
AU  - Fontanella,S
AU  - Selby,A
AU  - Howard,R
AU  - Filippi,S
AU  - Hedlin,G
AU  - Nordlund,B
AU  - Howarth,P
AU  - Hashimoto,S
AU  - Brinkman,P
AU  - Fleming,LJ
AU  - Murray,C
AU  - Bush,A
AU  - Frey,U
AU  - Singer,F
AU  - Schoos,A-MM
AU  - van,Aalderen W
AU  - Djukanovic,R
AU  - Chung,KF
AU  - Sterk,PJ
AU  - Adnan,C
AU  - U-BIOPRED,Consortium
DO  - 10.1016/j.jaci.2020.02.031
EP  - 830
PY  - 2020///
SN  - 0091-6749
SP  - 821
TI  - Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma
T2  - Journal of Allergy and Clinical Immunology
UR  - http://dx.doi.org/10.1016/j.jaci.2020.02.031
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32188567
UR  - https://www.sciencedirect.com/science/article/pii/S0091674920303419?via%3Dihub
UR  - http://hdl.handle.net/10044/1/81403
VL  - 146
ER  -

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