Publications

BibTex format

@article{Kolmert:2020:10.1164/rccm.201909-1869OC,
author = {Kolmert, J and Gómez, C and Balgoma, D and Sjödin, M and Bood, J and Konradsen, JR and Ericsson, M and Thörngren, J-O and James, A and Mikus, M and Sousa, AR and Riley, JH and Bates, S and Bakke, PS and Pandis, I and Caruso, M and Chanez, P and Fowler, SJ and Geiser, T and Howarth, P and Horváth, I and Krug, N and Montuschi, P and Sanak, M and Behndig, A and Shaw, DE and Knowles, RG and Holweg, CTJ and Wheelock, ÅM and Dahlén, B and Nordlund, B and Alving, K and Hedlin, G and Chung, KF and Adcock, IM and Sterk, PJ and Djukanovic, R and Dahlén, S-E and Wheelock, CE and U-BIOPRED, Study Group},
doi = {10.1164/rccm.201909-1869OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {37--53},
title = {Urinary leukotriene E4 and prostaglandin D2 metabolites increase in adult and childhood severe asthma characterized by type-2 inflammation},
url = {http://dx.doi.org/10.1164/rccm.201909-1869OC},
volume = {203},
year = {2020}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - RATIONALE: New approaches are needed to guide personalized treatment of asthma. OBJECTIVE: To test if urinary eicosanoid metabolites can direct asthma phenotyping. METHODS: Urinary metabolites of prostaglandins (PGs), cysteinyl-leukotrienes (LTs) and isoprostanes were quantified in the Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) study including 86 adults with mild-to-moderate asthma (MMA), 411 with severe asthma (SA), and 100 healthy controls (HC). Validation was performed internally in 302 SA subjects followed-up after 12-18 months, and externally in 95 adolescents with asthma. MEASUREMENT AND MAIN RESULTS: Metabolite levels in HC were unrelated to age, BMI and sex, except for the PGE2-pathway. Eicosanoid levels were generally greater in MMA relative to HC, with further elevations in SA. However, PGE2-metabolite levels were either the same or lower in male non-smoking asthmatics as in HC. Metabolite levels were unchanged in asthmatics adherent to oral corticosteroid treatment as documented by urinary prednisolone detection, whereas SA treated with omalizumab had lower levels of LTE4 and the PGD2 metabolite 2,3-dinor-11β-PGF2α. High levels of LTE4 and PGD2-metabolites were associated with lower lung-function, and increased levels of exhaled nitric oxide and eosinophil markers in blood, sputum and urine in U-BIOPRED and in adolescents with asthma. These type-2 (T2) asthma associations were reproduced in the follow-up visit of the U-BIOPRED study, and found to be as sensitive to detect T2 inflammation as the established biomarkers. CONCLUSIONS: Monitoring of urinary eicosanoids can identify T2 asthma and introduces a new non-invasive approach for molecular phenotyping of adult and adolescent asthma. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
AU  - Kolmert,J
AU  - Gómez,C
AU  - Balgoma,D
AU  - Sjödin,M
AU  - Bood,J
AU  - Konradsen,JR
AU  - Ericsson,M
AU  - Thörngren,J-O
AU  - James,A
AU  - Mikus,M
AU  - Sousa,AR
AU  - Riley,JH
AU  - Bates,S
AU  - Bakke,PS
AU  - Pandis,I
AU  - Caruso,M
AU  - Chanez,P
AU  - Fowler,SJ
AU  - Geiser,T
AU  - Howarth,P
AU  - Horváth,I
AU  - Krug,N
AU  - Montuschi,P
AU  - Sanak,M
AU  - Behndig,A
AU  - Shaw,DE
AU  - Knowles,RG
AU  - Holweg,CTJ
AU  - Wheelock,ÅM
AU  - Dahlén,B
AU  - Nordlund,B
AU  - Alving,K
AU  - Hedlin,G
AU  - Chung,KF
AU  - Adcock,IM
AU  - Sterk,PJ
AU  - Djukanovic,R
AU  - Dahlén,S-E
AU  - Wheelock,CE
AU  - U-BIOPRED,Study Group
DO  - 10.1164/rccm.201909-1869OC
EP  - 53
PY  - 2020///
SN  - 1073-449X
SP  - 37
TI  - Urinary leukotriene E4 and prostaglandin D2 metabolites increase in adult and childhood severe asthma characterized by type-2 inflammation
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.201909-1869OC
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32667261
UR  - https://www.atsjournals.org/doi/10.1164/rccm.201909-1869OC
UR  - http://hdl.handle.net/10044/1/83646
VL  - 203
ER  -

Download

ProfessorFanChung

Contact

Assistant

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)