Dr Culley is an immunologist working in the fields of respiratory inflammation and infection, and the influence of age on respiratory immunity.
Dr Culley studied Natural Sciences at Cambridge University, then moved to the London School of Hygiene and Tropical Medicine to study the immunology of trachoma, performing field work in the Gambia, West Africa. For her PhD at the University of London (LSHTM), she identified novel pattern recognition properties of C-reactive protein, and its exploitation by Leishmania parasites. She moved to Imperial College London to undertake her postdoctoral research, during which she developed her interests in respiratory immunology and inflammation. She identified novel mechanisms of immunoevasion and regulation of respiratory inflammation by helminth parasites with Prof. Tim Williams FRS and Prof Murray Selkirk. Working on respiratory viral infection, in Prof Peter Openshaw’s laboratory, she established the neonatal model of Respiratory Syncytial Virus infection, demonstrating the importance of age in the immune response to respiratory infection. As research lecturer with Prof Dan Davis, she used live cell confocal microscopy to study Natural Killer signal integration during synapse formation.
Since establishing her group, she continues to work on respiratory immunology and inflammation, particularly in the context of RSV infection, and the influence of age on respiratory immunity both in neonates and the elderly. Her research has been funded by the MRC, BMA, The Wellcome Trust, The Rosetrees Trust and Asthma UK.
Dr Culley is Course Director for the BSc in Immunity and Infection. She leads the Application of Genomics in Infectious Disease module of the MSc in Genomic Medicine. She is Committee member, School 1 lead and Tutor for The Wellcome Trust 4-Year PhD Training Programme in the Molecular & Cellular Basis of Infection. She was awarded a Certificate in Advanced Studies in Learning and Teaching in 2010 and is a Fellow of the Higher Education Academy.
Dr Culley is a member of the local AWERB committee and is academic lead for the St Mary's campus core flow cytometry facility.
She is the Treasurer, a Trustee and media spokesperson for the British Society for Immunology.
et al., 2017, Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis, Lancet Infectious Diseases, Vol:17, ISSN:1473-3099, Pages:e223-e234
et al., 2017, Protective and Harmful Immunity to RSV Infection, Annual Review of Immunology, Vol:35, ISSN:0732-0582, Pages:501-532
et al., 2014, Immunity to RSV in early-life, Frontiers in Immunology, Vol:5, ISSN:1664-3224
et al., 2014, Respiratory Syncytial Virus Infection, TLR3 Ligands, and Proinflammatory Cytokines Induce CD161 Ligand LLT1 Expression on the Respiratory Epithelium, Journal of Virology, Vol:88, ISSN:0022-538X, Pages:2366-2373
et al., 2013, Natural Killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation, Journal of Allergy and Clinical Immunology
et al., 2012, Preexposure to CpG Protects against the Delayed Effects of Neonatal Respiratory Syncytial Virus Infection, Journal of Virology, Vol:86, ISSN:0022-538X, Pages:10456-10461
et al., 2009, Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration, PLOS Biology, Vol:7, ISSN:1544-9173