Publications
297 results found
Mboma SM, Houben RMGJ, Glynn JR, et al., 2013, Control of (Multi)Drug Resistance and Tuberculosis Incidence over 23 Years in the Context of a Well-Supported Tuberculosis Programme in Rural Malawi, PLOS One, Vol: 8, ISSN: 1932-6203
Background: The rise in tuberculosis (TB) incidence following generalized HIV epidemics can overwhelm TB control programmes in resource-limited settings, sometimes accompanied by rising rates of drug resistance. This has led to claims that DOTS-based TB control has failed in such settings. However, few studies have described the effect of a sustained and well-supported DOTS programme on TB incidence and drug resistance over a long period. We present long-term trends in incidence and drug resistance in rural Malawi. Methods: Karonga District in northern Malawi has an adult HIV prevalence of ~10%. A research group, the Karonga Prevention Study, collaborates with the National Tuberculosis Programme to support core TB control activities. Bacteriological, demographic and clinical (including HIV status) information from all patients starting TB treatment in the District have been recorded since 1988. During that period isolates from each culture-positive TB patient were exported for drug sensitivity testing. Antiretroviral therapy (ART) has been widely available since 2005. Results: Incidence of new smear-positive adult TB peaked at 124/100,000/year in the mid-90s, but has since fallen to 87/100,000/year. Drug sensitivity information was available for 95% (3132/3307) of all culture-positive cases. Initial resistance to isoniazid was around 6% with no evidence of an increase. Fewer than 1% of episodes involved a multi-drug resistant strain. Discussion: In this setting with a generalised HIV epidemic and medium TB burden, a well-supported DOTS programme enhanced by routine culture and drug sensitivity testing may well have reduced TB incidence and maintained drug resistance at low levels. © 2013 Mboma et al.
Gonzalo X, Drobniewski F, 2013, Is there a place for -lactams in the treatment of multidrug-resistant/extensively drug-resistant tuberculosis? Synergy between meropenem and amoxicillin/clavulanate, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 68, Pages: 366-369, ISSN: 0305-7453
- Author Web Link
- Cite
- Citations: 54
Kontsevaya I, Ignatyeva O, Nikolayevskyy V, et al., 2013, Diagnostic Accuracy of the GenoType MTBDR<i>sl</i> Assay for Rapid Diagnosis of Extensively Drug-Resistant Tuberculosis in HIV-Coinfected Patients, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 51, Pages: 243-248, ISSN: 0095-1137
- Author Web Link
- Cite
- Citations: 19
Broda A, Jebbari H, Beaton K, et al., 2013, Comparative Drug Resistance of <i>Mycobacterium abscessus</i> and <i>M</i>. <i>chelonae</i> Isolates from Patients with and without Cystic Fibrosis in the United Kingdom, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 51, Pages: 217-223, ISSN: 0095-1137
- Author Web Link
- Cite
- Citations: 55
Wangh L, Rice J, Rice L, et al., 2013, Two single-tube multiplex assays for M(X)DR-TB and NTMs using LATE-PCR & Thermalight™ probes, Publisher: CHURCHILL LIVINGSTONE, Pages: 113-114, ISSN: 1472-9792
Basu Roy R, Rubin EJ, 2013, Mycobacterium Tuberculosis., The Prokaryotes, Editors: DeLong, Lory, Stackebrandt, Thompson, Rosenberg, Publisher: Springer:New York, NY.
Martineau AR, Coussens AK, Nikolayevskyy V, et al., 2012, ETHNIC VARIATION IN INFLAMMATORY PROFILE IN TUBERCULOSIS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A4-A4, ISSN: 0040-6376
Coussens AK, Wilkinson RJ, Hanifa Y, et al., 2012, Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 15449-15454, ISSN: 0027-8424
- Author Web Link
- Open Access Link
- Cite
- Citations: 225
Toit K, Mitchell S, Balabanova Y, et al., 2012, The Colour Test for drug susceptibility testing of <i>Mycobacterium tuberculosis</i> strains, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 16, Pages: 1113-1118, ISSN: 1027-3719
- Author Web Link
- Cite
- Citations: 18
Mironova S, Pimkina E, Kontsevaya I, et al., 2012, Performance of the GenoType® MTBDR<i>Plus</i> assay in routine settings: a multicenter study, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, Vol: 31, Pages: 1381-1387, ISSN: 0934-9723
- Author Web Link
- Cite
- Citations: 22
Drobniewski F, Nikolayevskyy V, Balabanova Y, et al., 2012, Diagnosis of tuberculosis and drug resistance: what can new tools bring us?, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 16, Pages: 860-870, ISSN: 1027-3719
- Author Web Link
- Cite
- Citations: 66
Cuevas LE, Browning R, Bossuyt P, et al., 2012, Evaluation of Tuberculosis Diagnostics in Children: 2. Methodological Issues for Conducting and Reporting Research Evaluations of Tuberculosis Diagnostics for Intrathoracic Tuberculosis in Children. Consensus From an Expert Panel<SUP>a</SUP>, JOURNAL OF INFECTIOUS DISEASES, Vol: 205, Pages: S209-S215, ISSN: 0022-1899
- Author Web Link
- Cite
- Citations: 85
Thom RE, Elmore MJ, Williams A, et al., 2012, The expression of ferritin, lactoferrin, transferrin receptor and solute carrier family 11A1 in the host response to BCG-vaccination and <i>Mycobacterium tuberculosis</i> challenge, VACCINE, Vol: 30, Pages: 3159-3168, ISSN: 0264-410X
- Author Web Link
- Cite
- Citations: 16
Balabanova Y, Radiulyte B, Davidaviciene E, et al., 2012, Risk factors for drug-resistant tuberculosis patients in Lithuania, 2002-2008, EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 1266-1269, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 12
Ignatyeva O, Kontsevaya I, Kovalyov A, et al., 2012, Detection of Resistance to Second-Line Antituberculosis Drugs by Use of the Genotype MTBDR<i>sl</i> Assay: a Multicenter Evaluation and Feasibility Study, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 50, Pages: 1593-1597, ISSN: 0095-1137
- Author Web Link
- Cite
- Citations: 43
Casali N, Nikolayevskyy V, Balabanova Y, et al., 2012, Microevolution of extensively drug-resistant tuberculosis in Russia, GENOME RESEARCH, Vol: 22, Pages: 735-745, ISSN: 1088-9051
- Author Web Link
- Open Access Link
- Cite
- Citations: 146
Seoudi N, Mitchell SL, Brown TJ, et al., 2012, Rapid molecular detection of tuberculosis and rifampicin drug resistance: retrospective analysis of a national UK molecular service over the last decade, THORAX, Vol: 67, Pages: 361-367, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 19
Thye T, Owusu-Dabo E, Vannberg FO, et al., 2012, Common variants at 11p13 are associated with susceptibility to tuberculosis, NATURE GENETICS, Vol: 44, Pages: 257-259, ISSN: 1061-4036
- Author Web Link
- Cite
- Citations: 155
Kurbatova EV, Cavanaugh JS, Shah NS, et al., 2012, Rifampicin-resistant <i>Mycobacterium tuberculosis</i>: susceptibility to isoniazid and other anti-tuberculosis drugs, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 16, Pages: 355-357, ISSN: 1027-3719
- Author Web Link
- Cite
- Citations: 28
Png E, Alisjahbana B, Sahiratmadja E, et al., 2012, A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians, BMC Medical Genetics, Vol: 13, ISSN: 1471-2350
Background: There is reason to expect strong genetic influences on the risk of developing active pulmonary tuberculosis (TB) among latently infected individuals. Many of the genome wide linkage and association studies (GWAS) to date have been conducted on African populations. In order to identify additional targets in genetically dissimilar populations, and to enhance our understanding of this disease, we performed a multi-stage GWAS in a Southeast Asian cohort from Indonesia.Methods: In stage 1, we used the Affymetrix 100 K SNP GeneChip marker set to genotype 259 Indonesian samples. After quality control filtering, 108 cases and 115 controls were analyzed for association of 95,207 SNPs. In stage 2, we attempted validation of 2,453 SNPs with promising associations from the first stage, in 1,189 individuals from the same Indonesian cohort, and finally in stage 3 we selected 251 SNPs from this stage to test TB association in an independent Caucasian cohort (n = 3,760) from Russia.Results: Our study suggests evidence of association (P = 0.0004-0.0067) for 8 independent loci (nominal significance P < 0.05), which are located within or near the following genes involved in immune signaling: JAG1, DYNLRB2, EBF1, TMEFF2, CCL17, HAUS6, PENK and TXNDC4.Conclusions: Mechanisms of immune defense suggested by some of the identified genes exhibit biological plausibility and may suggest novel pathways involved in the host containment of infection with TB. © 2012 Png et al; licensee BioMed Central Ltd.
Stone MJ, Brown TJ, Drobniewski FA, 2012, Human <i>Mycobacterium bovis</i> Infections in London and Southeast England, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 50, Pages: 164-165, ISSN: 0095-1137
- Author Web Link
- Cite
- Citations: 13
Balabanova Y, Balabanova Y, Radiulyte B, et al., 2011, Survival of drug resistant tuberculosis patients in Lithuania: Retrospective national cohort study, BMJ Open, Vol: 1, ISSN: 2044-6055
Objective: To establish risk factors influencing survival of patients with multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDRTB). Design: All MDR/XDRTB cases (n=1809) reported from 2002 to 2008 in Lithuania with a known outcome were included in the survival analysis. Results: Median survival for MDRTB and XDRTB patients was 4.1 (95% CI 3.7 to 4.4) and 2.9 (95% CI 2.2 to 3.9) years. In a multivariable analysis adjusting for other patient characteristics, the difference in survival between MDRTB and XDRTB patients was not significant (HR=1.29 (0.91 to 1.81)). Older age (HR=4.80 (3.16 to 7.29)) for 60+ vs <30 years, rural living (HR=1.20 (1.02 to 1.40)), alcohol use (HR=1.49 (1.13 to 1.96)) for alcoholic versus moderate use, unemployment (HR=1.79 (1.31 to 2.46)), lower education levels (HR=1.50 (1.08 to 2.07)) for primary level versus tertiary level, cavitary disease (HR=1.54 (1.29 to 1.83)) and being smear positive at the time of MDR/XDRTB diagnosis (HR=1.47 (1.19 to 1.82)) were associated with poorer survival. HIV positivity significantly affected survival (HR=3.44 (1.92 to 6.19)) for HIV positive versus HIV negative; HR=1.60 (1.28 to 2.01) for HIV not tested versus HIV negative). There was no difference in survival of patients who acquired MDR/XDRTB during treatment compared with patients with primary MDR/XDRTB (HR=1.01 (0.85 to 1.19)). Treatment with a second-line drug improved survival (HR=0.40 (0.34 to 0.47)). In a subgroup with genotyped TB strains, a Beijing family of strains was associated with poorer survival (HR=1.71 (1.19 to 2.47)). Conclusions: Social factors, rural living, HIV infection and Beijing strain family impact on survival. Survival of MDR/XDRTB patients is short. Rapid drug resistance identification, early administration of appropriate treatment and achieving high cure rates, expansion of HIV testing and antiretroviral treatment are necessary for optimal management of MDR/XDRTB.
Faksri K, Drobniewski F, Nikolayevskyy V, et al., 2011, Epidemiological trends and clinical comparisons of <i>Mycobacterium tuberculosis</i> lineages in Thai TB meningitis, TUBERCULOSIS, Vol: 91, Pages: 594-600, ISSN: 1472-9792
- Author Web Link
- Cite
- Citations: 22
Balabanova Y, Balabanova Y, Tchernyshev V, et al., 2011, Analysis of undiagnosed tuberculosis-related deaths identified at post-mortem among HIV-infected patients in Russia: A descriptive study, BMC Infectious Diseases, Vol: 11, ISSN: 1471-2334
Background: Tuberculosis remains a serious public health threat and economic burden in Russia with escalating rates of drug resistance against a background of growing HIV-epidemic. Samara Oblast is one of the regions of the Russian Federation where more than 1% of the population is affected by the HIV-epidemic; almost half of the cases are concentrated in the largely-industrial city of Togliatti with a population of 800 000.Methods: We conducted a retrospective analysis of errors leading to death of HIV-positive patients in general health care hospitals in Togliatti, Russia, in 2008. All (n = 29) cases when tuberculosis was established at autopsy as a cause of death were included.Results: Median length of hospital stay was 20 days; in 11 cases the death occurred within the first 24 hours of admission. All cases were known to be HIV-positive prior to admission, however HAART was not initiated for any case, and no relevant tests to assess severity of immunosupression were performed despite their availability. No appropriate diagnostic algorithms were applied to confirm tuberculosis. Major gaps were identified in the work of hospital and consulting physicians including insufficient records keeping. In almost all patients earlier regular HIV-relevant tests were not performed due to poor compliance of patients, many of whom abused alcohol and drugs.Conclusions: We conclude that introduction of prompt and accurate diagnostics tests, adequate treatment protocols and intensive training of physicians in management of AIDS and TB is vital. This should include reviewing standards of care for HIV-positive individuals with accompanying social problems. © 2011 Balabanova et al; licensee BioMed Central Ltd.
Kontsevaya I, Mironova S, Nikolayevskyy V, et al., 2011, Evaluation of Two Molecular Assays for Rapid Detection of <i>Mycobacterium tuberculosis</i> Resistance to Fluoroquinolones in High-Tuberculosis and -Multidrug-Resistance Settings, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 49, Pages: 2832-2837, ISSN: 0095-1137
- Author Web Link
- Cite
- Citations: 26
Mitchell SL, Seoudi N, Hutchison DCS, et al., 2011, Multidrug-resistant tuberculosis: resistance rates to first and reserve antituberculosis drugs in the UK in 2008/9 and the role of rapid molecular tests for drug resistance, THORAX, Vol: 66, Pages: 630-631, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 2
Faksri K, Drobniewski F, Nikolayevskyy V, et al., 2011, Genetic diversity of the <i>Mycobacterium tuberculosis</i> Beijing family based on IS<i>6110</i>, SNP, LSP and VNTR profiles from Thailand, INFECTION GENETICS AND EVOLUTION, Vol: 11, Pages: 1142-1149, ISSN: 1567-1348
- Author Web Link
- Cite
- Citations: 32
Bradshaw L, Davies E, Devine M, et al., 2011, The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident, PLOS One, Vol: 6, ISSN: 1932-6203
In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and 98 staff. We investigated for evidence of onward transmission and recent infection based on analysis of clinical, demographic and IGRA data. We also described within-patient variability of IGRA results. Among patients and staff, increasing age of patients was the only factor associated with IGRA positivity. Greatest within-subject variability of IU/mL in serially-tested patients/staff was seen in those with a positive IGRA test and this did not correlate with increased exposure to the index case. IGRA positivity being largely explained by increasing age in patients and previous TB contact in staff lends weight to the conclusion that IGRA positivity reflected previous infection rather than recent transmission. © 2011 Bradshaw et al.
Balabanova Y, Balabanova Y, Nikolayevskyy V, et al., 2011, Survival of Civilian and Prisoner Drug-Sensitive, Multiand Extensive Drug- Resistant Tuberculosis Cohorts Prospectively Followed in Russia, PLOS One, Vol: 6, ISSN: 1932-6203
Objective and Methods: A long-term observational study was conducted in Samara, Russia to assess the survival and risk factors for death of a cohort of non-multidrug resistant tuberculosis (non-MDRTB) and multidrug resistant tuberculosis (MDRTB) civilian and prison patients and a civilian extensive drug-resistant tuberculosis (XDRTB) cohort. Results: MDRTB and XDRTB rates of 54.8% and 11.1% were identified in the region. Half (50%) of MDRTB patients and the majority of non-MDRTB patients (71%) were still alive at 5 years. Over half (58%) of the patients died within two years of establishing a diagnosis of XDRTB. In the multivariate analysis, retreatment (HR = 1.61, 95%CI 1.04, 2.49) and MDRTB (HR = 1.67, 95%CI 1.17, 2.39) were significantly associated with death within the non-MDR/MDRTB cohort. The effect of age on survival was relatively small (HR = 1.01, 95%CI 1.00, 1.02). No specific factor affected survival of XDRTB patients although median survival time for HIV-infected versus HIV-negative patients from this group was shorter (185 versus 496 days). The majority of MDRTB and XDRTB strains (84% and 92% respectively) strains belonged to the Beijing family. Mutations in the rpoB (codon 531 in 81/92; 88.8%), katG (mutation S315T in 91/92, 98.9%) and inhA genes accounted for most rifampin and isoniazid resistance respectively, mutations in the QRDR region of gyrA for most fluroquinolone resistance (68/92; 73.5%). Conclusions: Alarmingly high rates of XDRTB exist. Previous TB treatment cycles and MDR were significant risk factors for mortality. XDRTB patients' survival is short especially for HIV-infected patients. Beijing family strains comprise the majority of drug-resistant strains. © 2011 Balabanova et al.
Mandal S, Bradshaw L, Anderson LF, et al., 2011, Investigating Transmission of <i>Mycobacterium bovis</i> in the United Kingdom in 2005 to 2008, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 49, Pages: 1943-1950, ISSN: 0095-1137
- Author Web Link
- Cite
- Citations: 27
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.