Publications
297 results found
Drobniewski FA, 1998, Diagnosing MDRTB in Britain, British Medical Journal, Vol: 317, Pages: 1263-1264, ISSN: 0959-8138
Drobniewski FA, Eltringham I, 1998, Disseminated Mycobacterium avium-intracellulare in HIV positive patients, Lancet, Vol: 351, Pages: 1059-1060, ISSN: 0140-6736
watterson S, Wilson SM, Yates MD, et al., 1998, Comparison of three molecular assays for rapid detection of rifampin resistance in Mycobacterium tuberculosis, Journal of Clinical Microbiology, Vol: 36, Pages: 1969-1973, ISSN: 0095-1137
Eltringham IJ, Drobniewski F, 1998, Multiple drug resistant tuberculosis: aetiology, diagnosis and outcome, British Medical Bulletin, Vol: 54, Pages: 569-578, ISSN: 0007-1420
Kelly P, Davies SE, Mandanda B, et al., 1997, Enteropathy in Zambians with HIV related diarrhoea: regression modelling of potential determinants of mucosal damage, Gut, Vol: 41, Pages: 811-816, ISSN: 0017-5749
<jats:p><jats:italic>Background</jats:italic>—AIDS is characterised by small intestinal mucosal damage, but its aetiopathogenesis is poorly understood. Enteric infections in Africa differ from those in northern countries, where protozoan infections have been associated with severe enteropathy in AIDS patients.</jats:p><jats:p><jats:italic>Aims</jats:italic>—To characterise enteropathy in Zambian AIDS patients compared with local controls, and to assess relative contributions of enteric infection, nutritional impairment, and immune dysfunction.</jats:p><jats:p><jats:italic>Methods</jats:italic>—Computer aided mucosal morphometry of small intestinal biopsy specimens from 56 HIV infected Zambians with persistent diarrhoea and 26 diarrhoea free controls, followed by regression modelling.</jats:p><jats:p><jats:italic>Results</jats:italic>—Patients with HIV related diarrhoea had reduced villous height and increased crypt depth compared with controls. There was no difference between HIV positive and negative controls. In regression models applied to AIDS mucosal measurements, villous height and crypt depth were related to nutritional parameters and to serum soluble tumour necrosis factor receptor p55 concentration. Crypt depth was also related to lamina propria plasma cell count. Intestinal infection was found in 79%, which consisted predominantly of microsporidia in 34%, <jats:italic>Isospora belli</jats:italic> in 24%, and<jats:italic>Cryptosporidium parvum</jats:italic> in 21%, but detection of these enteropathogens was not related to severity of enteropathy.</jats:p><jats:p><jats:italic>Conclusions</jats:italic>—Nutritional and immune disturbances were associated with enteropathy, accounting for over one third of the variation in mucosal morphometric parameters.</jats:p>
Drobniewski F, Pablos-Méndez A, Raviglione M, 1997, Epidemiology of Tuberculosis in the World, Seminars in Respiratory and Critical Care Medicine, Vol: 18, Pages: 419-429, ISSN: 1069-3424
Baggaley R, Drobniewski F, Pozniak A, et al., 1997, Knowledge and attitudes to HIV and AIDS and sexual practices among university students in Lusaka, Zambia and London, England: are they so different?, J R Soc Health, Vol: 117, Pages: 88-94, ISSN: 0264-0325
Wilson SM, Al-Suwaidi Z, McNerney R, et al., 1997, Evaluation of a new rapid bacteriophage-based method for the drug susceptibility testing of Mycobacterium tuberculosis, Nature Medicine, Vol: 3, Pages: 465-468, ISSN: 1078-8956
Drobniewski FA, Wilson SM, 1997, The Rapid Diagnosis of isoniazid and rifampicin drug resistance in Mycobacterium tuberculosis - a molecular story, Journal of Medical Microbiology, Vol: 47, Pages: 189-196, ISSN: 1473-5644
Drobniewski FA, 1997, Is death inevitable with multidrug resistant TB plus HIV infection, Lancet, Vol: 349, Pages: 71-72, ISSN: 0140-6736
Drobniewski FA, Pozniak AL, 1996, Molecular diagnosis, detection of drug resistance and epidemiology of tuberculosis, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 56, Pages: 204-208, ISSN: 0007-1064
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- Citations: 19
Drobniewski F, Tayler E, Ignatenko N, et al., 1996, Tuberculosis in Siberia .2. Diagnosis, chemoprophylaxis and treatment, TUBERCLE AND LUNG DISEASE, Vol: 77, Pages: 297-301, ISSN: 0962-8479
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- Citations: 19
Drobniewski F, Tayler E, Ignatenko N, et al., 1996, Tuberculosis in Siberia: 1. An epidemiological and microbiological assessment, Tubercle and Lung Disease, Vol: 77, Pages: 199-206, ISSN: 0962-8479
Drobniewski FA, Ferguson J, 1996, Tuberculosis in renal transplant units, Nephrology Dialysis Transplantation, Vol: 11, Pages: 768-770, ISSN: 0931-0509
Drobniewski F, 1995, Tuberculosis in prisons—forgotten plague, The Lancet, Vol: 346, Pages: 948-949, ISSN: 0140-6736
Drobniewski FA, Ferguson J, Barritt K, et al., 1995, Follow up of an immunocompromised contact group of a case of open pulmonary tuberculosis on a renal unit., Thorax, Vol: 50, Pages: 863-868, ISSN: 0040-6376
DROBNIEWSKI FA, POZNIAK AL, UTTLEY AHC, 1995, TUBERCULOSIS AND AIDS, JOURNAL OF MEDICAL MICROBIOLOGY, Vol: 43, Pages: 85-91, ISSN: 0022-2615
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- Citations: 27
Bendall RP, Drobniewski FA, Jayasena SD, et al., 1995, Restriction fragment length polymorphism analysis rules out cross-infection among renal patients with tuberculosis, Journal of Hospital Infection, Vol: 30, Pages: 51-56, ISSN: 0195-6701
Pankhurst CL, Luo N, Kelly P, et al., 1995, Intestinal mycobacteria in African AIDS patients, The Lancet, Vol: 345, Pages: 585-585, ISSN: 0140-6736
Drobniewski F, Kelly P, Carew A, et al., 1995, Human Microsporidiosis in African Aids Patients with Chronic Diarrhea, Journal of Infectious Diseases, Vol: 171, Pages: 515-516, ISSN: 0022-1899
Kelly P, McPhail G, Ngwenya B, et al., 1994, Septata intestinalis: a new microsporidian in Africa, The Lancet, Vol: 344, Pages: 271-272, ISSN: 0140-6736
Drobniewski F, Kahenya G, Msiska R, et al., 1994, Drug Resistance Is Not the Principal Barrier to Effective Control of Tuberculosis in Zambia, The Journal of Infectious Diseases, Vol: 169, Pages: 1180-1181, ISSN: 0022-1899
Drobniewski FA, 1994, The safety of <i>Bacillus</i> species as insect vector control agents, Journal of Applied Bacteriology, Vol: 76, Pages: 101-109, ISSN: 0021-8847
Drobniewski FA, 1993, Bacillus cereus and related species, Clinical Microbiology Reviews, Vol: 6, Pages: 324-338, ISSN: 0893-8512
<jats:p>Bacillus cereus is a gram-positive aerobic or facultatively anaerobic spore-forming rod. It is a cause of food poisoning, which is frequently associated with the consumption of rice-based dishes. The organism produces an emetic or diarrheal syndrome induced by an emetic toxin and enterotoxin, respectively. Other toxins are produced during growth, including phospholipases, proteases, and hemolysins, one of which, cereolysin, is a thiol-activated hemolysin. These toxins may contribute to the pathogenicity of B. cereus in nongastrointestinal disease. B. cereus isolated from clinical material other than feces or vomitus was commonly dismissed as a contaminant, but increasingly it is being recognized as a species with pathogenic potential. It is now recognized as an infrequent cause of serious nongastrointestinal infection, particularly in drug addicts, the immunosuppressed, neonates, and postsurgical patients, especially when prosthetic implants such as ventricular shunts are inserted. Ocular infections are the commonest types of severe infection, including endophthalmitis, panophthalmitis, and keratitis, usually with the characteristic formation of corneal ring abscesses. Even with prompt surgical and antimicrobial agent treatment, enucleation of the eye and blindness are common sequelae. Septicemia, meningitis, endocarditis, osteomyelitis, and surgical and traumatic wound infections are other manifestations of severe disease. B. cereus produces beta-lactamases, unlike Bacillus anthracis, and so is resistant to beta-lactam antibiotics; it is usually susceptible to treatment with clindamycin, vancomycin, gentamicin, chloramphenicol, and erythromycin. Simultaneous therapy via multiple routes may be required.</jats:p>
Drobniewski F, 1993, A Case of Measles — Can Children Refuse Treatment?, Medico-Legal Journal, Vol: 61, Pages: 41-46, ISSN: 0025-8172
Drobniewski FA, 1989, Immunotoxins up to the present day, Bioscience Reports, Vol: 9, Pages: 139-156, ISSN: 0144-8463
<jats:p>Immunotoxins consist of monoclonal or polyclonal antibodies conjugated to bacterial or plant toxins. The toxins used are typically of the A-B type in which a toxic A chain is coupled to a B chain responsible for cell binding and facilitation of A chain entry into the cytosol. Two broad strategies have been followed: coupling intact toxins, or A chains alone, to antibodies. This review examines current progress in in vitro and in vivo research, including recent clinical studies, concentrating principally on ricin or ricin A chain conjugates. The future role of conjugates using membrane-acting toxins, immunolysins, is also discussed.</jats:p>
Drobniewski FA, ellar D, 1989, Purification and properties of a 28KDa haemolytic and mosquitocidal protein toxin of Bacillus thuringiensis., Journal of Bacteriology, Vol: 171, Pages: 3060-3067, ISSN: 0021-9193
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