Imperial College London
Alternate

Professor Francis Drobniewski

Faculty of Medicine, Department of Infectious Disease

Chair in Global Health and Tuberculosis
 
 
 
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Contact

 

f.drobniewski

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Abubakar:2018:10.1016/S1473-3099(18)30355-4,
author = {Abubakar, I and Drobniewski, FA and Southern, J and Sitch, A and Jackson, C and Lipman, M and Deeks, J and Griffiths, C and Bothamley, G and Lynn, W and Burgess, H and Mann, B and Imran, A and Sridhar, S and Tsou, C and Nikolayevskyy, V and Roberts, R and Whitworth, H and Kon, O and Kunst, K and Anderson, S and Watson, J and Haldar, P and Milburn, H and Lalvani, A},
doi = {10.1016/S1473-3099(18)30355-4},
journal = {Lancet Infectious Diseases},
pages = {1077--1087},
title = {Prognostic value of interferon gamma release assays and tuberculin skin test in predicting the development of active tuberculosis: The UK PREDICT TB Cohort Study},
url = {http://dx.doi.org/10.1016/S1473-3099(18)30355-4},
volume = {18},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundTackling tuberculosis (TB) requires testing and treatment latenttuberculosis in high-risk groups. The aim of this study was to estimatethe predictive values of the tuberculin skin test (TST) and interferongamma release assays (IGRAs) for development of active TB .MethodA cohort of migrants and contacts of active TB patients wereprospectively recruited in clinics, the community and primary care. Eachparticipant received three tests (Quantiferon Gold In-Tube [QFT-GIT], TSPOT.TBand TST). A positive TST was reported using three thresholds: 5mm(TST5), 10mm (TST10), and 5mm in BCG-naïve or 15mm in vaccinated (TST15).Participants were followed for a median of 2.9 years. Incident TB caseswere identified by national TB databases, telephone interview, andmedical note review. Outcomes were ratio of incidence rate ratios andpredictive values for TB development.FindingsNinety-seven (1.0%) of 9,610 participants developed active TB (77 of6,380 with results for all 3 tests). In all tests, TB incidence was verylow in test-negatives (1.2-1.6 per 1000 per year). Incidence rates intest-positives were highest for T-SPOT.TB (13.2, 95%CI: (9.9,17.4)),TST15 (11.1 (8.3,14.6)) and QFT-GIT (10.1 (7.4,13.4)). Positive resultsfor these tests were significantly more predictive of progression than TST10 and TST5. However, TST5 identified a higher proportion ofprogressors than TST10, TST15, T-SPOT.TB and QFT-GIT.Interpretation IGRA-based or TST15 strategies appear most suited forscreening. Although TST5 and TST10 detect more TB cases, they alsoclassify more individuals who are unlikely to develop TB as testpositive.Funding source: National Institute for Health Research Health TechnologyAssessment Programme 08-68-01.
AU  - Abubakar,I
AU  - Drobniewski,FA
AU  - Southern,J
AU  - Sitch,A
AU  - Jackson,C
AU  - Lipman,M
AU  - Deeks,J
AU  - Griffiths,C
AU  - Bothamley,G
AU  - Lynn,W
AU  - Burgess,H
AU  - Mann,B
AU  - Imran,A
AU  - Sridhar,S
AU  - Tsou,C
AU  - Nikolayevskyy,V
AU  - Roberts,R
AU  - Whitworth,H
AU  - Kon,O
AU  - Kunst,K
AU  - Anderson,S
AU  - Watson,J
AU  - Haldar,P
AU  - Milburn,H
AU  - Lalvani,A
DO  - 10.1016/S1473-3099(18)30355-4
EP  - 1087
PY  - 2018///
SN  - 1473-3099
SP  - 1077
TI  - Prognostic value of interferon gamma release assays and tuberculin skin test in predicting the development of active tuberculosis: The UK PREDICT TB Cohort Study
T2  - Lancet Infectious Diseases
UR  - http://dx.doi.org/10.1016/S1473-3099(18)30355-4
UR  - http://hdl.handle.net/10044/1/60421
VL  - 18
ER  -
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