Imperial College London
Alternate

Professor Francis Drobniewski

Faculty of Medicine, Department of Infectious Disease

Chair in Global Health and Tuberculosis
 
 
 
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Contact

 

f.drobniewski

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Khimova:2022:10.1080/17476348.2022.2090341,
author = {Khimova, E and Gonzalo, X and Popova, Y and Eliseev, P and Andrey, M and Nikolayevskyy, V and Broda, A and Drobniewski, F},
doi = {10.1080/17476348.2022.2090341},
journal = {Expert Review of Respiratory Medicine},
pages = {615--621},
title = {Urine biomarkers of pulmonary tuberculosis},
url = {http://dx.doi.org/10.1080/17476348.2022.2090341},
volume = {16},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionSputum-based tuberculosis diagnosis does not address the needs of certain categories of patients. Active development of a noninvasive urine-based diagnosis could provide an alternative approach. We reviewed publications covering more than 30 urine biomarkers proposed as significant for TB diagnosis. Analytical approaches were heterogeneous in design and methods; few studies on diagnostic outcome prediction described a formal specificity and sensitivity analysis.Areas coveredThis review describes studies of non-sputum diagnostic approaches of pulmonary TB based on urine using specific TB biomarkers. The search was performed until December 2021, using terms [Tuberculosis] + [urine] + [biomarkers] in PubMed and Cochrane databases. Publications concerning LAM urine diagnostics were excluded as they have been described elsewhere.Expert opinionMicrobiological culture of sputum is considered to be the ‘gold standard’ diagnostic for pulmonary TB but the methodology is slow due to the slow growth of the TB bacteria. Urine provides a large volume of sample. Investigators have evaluated urine for either TB pathogen biomarkers or host biomarkers with some success as the review demonstrates. Detection sensitivity remains a significant problem. In future, combination of host and pathogen biomarkers could increase the sensitivity and specificity of TB diagnosis.
AU  - Khimova,E
AU  - Gonzalo,X
AU  - Popova,Y
AU  - Eliseev,P
AU  - Andrey,M
AU  - Nikolayevskyy,V
AU  - Broda,A
AU  - Drobniewski,F
DO  - 10.1080/17476348.2022.2090341
EP  - 621
PY  - 2022///
SN  - 1747-6348
SP  - 615
TI  - Urine biomarkers of pulmonary tuberculosis
T2  - Expert Review of Respiratory Medicine
UR  - http://dx.doi.org/10.1080/17476348.2022.2090341
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000814155200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.tandfonline.com/doi/full/10.1080/17476348.2022.2090341
VL  - 16
ER  -
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