Imperial College London
Alternate

DrFilipposFilippidis

Faculty of Medicine, School of Public Health

Reader in Public Health
 
 
 
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Contact

 

+44 (0)20 7594 7142f.filippidis

 
 
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Location

 

310Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{D'Anna:2021:10.1002/brb3.2250,
author = {D'Anna, L and Filippidis, FT and Harvey, K and Marinescu, M and Bentley, P and Korompoki, E and Veltkamp, R},
doi = {10.1002/brb3.2250},
journal = {Brain and Behavior},
pages = {1--8},
title = {Extent of white matter lesion is associated with early hemorrhagic transformation in acute ischemic stroke related to atrial fibrillation},
url = {http://dx.doi.org/10.1002/brb3.2250},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundHemorrhagic transformation (HT) after stroke, related to atrial fibrillation (AF), is a frequent complication, and it can be associated with a delay in the (re-)initiation of oral anticoagulation therapy. We investigated the effect of the presence and severity of white matter disease (WMD) on early HT after stroke related to AF.MethodsA consecutive series of patients with recent (<4 weeks) ischemic stroke and AF, treated at the Hyper Acute Stroke Unit of the Imperial College London between 2010 and 2017, were enrolled. Patients with brain MRI performed 24–72 h from stroke onset and not yet started on anticoagulant treatment were included. WMD was graded using the Fazekas score.ResultsAmong the 441 patients eligible for the analysis, 91 (20.6%) had any HT. Patients with and without HT showed similar clinical characteristics. Patients with HT had a larger diffusion-weighted imaging (DWI) infarct volume compared to patients without HT (p < .001) and significant difference in the distribution of the Fazekas score (p = .001). On multivariable analysis, HT was independently associated with increasing DWI infarct volume (odd ratio (OR), 1.03; 95% confidence interval (CI), 1.01–1.05; p < .001), higher Fazekas scores (OR, 1.94; 95% CI, 1.47–2.57; p < .001) and history of previous intracranial hemorrhage (OR, 4.80; 95% CI, 1.11–20.80; p = .036).ConclusionsPresence and severity of WMD is associated with increased risk of development of early HT in patients with stroke and AF. Further evidence is needed to provide reliable radiological predictors of the risk of HT in cardioembolic stroke.
AU  - D'Anna,L
AU  - Filippidis,FT
AU  - Harvey,K
AU  - Marinescu,M
AU  - Bentley,P
AU  - Korompoki,E
AU  - Veltkamp,R
DO  - 10.1002/brb3.2250
EP  - 8
PY  - 2021///
SN  - 2162-3279
SP  - 1
TI  - Extent of white matter lesion is associated with early hemorrhagic transformation in acute ischemic stroke related to atrial fibrillation
T2  - Brain and Behavior
UR  - http://dx.doi.org/10.1002/brb3.2250
UR  - https://onlinelibrary.wiley.com/doi/10.1002/brb3.2250
UR  - http://hdl.handle.net/10044/1/89824
VL  - 11
ER  -
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