Imperial College London
Alternate

Dr Lin Foo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Research Fellow
 
 
 
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Contact

 

f.foo

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mahendru:2017:10.1002/uog.17368,
author = {Mahendru, AA and Foo, FL and McEniery, CM and Everett, TR and Wilkinson, IB and Lees, CC},
doi = {10.1002/uog.17368},
journal = {Ultrasound in Obstetrics & Gynecology},
pages = {78--84},
title = {Change in maternal cardiac output from pre-conception to mid-pregnancy is associated with birth weight in healthy pregnancies},
url = {http://dx.doi.org/10.1002/uog.17368},
volume = {49},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Birth weight (BW) is thought to be determined by maternal health, and genetic, nutritional and placental factors; the latter being influenced by anatomical development and perfusion. Maternal cardiovascular changes contribute to uteroplacental perfusion, however they have not been investigated in relation to fetal growth/BW. Our aim was to explore the relationship between maternal cardiovascular adaptation, fetal growth and BW in healthy pregnancies. METHODS: This was a longitudinal prospective study of women planning to conceive a pregnancy. Maternal cardiac output (CO), cardiac index (CI), pulse-wave velocity, aortic augmentation index (AIx), central blood pressure and peripheral vascular resistance (PVR) were assessed prior to pregnancy and at 6, 23 and 33 weeks' gestation. Fetal growth was assessed by serial ultrasound measurements of biometry. RESULTS: In total, 143 women volunteered to participate and were eligible for study inclusion. One hundred and one women conceived within 18 months and there were 64 live births with normal pregnancy outcome. There were positive correlations between BW and the prepregnancy-to-second trimester changes in CO (ρ = 0.4, P = 0.004), CI (ρ = 0.3, P = 0.02) and PVR (ρ = 0.3, P = 0.02). There were significant associations between third-trimester estimated fetal weight gain and the prepregnancy-to-second trimester increase in CO (Δ, 0.8 ± 1.2 L/min; ρ = 0.3, P = 0.02) and CI (Δ, 0.4 ± 0.6L/min/m(2) ; ρ = 0.3, P = 0.04) and reduction in AIx (Δ, -10 ± 9%; ρ = -0.3, P = 0.04). CONCLUSIONS: In healthy pregnancy, third-trimester fetal growth and BW are associated with incremental changes in maternal CO in early pregnancy. It is plausible that this association is causative, as changes predate third-trimester fetal growth and eventual BW.
AU  - Mahendru,AA
AU  - Foo,FL
AU  - McEniery,CM
AU  - Everett,TR
AU  - Wilkinson,IB
AU  - Lees,CC
DO  - 10.1002/uog.17368
EP  - 84
PY  - 2017///
SN  - 1469-0705
SP  - 78
TI  - Change in maternal cardiac output from pre-conception to mid-pregnancy is associated with birth weight in healthy pregnancies
T2  - Ultrasound in Obstetrics & Gynecology
UR  - http://dx.doi.org/10.1002/uog.17368
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27859800
UR  - http://hdl.handle.net/10044/1/43101
VL  - 49
ER  -
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