Publications
198 results found
Herasimtschuk A, Downey J, Nelson M, et al., 2011, Impact of IL-2/GM-CSF, rhGH and therapeutic immunization in treated HIV-1 infection: a randomized, open-label, Phase I immunotherapeutic study, HIV MEDICINE, Vol: 12, Pages: 27-27, ISSN: 1464-2662
Westrop S, Lagos D, Bower M, et al., 2011, Increased incidence of multicentric Castleman's disease in KSHV<SUP>+</SUP> HIV-1<SUP>+</SUP> individuals of Black African ethnicity may result from the higher frequency of the TLR4 single nucleotide polymorphism A299G, Publisher: WILEY-BLACKWELL, Pages: 6-7, ISSN: 1464-2662
Robey R, Mletzko S, Bower M, et al., 2011, Ex-vivo recognition of late-lytic CD8 epitopes specific for Kaposi's sarcoma-associated herpesvirus (KSHV) by HIV/KSHV-coinfected individuals, HIV MEDICINE, Vol: 12, Pages: 23-23, ISSN: 1464-2662
Benlahrech A, Gotch F, Kelleher P, et al., 2011, Loss of NK Stimulatory Capacity by Plasmacytoid and Monocyte-Derived DC but Not Myeloid DC in HIV-1 Infected Patients, PLOS ONE, Vol: 6, ISSN: 1932-6203
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- Citations: 16
Meys R, Macedo C, Jones R, et al., 2011, Cutaneous human papillomavirus-related immune reconstitution-associated disease in human immunodeficiency virus: an under-recognized phenomenon, BRITISH JOURNAL OF DERMATOLOGY, Vol: 164, Pages: 459-459, ISSN: 0007-0963
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- Citations: 3
Meys R, Bunker C, Gotch FM, et al., 2011, Cutaneous HPV-related immune reconstitution associated disease (IRAD) in HIV: An underrecognized phenomenon, 69th Annual Meeting of the American-Academy-of-Dermatology, Publisher: MOSBY-ELSEVIER, Pages: AB107-AB107, ISSN: 0190-9622
Serwanga J, Mugaba S, Betty A, et al., 2011, CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells <200 Cell/μL: The DART Trial STI Substudy., AIDS Res Treat, Vol: 2011
Objective. To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8(+) T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n = 42) and continuous treatment (CT) (n = 46) before and after a single STI cycle when the DART STI trial was stopped early due to inferior clinical outcome in STI participants. Results. STI and CT had comparable magnitudes and breadths of monofunctional CD8(+)IFNγ(+) and CD8(+)Perforin(+) responses. However, STI was associated with significant decline in breadth of bi-functional (CD8(+)IFNγ(+)Perforin(+)) responses; P = .02, Mann-Whitney test. Conclusions. STI in individuals initiated onto ART at <200 CD4(+) T-cell counts/μl significantly reduced occurrence of bifunctional CD8(+)IFNγ(+)/Perforin(+) responses. These data add to others that found no evidence to support STI as a strategy to improve HIV-specific immunity during ART.
Kaltsidis H, Cheeseman H, Kopycinski J, et al., 2011, Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials, J Immunol Methods, Vol: 370, Pages: 43-54, ISSN: 1872-7905
Grover V, Singh S, Henderson D, et al., 2010, Use of an inflammatory biomarker panel in the diagnosis of Ventilator-Associated Pneumonia, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 122-122, ISSN: 0019-2805
Page EE, Clark S-A, Hart M, et al., 2010, Loss of Th22 cells, rather than a shift from a Th17 to Th1 phenotype, is associated with increased immune activation in HIV-1 infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 123-123, ISSN: 0019-2805
Ford T, Clark SA, Pantelidis P, et al., 2010, IL18R upregulation used in a clinical laboratory approach to identify IFN-γ/IL12 defects in Mendalian Susceptibility to Mycobacterial Disease (MSDM), Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 137-137, ISSN: 0019-2805
Gotch F, Downey J, Herasimtschuk A, et al., 2010, Can novel rational immunotherapy lead to long term non-progressor status in chronically infected HIV plus persons receiving antiretroviral therapy (ART)?, AIDS Vaccine 2010, Publisher: MARY ANN LIEBERT INC, Pages: A89-A89, ISSN: 0889-2229
Duraisingham SS, Hornig J, Gotch F, et al., 2010, CD34-derived human Langerhans cells stimulate a T helper type 2 response independently of extracellular-signal-regulated kinase phosphorylation, IMMUNOLOGY, Vol: 131, Pages: 210-219, ISSN: 0019-2805
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- Citations: 4
Lagos D, Pollara G, Henderson S, et al., 2010, miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator, NATURE CELL BIOLOGY, Vol: 12, Pages: 513-U232, ISSN: 1465-7392
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- Citations: 270
Meys R, Purdie KJ, de Koning MN, et al., 2010, The HPV profile of genital warts in HIV infected patients., Annual Meeting of the Society-for-Investigative-Dermatology, Publisher: NATURE PUBLISHING GROUP, Pages: S125-S125, ISSN: 0022-202X
Krishna SK, Meys R, Purdie KJ, et al., 2010, Carcinoma <i>in-situ</i> of the penis and β-HPV types, Annual Meeting of the Society-for-Investigative-Dermatology, Publisher: NATURE PUBLISHING GROUP, Pages: S27-S27, ISSN: 0022-202X
Meys R, Purdie KJ, de Koning MN, et al., 2010, The HPV profile of cutaneous warts in HIV infected patients, Annual Meeting of the Society-for-Investigative-Dermatology, Publisher: NATURE PUBLISHING GROUP, Pages: S125-S125, ISSN: 0022-202X
Meys R, Gotch FM, Bunker CB, 2010, Human papillomavirus in the era of highly active antiretroviral therapy for human immunodeficiency virus: an immune reconstitution-associated disease?, BRITISH JOURNAL OF DERMATOLOGY, Vol: 162, Pages: 6-11, ISSN: 0007-0963
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- Citations: 23
Spentzou A, Bergin P, Gill D, et al., 2010, Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates, J Infect Dis, Vol: 201, Pages: 720-729, ISSN: 1537-6613
Robey RC, Mletzko S, Gotch FM, 2010, The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus., Adv Virol, Vol: 2010, ISSN: 1687-8639
Kaposi's sarcoma-associated herpesvirus (KSHV) is the aetiological agent of Kaposi's sarcoma (KS), the most frequently arising malignancy in individuals with untreated HIV/AIDS. There are several lines of evidence to indicate that Kaposi's sarcoma oncogenesis is associated with loss of T-cell-mediated control of KSHV-infected cells. KSHV can establish life-long asymptomatic infection in immune-competent individuals. However, when T-cell immune control declines, for example, through AIDS or treatment with immunosuppressive drugs, both the prevalence of KSHV infection and the incidence of KS in KSHV carriers dramatically increase. Moreover, a dramatic and spontaneous improvement in KS is frequently seen when immunity is restored, for example, through antiretroviral therapy or the cessation of iatrogenic drugs. In this paper we describe the current state of knowledge on the T-cell immune responses against KSHV.
Benlahrech A, Harris J, Meiser A, et al., 2009, Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 19940-19945, ISSN: 0027-8424
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- Citations: 123
Benlahrech A, Harris J, Meiser A, et al., 2009, OA07-02. Adenovirus vectors induce expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1 infection, Retrovirology, Vol: 6
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- Citations: 1
Meys R, Mantovani C, Asboe D, et al., 2009, The neurocutaneous environment of warts in HIV infection, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 129, Pages: S103-S103, ISSN: 0022-202X
Duraisingham SS, Hornig J, Gotch F, et al., 2009, TLR-Stimulated CD34 Stem Cell-Derived Human Skin-Like and Monocyte-Derived Dendritic Cells Fail to Induce Th17 Polarization of Naive T Cells but Do Stimulate Th1 and Th17 Memory Responses, JOURNAL OF IMMUNOLOGY, Vol: 183, Pages: 2242-2251, ISSN: 0022-1767
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- Citations: 23
Rosignoli G, Lim CH, Bower M, et al., 2009, Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 157, Pages: 90-97, ISSN: 0009-9104
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- Citations: 38
Robey RC, Lagos D, Gratrix F, et al., 2009, The CD8 and CD4 T-Cell Response against Kaposi's Sarcoma-Associated Herpesvirus Is Skewed Towards Early and Late Lytic Antigens, PLOS One, Vol: 4, ISSN: 1932-6203
Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), the most common malignancy in untreated individuals with HIV/AIDS. The adaptive T-cell immune response against KSHV has not been fully characterized. To achieve a better understanding of the antigenic repertoire of the CD8 and CD4 T-cell responses against KSHV, we constructed a library of lentiviral expression vectors each coding for one of 31 individual KSHV open reading frames (ORFs). We used these to transduce monocyte-derived dendritic cells (moDCs) isolated from 14 KSHV-seropositive (12 HIV-positive) and 7 KSHV-seronegative (4 HIV-positive) individuals. moDCs were transduced with up to 3 KSHV ORFs simultaneously (ORFs grouped according to their expression during the viral life cycle). Transduced moDCs naturally process the KSHV genes and present the resulting antigens in the context of MHC class I and II. Transduced moDCs were cultured with purified autologous T cells and the CD8 and CD4 T-cell proliferative responses to each KSHV ORF (or group) was assessed using a CFSE dye-based assay. Two pools of early lytic KSHV genes ([ORF8/ORF49/ORF61] and [ORF59/ORF65/K4.1]) were frequently-recognized targets of both CD8 and CD4 T cells from KSHV seropositive individuals. One pool of late lytic KSHV genes ([ORF28/ORF36/ORF37]) was a frequently-recognized CD8 target and another pool of late genes ([ORF33/K1/K8.1]) was a frequently-recognized CD4 target. We report that both the CD8 and CD4 T-cell responses against KSHV are skewed towards genes expressed in the early and late phases of the viral lytic cycle, and identify some previously unknown targets of these responses. This knowledge will be important to future immunological investigations into KSHV and may eventually lead to the development of better immunotherapies for KSHV-related diseases.
Buisson S, Benlahrech A, Gazzard B, et al., 2009, Monocyte-Derived Dendritic Cells from HIV Type 1-Infected Individuals Show Reduced Ability to Stimulate T Cells and Have Altered Production of Interleukin (IL)-12 and IL-10, JOURNAL OF INFECTIOUS DISEASES, Vol: 199, Pages: 1862-1871, ISSN: 0022-1899
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- Citations: 39
Westrop SJ, Qazi NA, Pido-Lopez J, et al., 2009, Transient nature of long-term nonprogression and broad virus-specific proliferative T-cell responses with sustained thymic output in HIV-1 controllers, PLOS One, Vol: 4, ISSN: 1932-6203
BackgroundHIV-1+ individuals who, without therapy, conserve cellular anti-HIV-1 responses, present with high, stable CD4+ T-cell numbers, and control viral replication, facilitate analysis of atypical viro-immunopathology. In the absence of universal definition, immune function in such HIV controllers remains an indication of non-progression.Methodology/Principal FindingsCD4 T-cell responses to a number of HIV-1 proteins and peptide pools were assessed by IFN-γ ELISpot and lymphoproliferative assays in HIV controllers and chronic progressors. Thymic output was assessed by sjTRECs levels. Follow-up of 41 HIV-1+ individuals originally identified as “Long-term non-progressors” in 1996 according to clinical criteria, and longitudinal analysis of two HIV controllers over 22 years, was also performed. HIV controllers exhibited substantial IFN-γ producing and proliferative HIV-1-specific CD4 T-cell responses to both recombinant proteins and peptide pools of Tat, Rev, Nef, Gag and Env, demonstrating functional processing and presentation. Conversely, HIV-specific T-cell responses were limited to IFN-γ production in chronic progressors. Additionally, thymic output was approximately 19 fold higher in HIV controllers than in age-matched chronic progressors. Follow-up of 41 HIV-1+ patients identified as LTNP in 1996 revealed the transitory characteristics of this status. IFN-γ production and proliferative T-cell function also declines in 2 HIV controllers over 22 years.ConclusionsAlthough increased thymic output and anti-HIV-1 T-cell responses are observed in HIV controllers compared to chronic progressors, the nature of nonprogressor/controller status appears to be transitory
Meys R, Fowles F, Little A, et al., 2009, Immunogenetics of HIV associated HPV disease after HAART, 69th Annual Meeting of the Society-of-Investigative-Dermatology, Publisher: NATURE PUBLISHING GROUP, Pages: S82-S82, ISSN: 0022-202X
Meys R, Purdie KJ, de Koning MN, et al., 2009, Beta human papillomvirus (beta-HPV) types are common in persistent warts in HAART treated HIV positive individuals, 69th Annual Meeting of the Society-of-Investigative-Dermatology, Publisher: NATURE PUBLISHING GROUP, Pages: S30-S30, ISSN: 0022-202X
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