Imperial College London
Alternate

ProfessorFrancesGotch

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 3315 8257f.gotch

 
 
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Assistant

 

Mrs Julie James +44 (0)20 3315 8258

 
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Location

 

J 2 12Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Publication Type
Year
to

198 results found

Serwanga J, Shafer LA, Pimego E, Auma B, Watera C, Rowland S, Yirrell D, Pala P, Grosskurth H, Whitworth J, Gotch F, Kaleebu Pet al., 2009, Host HLA B*Allele-Associated Multi-Clade Gag T-Cell Recognition Correlates with Slow HIV-1 Disease Progression in Antiretroviral Therapy-Naive Ugandans, PLOS ONE, Vol: 4, ISSN: 1932-6203

Journal article

Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, Morghen CDG, De Maria A, De Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, Mcclure M, Miller N, Mingari MC, Moretta L, Noonan D, O'Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robert-Guroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, Van Lunzen J, Varnier O, Vicenzi E, Von Melchner H, Witz I, Zagury D, Zagury J-F, Zauli G, Zipeto Det al., 2009, Unsung Hero Robert C. Gallo, SCIENCE, Vol: 323, Pages: 206-207, ISSN: 0036-8075

Journal article

Gregson JNS, Steel A, Bower M, Gazzard BG, Gotch FM, Goodier MRet al., 2009, Elevated plasma lipopolysaccharide is not sufficient to drive natural killer cell activation in HIV-1-infected individuals, AIDS, Vol: 23, Pages: 29-34, ISSN: 0269-9370

Journal article

Benlahrech A, Donaghy H, Rozis G, Goodier M, Klavinskis L, Gotch F, Patterson Set al., 2009, Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways, SENSORS, Vol: 9, Pages: 386-403, ISSN: 1424-8220

Journal article

Kyosiimire-Lugemwa J, Pala P, Miiro G, Todd J, Kaleebu P, Imami N, Gotch Fet al., 2009, Gag and Nef specific T-cell responses in HIV-1 infected long-term non-progressors in Uganda, RETROVIROLOGY, Vol: 6, ISSN: 1742-4690

Journal article

Benlahrech A, Harris J, Meiser A, Papagatsias T, Hornig J, Hayes P, Lieber A, Athanasopoulos T, Bachy V, Daniels R, Fisher K, Gotch F, Klavinskis L, Seymour L, Logan K, Barbagallo R, Dickson G, Patterson Set al., 2009, Adenovirus vectors induce expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1 infection, RETROVIROLOGY, Vol: 6, ISSN: 1742-4690

Journal article

Duraisingham SS, Gotch F, Patterson S, 2008, Human CD34-derived Langerhans cells preferentially induce IL-17-producing T-helper cells compared to dermal-type DCs and monocyte-derived DCs, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 99-99, ISSN: 0019-2805

Conference paper

Clark SA, Ford T, Henderson DC, Nelson M, Hawkins D, Gotch F, Gazzard B, Kelleher Pet al., 2008, Impairment of CD<sub>4</sub> T Cell cytokine responses to PPD in HIV infection, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL, Pages: 143-144, ISSN: 0019-2805

Conference paper

Lagos D, Vart RJ, Gratix F, Westrop SJ, Emuss V, Wong PP, Robey R, Imami N, Bower M, Gotch F, Boshoff Cet al., 2008, Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus., Cell Host & Microbe, Vol: 4, Pages: 470-483

The involvement of Toll-like receptor 4 (TLR4) in immunity against human herpesviruses has not been previously demonstrated. We show that infection of endothelial cells with Kaposi sarcoma herpesvirus (KSHV), a human oncogenic virus, leads to rapid suppression of TLR4 expression. This is a mechanism of immune escape as TLR4 mediates innate immunity against KSHV. In vitro, cells lacking TLR4 are more susceptible to KSHV infection, whereas activation of TLR4 protects cells from infection. In vivo, HIV-1-infected individuals carrying a mutant TLR4 allele appear more likely to have multicentric Castleman's disease, a lymphoproliferation associated with enhanced KSHV replication. ERK activation by KSHV structural proteins and the KSHV-encoded vGPCR plays a key role in the TLR4 downregulation, whereas the KSHV vIRF1 also contributes to this effect. Our findings reveal a role for TLR4 in innate immunity against herpesviruses and suggest the potential use of TLR4 agonists for the treatment of KSHV-related neoplasms.

Journal article

Gudmundsdotter L, Bostrom A-C, Burton C, Rosignoli G, Sandstrom E, Hejdeman B, Wahren B, Imami N, Gotch Fet al., 2008, Long-term increase of CD4<SUP>+</SUP> central memory cells in HIV-1-infected individuals by therapeutic HIV-1 rgp160 immunization, VACCINE, Vol: 26, Pages: 5107-5110, ISSN: 0264-410X

Journal article

Rozis G, Benlahrech A, Duraisingham S, Gotch F, Patterson Set al., 2008, Human Langerhans' cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands, IMMUNOLOGY, Vol: 124, Pages: 329-338, ISSN: 0019-2805

Journal article

Burton CT, Goodall RL, Samri A, Autran B, Kelleher AD, Poli G, Pantaleo G, Gotch FM, Imami Net al., 2008, Restoration of anti-tetanus toxoid responses in patients initiating highly active antiretroviral therapy with or without a boost immunization: an INITIO substudy, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 152, Pages: 252-257, ISSN: 0009-9104

Journal article

Steel A, Clark S-A, Hart M, Henderson D, Gotch F, Gazzard B, Kelleher Pet al., 2008, Loss of memory B cell subsets in uncomplicated adult coeliac disease, GASTROENTEROLOGY, Vol: 134, Pages: A521-A521, ISSN: 0016-5085

Journal article

Meys R, Asboe D, Gotch FM, Bunker CBet al., 2008, HPV associated mucocutaneous disease post HAART/IRD - patient immunophenotype, International Investigative Dermatology Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S190-S190, ISSN: 0022-202X

Conference paper

Steel A, Clark SA, Hart M, Henderson D, Gotch F, Gazzard B, Kelleher Pet al., 2008, Loss of memory B cell subsets in uncomplicated adult coeliac disease, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Pages: A521-A521

Conference paper

Steel A, John L, Shamji MH, Henderson DC, Gotch FM, Gazzard BG, Kelleher Pet al., 2008, CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy, HIV MEDICINE, Vol: 9, Pages: 118-125, ISSN: 1464-2662

Journal article

Papagatsias T, Rozis G, Athanasopoulos T, Gotch F, Dickson G, Patterson Set al., 2008, Activity of different vaccine-associated promoter elements in human dendritic cells, IMMUNOLOGY LETTERS, Vol: 115, Pages: 117-125, ISSN: 0165-2478

Journal article

Gotch F, Hayes P, Bergin P, 2008, Current strategies to test HIV vaccines, 7th Euroconference on Clinical Cell Analysis, Publisher: WILEY-LISS, Pages: 56-56, ISSN: 1552-4949

Conference paper

Lacson E, Lazarus JM, Panlitio R, Gotch Fet al., 2008, Comparison of hemodialysis blood access flow rates using online measurement of conductivity dialysance and ultrasound dilution, AMERICAN JOURNAL OF KIDNEY DISEASES, Vol: 51, Pages: 99-106, ISSN: 0272-6386

Journal article

Guimaraes-Walker A, Mackie N, McCormack S, Hanke T, Schmidt C, Gilmour J, Barin B, McMichael A, Weber J, Legg K, Babiker A, Hayes P, Gotch F, Smith C, Dally L, Dorrell L, Cebere I, Kay R, Winstone N, Moore S, Goonetilleke N, Fast P, Group ISet al., 2008, Lessons from IAVI-006, a phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers, Vaccine, Vol: 26, Pages: 6671-6677, ISSN: 0264-410X

Journal article

Gotch F, 2008, What is important in dialysis? Efficiency: Blood flow, KoA and Kt/V?, HEMODIALYSIS: FROM BASIC RESEARCH TO CLINICAL TRIALS, Vol: 161, Pages: 168-177, ISSN: 0302-5144

Journal article

Gotch F, 2008, Calcium and phosphorus kinetics in hemodialysis therapy, HEMODIALYSIS: FROM BASIC RESEARCH TO CLINICAL TRIALS, Vol: 161, Pages: 210-214, ISSN: 0302-5144

Journal article

Cronin-Fine D, Gotch F, Levin NW, Kotanko P, Lysaght Met al., 2007, A mathematical model comparing solute kinetics in low- and high-BMI hemodialysis patients, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, Vol: 30, Pages: 1000-1007, ISSN: 0391-3988

Journal article

Mela CM, Steel A, Lindsay J, Gazzard BG, Gotch FM, Goodier MRet al., 2007, Depletion of natural killer cells in the colonic lamina propria of viraemic HIV-1 infected individuals., AIDS, Vol: 21, Pages: 2177-2182

Journal article

Rosignoli G, Cranage A, Burton C, Nelson M, Steel A, Gazzard B, Gotch F, Imami Net al., 2007, Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients, AIDS, Vol: 21, Pages: 1379-1381, ISSN: 0269-9370

Journal article

Hart M, Steel A, Clark SA, Moyle G, Nelson M, Henderson DC, Wilson R, Gotch F, Gazzard B, Kelleher Pet al., 2007, Loss of discrete memory B cell subsets is associated with impaired immunization responses in HIV-1 infection and may be a risk factor for invasive pneumococcal disease, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 8212-8220, ISSN: 0022-1767

Journal article

Gotch F, 2007, Kenneth Anthony ("Tony") Kalanyi Kebba - Obituary, BRITISH MEDICAL JOURNAL, Vol: 334, Pages: 1227-1227, ISSN: 0959-8146

Journal article

Hardy GA, Imami N, Nelson MR, Sullivan AK, Moss R, Aasa-Chapman MM, Gazzard B, Gotch FMet al., 2007, A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy, Journal of Immune Based Therapies and Vaccines, Vol: 5, ISSN: 1476-8518

BackgroundFully functional HIV-1-specific CD8 and CD4 effector T-cell responses are vital to the containment of viral activity and disease progression. These responses are lacking in HIV-1-infected patients with progressive disease. We attempted to augment fully functional HIV-1-specific CD8 and CD4 effector T-cell responses in patients with advanced chronic HIV-1 infection.DesignChronically infected patients with low CD4 counts T-cell counts who commenced antiretroviral therapy (ART) were subsequently treated with combined interleukin-2 and therapeutic vaccination.MethodsThirty six anti-retroviral naive patients were recruited and initiated on combination ART for 17 weeks before randomization to: A) ongoing ART alone; B) ART with IL-2 twice daily for 5 days every four weeks starting at week 17 for 3 cycles; C) ART with IL-2 as in group B and Remune HIV-1 vaccine administered once every 3 months, starting at week 17; and D) ART with Remune vaccine as in group C. Patients were studied for 65 weeks following commencement of ART, with an additional prior 6 week lead-in observation period. CD4 and CD8 T-cell counts, evaluations of HIV-1 RNA levels and proliferative responses to recall and HIV-1 antigens were complemented with assessment of IL-4-secretion alongside quantification of anti-HIV-1 CD8 T-cell responses and neutralizing antibody titres.ResultsNeither IL-2 nor Remune™ vaccination induced sustained HIV-1-specific T-cell responses. However, we report an inverse relationship between HIV-1-specific proliferative responses and IL-4 production which continuously increased in patients receiving immunotherapy, but not patients receiving ART alone.ConclusionInduction of HIV-1-specific cell-mediated responses is a major challenge in chronically HIV-1-infected patients even when combining immunisation with IL-2 therapy. An antigen-specific IL-4-associated suppressive response may play a role in attenuating HIV-specific responses.

Journal article

Kebba A, Imami N, Bugembe-Lule D, Senkaali D, Kaleebu P, Grosskurth H, Gotch Fet al., 2007, Recent HIV-1 infection in a high-risk Ugandan cohort: implications for Phase IIB test-of-concept HIV vaccine trials, PHARMACOGENOMICS, Vol: 8, Pages: 409-414, ISSN: 1462-2416

Journal article

Gilmour J, Stevens G, Gill D, Tarragona T, Seamons L, Birungi J, Kato PK, Semaganda A, Anzala O, Farah B, Ogola S, Indangasi J, Mhlanga P, Ndzamela N, Thakar M, Pujari A, Purandare B, Mishra S, Goonetilleke N, Moore S, Mahmoud A, Gotch F, Styles T, Stout J, Dally L, Boaz MJ, Hayes Pet al., 2007, Laboratory development and assay standardization for the evaluation of HIV vaccines in Africa and India, 6th Euroconference on Clinical Cell Analysis, Publisher: WILEY-LISS, Pages: 120-120, ISSN: 1552-4949

Conference paper

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