Publications
198 results found
Tchilian EZ, Wallace DL, Imami N, et al., 2001, The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans., J. Immunol, Vol: 166, Pages: 6144-6148
Worrell S, Deayton J, Hayes P, et al., 2001, Molecular correlates in AIDS patients following antiretroviral therapy: diversified T-cell receptor repertoires and in vivo control of cytomegalovirus replication., HIV Med, Vol: 2, Pages: 11-19, ISSN: 1464-2662
OBJECTIVES: To evaluate whether successful, long-term immune reconstitution in vivo can be achieved in end-stage AIDS patients following antiretroviral therapy (ART). METHODS: A 1-year prospective study of changes of CD4+ and CD8+ T-cell surface phenotypes, T-cell receptor (TCR) repertoires and capacity to control in vivo replication of cytomegalovirus (CMV) was performed in five treatment-naive end-stage AIDS patients (median CD4+ T-cell counts of 19 cells/microL) following therapy. Proportions of CD45RA+, CD45RO+ and CD28+ cells within the CD4+ and CD8+ subsets, were determined by flow cytometry. Changes in TCR Vbeta repertoires within the CD4+ and CD8+ T-cell compartments were evaluated using CDR3 spectratyping. CMV replication was determined by a sensitive polymerase chain reaction (PCR) assay using whole blood. RESULTS: Following ART, proportionate increases in 'naive' (CD45RA+) and 'memory' (CD45RO+) T cells were observed within both CD4+ and CD8+ T-cell subsets, while increased numbers of CD28+ T cells were mainly observed within the CD4+ subset. Diversification of CD4+ and CD8+ TCR repertoires was established concomitantly with renewed in vivo control of CMV replication. CONCLUSIONS: An important degree of molecular and functional immune recovery is possible in end-stage AIDS patients introduced to therapy. Diversification of TCR repertoires and the in vivo restoration of immunocompetence to control opportunistic infections clearly show that an important degree of molecular immune reconstitution is established following the initiation of ART even in late-stage AIDS.
Morgan D, Kaleebu P, Whitworth J, et al., 2001, The stability between two HIV-1 RNA measurements one year apart and the relationship with HIV subtype in rural Uganda, Int J STD AIDS, Vol: 12, Pages: 116-121, ISSN: 0956-4624
Gotch F, Burton C, Donaghy H, et al., 2001, Novel approaches to the treatment of HIV, HIV & AIDS Current Trends, Vol: 7, ISSN: 1358-8370
Gilmour JW, Gilling-Smith C, Gotch F, 2001, Reduction of HIV transmission in HIV-discordant couples wishing to conceive, AIDS, Vol: 15, Pages: 429-430, ISSN: 0269-9370
Jones GJ, Watera C, Patterson S, et al., 2001, Comparative loss and maturation of peripheral blood dendritic cell subpopulations in African and non-African HIV-1-infected patients, AIDS, Vol: 15, Pages: 1657-1663, ISSN: 0269-9370
Wilkinson J, Gotch F, 2001, Immune interventions, BRITISH MEDICAL BULLETIN, Vol: 58, Pages: 187-203, ISSN: 0007-1420
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- Citations: 1
Patterson S, Rae A, Hockey N, et al., 2001, Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus, J Virol, Vol: 75, Pages: 6710-6713, ISSN: 0022-538X
Donaghy H, Pozniak A, Gazzard B, et al., 2001, Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load, Blood, Vol: 98, Pages: 2574-2576, ISSN: 0006-4971
Mallon E, Bunce M, Savoie H, et al., 2000, HLA-C and guttate psoriasis, BRITISH JOURNAL OF DERMATOLOGY, Vol: 143, Pages: 1177-1182, ISSN: 0007-0963
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- Citations: 71
Sullivan AK, Pires A, Hardy GAD, et al., 2000, Phenotypic T cell changes in HIV-1 infected individuals receiving highly active antiretroviral therapy, AIDS, Vol: 14, Pages: S75-S75, ISSN: 0269-9370
Sullivan AK, Imami N, Hardy GAD, et al., 2000, Acute viral load blips in response to subcutaneous interleukin-2 therapy in HIV-1 infected individuals on highly active antiretroviral therapy, AIDS, Vol: 14, Pages: S73-S74, ISSN: 0269-9370
Wilson JDK, Imami N, Watkins A, et al., 2000, Loss of CD4<SUP>+</SUP> T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to disease, JOURNAL OF INFECTIOUS DISEASES, Vol: 182, Pages: 792-798, ISSN: 0022-1899
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- Citations: 105
Ibrahim MAA, Gotch FM, 2000, Making smarter immunotherapies, NATURE IMMUNOLOGY, Vol: 1, Pages: 3-3, ISSN: 1529-2908
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- Citations: 3
Hayes PJ, Miao YM, Gotch FM, et al., 1999, Alterations in blood leucocyte adhesion molecule profiles in HIV-1 infection, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 117, Pages: 331-334, ISSN: 0009-9104
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- Citations: 21
Kim LU, Johnson MR, Barton S, et al., 1999, Evaluation of sperm washing as a potential method of reducing HIV transmission in HIV-discordant couples wishing to have children, AIDS, Vol: 13, Pages: 645-651, ISSN: 0269-9370
Obi A, Imami N, Gotch F, et al., 1998, Cytomegalovirus retinitis in AIDS patients with persistently low CD4 counts receiving HAART, Association for Research in Vision and Ophthalmology annual meeting, Publisher: Association for Research in Vision and Ophthalmology, ISSN: 1552-5783
PHILLIPS RE, ROWLANDJONES S, NIXON DF, et al., 1991, HUMAN-IMMUNODEFICIENCY-VIRUS GENETIC-VARIATION THAT CAN ESCAPE CYTOTOXIC T-CELL RECOGNITION, NATURE, Vol: 354, Pages: 453-459, ISSN: 0028-0836
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- Citations: 964
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