Publications
198 results found
Meys R, Bunker C, Gotch FM, et al., 2011, Cutaneous HPV-related immune reconstitution associated disease (IRAD) in HIV: An underrecognized phenomenon, 69th Annual Meeting of the American-Academy-of-Dermatology, Publisher: MOSBY-ELSEVIER, Pages: AB107-AB107, ISSN: 0190-9622
Serwanga J, Mugaba S, Betty A, et al., 2011, CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells <200 Cell/μL: The DART Trial STI Substudy., AIDS Res Treat, Vol: 2011
Objective. To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8(+) T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n = 42) and continuous treatment (CT) (n = 46) before and after a single STI cycle when the DART STI trial was stopped early due to inferior clinical outcome in STI participants. Results. STI and CT had comparable magnitudes and breadths of monofunctional CD8(+)IFNγ(+) and CD8(+)Perforin(+) responses. However, STI was associated with significant decline in breadth of bi-functional (CD8(+)IFNγ(+)Perforin(+)) responses; P = .02, Mann-Whitney test. Conclusions. STI in individuals initiated onto ART at <200 CD4(+) T-cell counts/μl significantly reduced occurrence of bifunctional CD8(+)IFNγ(+)/Perforin(+) responses. These data add to others that found no evidence to support STI as a strategy to improve HIV-specific immunity during ART.
Kaltsidis H, Cheeseman H, Kopycinski J, et al., 2011, Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials, J Immunol Methods, Vol: 370, Pages: 43-54, ISSN: 1872-7905
Grover V, Singh S, Henderson D, et al., 2010, Use of an inflammatory biomarker panel in the diagnosis of Ventilator-Associated Pneumonia, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 122-122, ISSN: 0019-2805
Page EE, Clark S-A, Hart M, et al., 2010, Loss of Th22 cells, rather than a shift from a Th17 to Th1 phenotype, is associated with increased immune activation in HIV-1 infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 123-123, ISSN: 0019-2805
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