Imperial College London
Alternate

ProfessorFrancesGotch

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 3315 8257f.gotch

 
 
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Assistant

 

Mrs Julie James +44 (0)20 3315 8258

 
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Location

 

J 2 12Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Guergnon:2012:infdis/jir833,
author = {Guergnon, J and Dalmasso, C and Broet, P and Meyer, L and Westrop, SJ and Imami, N and Vicenzi, E and Morsica, G and Tinelli, M and Zanone, Poma B and Goujard, C and Potard, V and Gotch, FM and Casoli, C and Cossarizza, A and Macciardi, F and Debré, P and Delfraissy, JF and Galli, M and Autran, B and Costagliola, D and Poli, G and Theodorou, I and Riva, A},
doi = {infdis/jir833},
journal = {Journal of Infectious Diseases},
pages = {718--724},
title = {Single-nucleotide polymorphism-defined Class I and Class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection},
url = {http://dx.doi.org/10.1093/infdis/jir833},
volume = {205},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1–infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1–infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate, <0.05) with the LTNP condition, among which 5 reached genome-wide significance after Bonferonni correction. The MHC LTNP–associated SNPs are ordered in ≥4 linkage disequilibrium blocks; interestingly, an MHC class III linkage disequilibrium block (defined by the rs9368699 SNP) seems specific to the LTNP phenotype.
AU  - Guergnon,J
AU  - Dalmasso,C
AU  - Broet,P
AU  - Meyer,L
AU  - Westrop,SJ
AU  - Imami,N
AU  - Vicenzi,E
AU  - Morsica,G
AU  - Tinelli,M
AU  - Zanone,Poma B
AU  - Goujard,C
AU  - Potard,V
AU  - Gotch,FM
AU  - Casoli,C
AU  - Cossarizza,A
AU  - Macciardi,F
AU  - Debré,P
AU  - Delfraissy,JF
AU  - Galli,M
AU  - Autran,B
AU  - Costagliola,D
AU  - Poli,G
AU  - Theodorou,I
AU  - Riva,A
DO  - infdis/jir833
EP  - 724
PY  - 2012///
SN  - 0022-1899
SP  - 718
TI  - Single-nucleotide polymorphism-defined Class I and Class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jir833
UR  - https://academic.oup.com/jid/article/205/5/718/838523
VL  - 205
ER  -
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