Imperial College London
Alternate

Dr Francine Heatley

Faculty of Medicine, Department of Surgery & Cancer

Clinical Trials Manager
 
 
 
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Contact

 

+44 (0)20 3311 7371f.heatley Website

 
 
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Location

 

3E4East WingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shalhoub:2017:10.1016/j.ejvs.2017.02.013,
author = {Shalhoub, J and Norrie, J and Baker, C and Bradbury, AW and Dhillon, K and Everington, T and Gohel, M and Hamady, Z and Heatley, F and Hudson, J and Hunt, BJ and Stansby, G and Stephens-Boal, A and Warwick, D and Davies, AH},
doi = {10.1016/j.ejvs.2017.02.013},
journal = {European Journal of Vascular and Endovascular Surgery},
pages = {880--885},
title = {Graduated compression stockings as an adjunct to low dose low molecular weight heparin in venous thromboembolism prevention in surgery– a multi-centre randomised controlled trial},
url = {http://dx.doi.org/10.1016/j.ejvs.2017.02.013},
volume = {53},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:The evidence base upon which current global venous thromboembolism (VTE) prevention recommendations have been made is not optimal. The cost of purchasing and applying Graduated Compression Stockings (GCS) in surgical patients is considerable and has been estimated at £63.1 million each year in England alone.Objective:To determine whether low dose low molecular weight heparin (LMWH) alone is non-inferior to a combination of GCS and low dose LMWH for the prevention of VTE.Methods:A randomised controlled Graduated compression as an Adjunct to Pharmacoprophylaxis in Surgery (GAPS) Trial [ISRCTN 13911492] will randomise adult elective surgical patients identified as being at moderate and high risk for VTE to receive either the current ‘standard’ combined thromboprophylactic LMWH with GCS mechanical thromboprophylaxis, or thromboprophylactic LMWH pharmacoprophylaxis alone. To show non-inferiority (3.5% non-inferiority margin) for the primary endpoint of all VTE within 90 days, 2236 patients are required. Recruitment will be from seven UK centres. Secondary outcomes include quality of life, compliance with stockings and LMWH, overall mortality, and GCS or LMWH-related complications (including bleeding).Recruitment commenced in April 2016 with the seven UK centres coming ‘on-line’ in a staggered fashion. Recruitment will be over a total of 18 months. The GAPS trial is funded by the National Institute for Health Research Health Technology Assessment in the UK [14/140/61].
AU  - Shalhoub,J
AU  - Norrie,J
AU  - Baker,C
AU  - Bradbury,AW
AU  - Dhillon,K
AU  - Everington,T
AU  - Gohel,M
AU  - Hamady,Z
AU  - Heatley,F
AU  - Hudson,J
AU  - Hunt,BJ
AU  - Stansby,G
AU  - Stephens-Boal,A
AU  - Warwick,D
AU  - Davies,AH
DO  - 10.1016/j.ejvs.2017.02.013
EP  - 885
PY  - 2017///
SN  - 1532-2165
SP  - 880
TI  - Graduated compression stockings as an adjunct to low dose low molecular weight heparin in venous thromboembolism prevention in surgery– a multi-centre randomised controlled trial
T2  - European Journal of Vascular and Endovascular Surgery
UR  - http://dx.doi.org/10.1016/j.ejvs.2017.02.013
UR  - http://hdl.handle.net/10044/1/44442
VL  - 53
ER  -
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