Summary
Selected Publications
Journal Articles
Harrod A, Fulton J, Nguyen VTM, et al. , 2016, Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer, Oncogene, Vol:36, ISSN:1476-5594, Pages:2286-2296
Patel H, Abduljabbar R, Lai CF, et al. , 2016, CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor- positive breast cancer, Clinical Cancer Research, Vol:22, ISSN:1557-3265, Pages:5929-5938
Periyasamy M, Patel H, Lai C-F, et al. , 2015, APOBEC3B mediated cytidine deamination is required for estrogen receptor action in breast cancer, Cell Reports, Vol:13, ISSN:2211-1247, Pages:108-121
Kramer H, Lai C, Dattani H, et al. , 2015, LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner, Nucleic Acids Research, Vol:44, ISSN:1362-4962, Pages:582-594
Lin M-L, Patel H, Remenyi J, et al. , 2015, Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer, Oncotarget, Vol:6, ISSN:1949-2553, Pages:21685-21703
Abduljabbar R, Negm OH, Lai C-F, et al. , 2015, Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer, Breast Cancer Research and Treatment, Vol:150, ISSN:0167-6806, Pages:335-346
Lai C-F, Flach KD, Alexi X, et al. , 2013, Co-regulated gene expression by oestrogen receptor alpha and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells, Nucleic Acids Research, Vol:41, ISSN:0305-1048, Pages:10228-10240
Rey J, Hu H, Kyle F, et al. , 2012, Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation, Chemmedchem, Vol:7, ISSN:1860-7179, Pages:1909-1914
Tolhurst RS, Thomas RS, Kyle FJ, et al. , 2011, Transient over-expression of estrogen receptor-alpha in breast cancer cells promotes cell survival and estrogen-independent growth, Breast Cancer Research and Treatment, Vol:128, ISSN:0167-6806, Pages:357-368
Thiruchelvam PTR, Lai C-F, Hua H, et al. , 2011, The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells, Breast Cancer Research and Treatment, Vol:127, ISSN:0167-6806, Pages:385-396
Thiruchelvam P, Photiou A, Fui LC, et al. , 2009, Characterization of the nuclear receptor LRH-1 reveals a new form that can function in estrogen regulated breast cancer cell growth, Cancer Research, Vol:69, ISSN:0008-5472