Dr Chun Fui Lai

Harrod A, Fulton J, Nguyen VTM, et al.Harrod A, Fulton J, Nguyen VTM, Periyasamy M, Ramos Garcia L, Lai C-F, Metodieva G, de Giorgio A, Williams RL, Santos DB, Jimenez Gomez P, Lin M-L, Metodiev MV, Stebbing J, Castellano L, Magnani L, Coombes RC, Buluwela L, Ali S close, 2016, Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer, Oncogene, Vol:36, ISSN:1476-5594, Pages:2286-2296

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Patel H, Abduljabbar R, Lai CF, et al.Patel H, Abduljabbar R, Lai CF, Periyasamy M, Harrod A, Gemma C, Steel J, Patel N, Busonero C, Jerjees D, Remenyi J, Smith S, Gomm JJ, Magnani L, Gyorffy B, Jones JL, Fuller-Pace FV, Shousha S, Buluwela L, Rakha EA, Ellis IO, Coombes RC, Ali S, Patel H, Abduljabbar R, Chun-Fui L, Periyasamy M, Harrod A, Gemma C, Steel JH, Patel N, Busonero C, Jerjees D, Remenyi J, Smith S, Gomm JJ, Magnani L, Győrffy B, Jones LJ, Fuller-Pace F, Shousha S, Buluwela L, Rakha EA, Ellis IO, Coombes RC, Ali S close, 2016, CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor- positive breast cancer, Clinical Cancer Research, Vol:22, ISSN:1557-3265, Pages:5929-5938

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Periyasamy M, Patel H, Lai C-F, et al.Periyasamy M, Patel H, Lai C-F, Nguyen VTM, Nevedomskaya E, Harrod A, Russell R, Remenyi J, Ochocka AM, Thomas RS, Fuller-Pace F, Gyorffy B, Caldas C, Navaratnam N, Carroll JS, Zwart W, Coombes RC, Magnani L, Buluwela L, Ali S close, 2015, APOBEC3B mediated cytidine deamination is required for estrogen receptor action in breast cancer, Cell Reports, Vol:13, ISSN:2211-1247, Pages:108-121

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Kramer H, Lai C, Dattani H, et al.Kramer H, Lai C, Dattani H, Periyasamy M, Lin M, Ali S, Buluwela L close, 2015, LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner, Nucleic Acids Research, Vol:44, ISSN:1362-4962, Pages:582-594

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Lin M-L, Patel H, Remenyi J, et al.Lin M-L, Patel H, Remenyi J, Banerji CRS, Lai C-F, Periyasamy M, Lombardo Y, Busonero C, Ottaviani S, Passey A, Quinlan PR, Purdie CA, Jordan LB, Thompson AM, Finn RS, Rueda OM, Caldas C, Gil J, Coombes RC, Fuller-Pace FV, Teschendorff AE, Buluwela L, Ali S close, 2015, Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer, Oncotarget, Vol:6, ISSN:1949-2553, Pages:21685-21703

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Abduljabbar R, Negm OH, Lai C-F, et al.Abduljabbar R, Negm OH, Lai C-F, Jerjees DA, Al-Kaabi M, Hamed MR, Tighe PJ, Buluwela L, Mukherjee A, Green AR, Ali S, Rakha EA, Ellis IO close, 2015, Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer, Breast Cancer Research and Treatment, Vol:150, ISSN:0167-6806, Pages:335-346

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Lai C-F, Flach KD, Alexi X, et al.Lai C-F, Flach KD, Alexi X, Fox SP, Ottaviani S, Thiruchelvam PTR, Kyle FJ, Thomas RS, Launchbury R, Hua H, Callaghan HB, Carroll JS, Coombes RC, Zwart W, Buluwela L, Ali S close, 2013, Co-regulated gene expression by oestrogen receptor alpha and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells, Nucleic Acids Research, Vol:41, ISSN:0305-1048, Pages:10228-10240

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Rey J, Hu H, Kyle F, et al.Rey J, Hu H, Kyle F, Lai C-F, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AGM close, 2012, Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation, Chemmedchem, Vol:7, ISSN:1860-7179, Pages:1909-1914

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Tolhurst RS, Thomas RS, Kyle FJ, et al.Tolhurst RS, Thomas RS, Kyle FJ, Patel H, Periyasamy M, Photiou A, Thiruchelvam PTR, Lai C-F, Al-Sabbagh M, Fisher RA, Barry S, Crnogorac-Jurcevic T, Martin L-A, Dowsett M, Coombes RC, Kamalati T, Ali S, Buluwela L close, 2011, Transient over-expression of estrogen receptor-alpha in breast cancer cells promotes cell survival and estrogen-independent growth, Breast Cancer Research and Treatment, Vol:128, ISSN:0167-6806, Pages:357-368

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Thiruchelvam PTR, Lai C-F, Hua H, et al.Thiruchelvam PTR, Lai C-F, Hua H, Thomas RS, Hurtado A, Hudson W, Bayly AR, Kyle FJ, Periyasamy M, Photiou A, Spivey AC, Ortlund EA, Whitby RJ, Carroll JS, Coombes RC, Buluwela L, Ali S close, 2011, The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells, Breast Cancer Research and Treatment, Vol:127, ISSN:0167-6806, Pages:385-396

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Thiruchelvam P, Photiou A, Fui LC, et al.Thiruchelvam P, Photiou A, Fui LC, Coombes C, Ali S, Buluwela L close, 2009, Characterization of the nuclear receptor LRH-1 reveals a new form that can function in estrogen regulated breast cancer cell growth, Cancer Research, Vol:69, ISSN:0008-5472

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