Imperial College London

Dr Chun Fui Lai

Faculty of MedicineDepartment of Surgery & Cancer

Research Associate







Institute of Reproductive and Developmental BiologyHammersmith Campus





Selected Publications

Journal Articles

Harrod A, Fulton J, Nguyen VTM, et al., 2016, Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer, Oncogene, Vol:36, ISSN:1476-5594, Pages:2286-2296

Patel H, Abduljabbar R, Lai CF, et al., 2016, CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor- positive breast cancer, Clinical Cancer Research, Vol:22, ISSN:1557-3265, Pages:5929-5938

Periyasamy M, Patel H, Lai C-F, et al., 2015, APOBEC3B mediated cytidine deamination is required for estrogen receptor action in breast cancer, Cell Reports, Vol:13, ISSN:2211-1247, Pages:108-121

Kramer H, Lai C, Dattani H, et al., 2015, LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner, Nucleic Acids Research, Vol:44, ISSN:1362-4962, Pages:582-594

Lin M-L, Patel H, Remenyi J, et al., 2015, Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer, Oncotarget, Vol:6, ISSN:1949-2553, Pages:21685-21703

Abduljabbar R, Negm OH, Lai C-F, et al., 2015, Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer, Breast Cancer Research and Treatment, Vol:150, ISSN:0167-6806, Pages:335-346

Lai C-F, Flach KD, Alexi X, et al., 2013, Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells, Nucleic Acids Research, Vol:41, ISSN:0305-1048, Pages:10228-10240

Rey J, Hu H, Kyle F, et al., 2012, Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation, Chemmedchem, Vol:7, ISSN:1860-7179, Pages:1909-1914

Tolhurst RS, Thomas RS, Kyle FJ, et al., 2011, Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth, Breast Cancer Research and Treatment, Vol:128, ISSN:0167-6806, Pages:357-368

Thiruchelvam PTR, Lai C-F, Hua H, et al., 2011, The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells, Breast Cancer Research and Treatment, Vol:127, ISSN:0167-6806, Pages:385-396

Thiruchelvam P, Photiou A, Fui LC, et al., 2009, Characterization of the nuclear receptor LRH-1 reveals a new form that can function in estrogen regulated breast cancer cell growth, Cancer Research, Vol:69, ISSN:0008-5472

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