Imperial College London

Dr Fu Siong Ng

Faculty of MedicineNational Heart & Lung Institute

Clinical Senior Lecturer in Cardiac Electrophysiology
 
 
 
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Contact

 

+44 (0)20 7594 3614f.ng Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

109 results found

Ng FS, Shadi IT, Peters NS, Lyon ARet al., 2010, Ivabradine reduces the incidence of reperfusion ventricular fibrillation following regional ischaemia: insights into anti-arrhythmic protective effect from optical mapping, European Society of Cardiology (ESC), Pages: 1043-1043

Conference paper

Ng FS, Lyon AR, Shadi IT, Chang ETY, Chowdhury RA, Duopnt E, Peters NSet al., 2010, Modulation of Gap Junctional Coupling as an Anti-Arrhythmic Strategy to Prevent Reperfusion Arrhythmias, British Cardiovascular Society Annual Conference 2010, Pages: A2-A3

Conference paper

Ng FS, Lyon AR, Shadi IT, Chang ETY, Chowdhury RA, Dupont E, Peters NSet al., 2010, Gap Junction Modulation - An Anti-Arrhythmic Strategy to Prevent Reperfusion VF, 31st Annual Scientific Sessions of the Heart Rhythm Society (HRS), Pages: S353-S353

Conference paper

Ng FS, Lyon AR, Shadi IT, Chang ETY, Chowdhury RA, Dupont E, Peters NS, Ng FS, Lyon AR, Shadi IT, Chang ETY, Chowdhury RA, Dupont E, Peters NSet al., 2010, Moderate gap junctional uncoupling with carbenoxolone slows conduction and increases vulnerability to ventricular arrhythmias—an optical mapping study, 6th Annual Congress of the European Cardiac Arrhythmia Society (April 2010), Pages: 234-234

It is uncertain whether moderate conductionslowing through gap junctional uncoupling on its own, inthe absence of action potential or structural changes, issufficient to be pro-arrhythmic. We used optical mapping:(1) to study the effects of carbenoxolone (CBX), a gapjunction uncoupler, on conduction velocity and actionpotential duration and (2) to assess the effects of moderateconduction slowing and gap junctional uncoupling onarrhythmia vulnerability in structurally normal hearts.Methods: Rat hearts (n = 12) were perfused on aLangendorff apparatus, loaded with a voltage-sensitivedye (RH237) and perfused with an excitation–contractionuncoupler (10 μM blebbistatin). Transmembrane voltagetransients were recorded using a 256-photodiode array.Hearts were then perfused with 30 μM CBX (n=6) orcontrol (n=6) for 30 min and epicardial activation mappedevery 2 min during ventricular pacing. Subsequently, heartswere subjected to programmed ventricular stimulation andassigned an inducibility quotient depending on ease ofarrhythmia inducibility. Results: CBX slowed conductionvelocity (conduction velocity index: baseline 100%, CBX70±2%, P<0.01), with no change in control hearts after30 min (baseline 100%, controls 98±3%, P=NS). CBX didnot affect action potential duration (APD90: baseline 90±3 ms, CBX 94±5 ms, P=NS). Inducibility of ventriculararrhythmias was increased in CBX hearts compared withcontrol hearts (inducibility quotient: CBX 5.0±1.0, control2.5±1.0, P<0.05). Conclusions: Gap junctional uncouplingwith CBX produced a 30% reduction in conductionvelocity without changes in action potential duration andresulted in increased arrhythmia vulnerability. These results suggest that moderate conduction slowing produced by gap junctional uncoupling in isolation, i.e. in the absence of changes in action potential duration or structural abnormalities, is sufficient to increase susceptibility to ventricular arrhythmias.

Conference paper

Nicholson-Thomas D, Chowdhury RA, Ng FS, Dupont E, Lyon AR, Peters NSet al., 2010, A novel approach to visualising three-dimensional connexin43 distribution in a rat infarct model, 6th Annual Congress of the European Cardiac Arrhythmia Society, Pages: 172-173

Conference paper

Chang ETY, Ng FS, Chowdhury RA, Inuabasi L, Dupont E, Peters NSet al., 2010, Carbenoxolone limits increase in Connexin43 expression in ischaemic rat ventricular tissue, 6th Annual Congress of the European Cardiac Arrhythmia Society, Pages: 234-235

Conference paper

Ng FS, Lyon AR, Shadi IT, Chang ETY, Chowdhury RA, Dupont E, Peters NSet al., 2010, Modulation of gap junctional coupling as an antiarrhythmic strategy to prevent reperfusion ventricular arrhythmias, 6th Congress of the European Cardiac Arrhythmia Society, Publisher: Springer Verlag, Pages: 173-174, ISSN: 1572-8595

Conference paper

Chowdhury RA, Inuabasi L, Kirubakaran S, Hall MCS, Ng FS, Garratt CJ, Peters NSet al., 2010, Structural and Electrical Remodelling as a Mechanism of the "Second Factor" in the Self-Perpetuation of Atrial Fibrilation: A Study in a Chronic Goat Model, SET for Britain 2010 (House of Commons, UK Parliament)

Conference paper

Ng FS, Lyon AR, Chowdhury RA, Dupont E, Peters NSet al., 2010, Pharmacological Modulation of Gap Junctional Coupling with AAP10 and Carbenoxolone Reduces the Incidence and Delays the Onset of Reperfusion Arrhythmias Following Regional Ischaemia, Medical Research Society Meeting 2010, Pages: 4P-4P

Conference paper

Chowdhury RA, Dias P, Inuabasi L, Ng F, Ullrich N, MacLeod K, Dupont E, Peters NSet al., 2009, Gap junction uncoupling by carbenoxolone administration leads to reversible conduction slowing in Hl-1 cardiomyocytes, Heart Rhythm Congress 2009, Pages: iv18-iv18

Conference paper

Ng FS, Lyon AR, Chowdhury RA, Dupont E, Peters NSet al., 2009, Modulating gap junctional coupling with AAP10 and carbenoxolone reduces the incidence and delays the onset of reperfusion arrhythmias following regional ischaemia, Heart Rhythm Congress 2009, Pages: iv1-iv1

Conference paper

Ng FS, Lyon AR, Chowdhury RA, Kontogeorgis A, Peters NSet al., 2009, Two phases of arrhythmic risk in the first four weeks post-myocardial infarction in rats, 5th Annual Congress of the European Cardiac Arrhythmia Society, Pages: 191-192

Conference paper

Bucciarelli-Ducci C, Ng FS, Symmonds K, Reyes E, Schultz C, Kaddoura S, Prasad SKet al., 2008, The complex pathophysiology of acute myocardial infarction imaged by cardiovascular magnetic resonance - Infarction, edema, microvascular obstruction, and inducible ischemia, CIRCULATION, Vol: 118, Pages: E89-E92, ISSN: 0009-7322

Journal article

Flather M, Connolly S, Hohnloser S, Flaker G, Goldhaber S, Ng FS, Pfeffer M, Yusuf Set al., 2007, Risks and patterns of bleeding in patients with atrial fibrillation, European Society of Cardiology Congress 2007, Pages: 534-534

Conference paper

Wechalekar K, Ng FS, Poole-Wilson PA, Duncan A, Nutting C, Naidoo VV, Underwood SRet al., 2007, Cardiac amyloidosis diagnosed incidentally by bone scintigraphy, JOURNAL OF NUCLEAR CARDIOLOGY, Vol: 14, Pages: 750-753, ISSN: 1071-3581

Journal article

Hasan KM, Manyonda IT, Ng FS, Singer DRJ, Antonios TFTet al., 2002, Skin capillary density changes in normal pregnancy and pre-eclampsia, JOURNAL OF HYPERTENSION, Vol: 20, Pages: 2439-2443, ISSN: 0263-6352

Journal article

Ng FS, Camm AJ, 2002, Catheter ablation of atrial fibrillation, CLINICAL CARDIOLOGY, Vol: 25, Pages: 384-394, ISSN: 0160-9289

Journal article

Ng FS, Triay JM, Iqbal K, Singh N, Antonios TFT, Manyonda IT, Singer DRJet al., 2001, Leptin and capillary density in health and in pregnancy, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 533, Pages: 78P-78P, ISSN: 0022-3751

Journal article

Iqbal K, Hui CM, Ng FS, Triay J, Ward ST, Singer DRJet al., 2001, Capillary surface area and tortuosity increases with ageing in healthy subjects, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 533, Pages: 77P-78P, ISSN: 0022-3751

Journal article

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