Dr Fu Siong Ng is a Clinical Senior Lecturer in Cardiac Electrophysiology at Imperial College London, and a Consultant Cardiologist at Imperial College Healthcare NHS Trust and Chelsea and Westminster Hospital NHS Foundation Trust. He is a Clinician Scientist and currently leads a programme of research into arrhythmogenic mechanisms alongside performing invasive ablation procedures and implanting pacemakers and defibrillators in patients with heart rhythm disorders. Dr Ng is also the Programme Director for the intercalated BSc in Cardiovascular Sciences at Imperial College London.
Dr Ng studied Medicine at St. George’s, University of London, where he was awarded a First Class (Honours) BSc degree in Medical Sciences & Clinical Pharmacology and achieved Distinctions at his Final MBBS Examinations. He received his post-graduate clinical training in Cardiology and Cardiac Electrophysiology at Hammersmith and St. Mary’s Hospitals. Dr Ng was awarded his PhD by Imperial College London for his work on the effects of gap junction modulation on the post-infarct arrhythmic substrate, funded by an MRC Clinical Research Training Fellowship. He then conducted post-doctoral research at Washington University in Saint Louis, funded by a BHF Travel Fellowship, investigating the arrhythmogenic remodelling in heart failure by performing optical mapping experiments on explanted human hearts, before returning to Imperial, firstly as an NIHR Clinical Lecturer and now as a Clinical Senior Lecturer. Dr Ng is accredited as a Cardiac Electrophysiology Specialist with the European Heart Rhythm Association and is a Fellow of the European Society of Cardiology.
Dr Ng is currently an Executive director of the ElectroCardioMaths Programme. He has attracted >£2.8 million in external research funding, published >40 peer-reviewed research papers and won 14 research prizes.
Dr Ng’s research spans the bench-to-bedside spectrum, and his current research interests include:
- The electroarchitectural determinants of myocardial fibrillatory dynamics (PhD student: Balvinder Handa, post-doc: Xinyang Li)
- The role of inflammation and auto-immunity on arrhythmogenesis (PhD student: Catherine Jenkins, post-doc: David Pitcher)
- Ventricular electrophysiological remodelling in bariatric patients and in DCM patients with titin-truncating mutations (PhD student: Kiran Patel)
- First-in-man studies on low-energy defibrillation for atrial fibrillation (link)
- Ursodeoxycholic acid as an anti-fibrotic and anti-arrhythmic agent (PhD student: Elisa Ferraro)
- The role of the Purkinje-myocardial junctions in ventricular arrhythmogenesis
Dr Ng is active in both undergraduate and postgraduate teaching and supervision at Imperial and has supervised 9 PhD students at Imperial.
et al., 2020, Ventricular fibrillation mechanism and global fibrillatory organisation are determined by gap junction coupling and fibrosis pattern, Cardiovascular Research, ISSN:0008-6363
et al., 2020, Granger causality-based analysis for classification of fibrillation mechanisms and localisation of rotational drivers, Circulation: Arrhythmia and Electrophysiology, Vol:12, ISSN:1941-3084, Pages:258-273
et al., 2019, Standardised framework for quantitative analysisof fibrillation dynamics, Scientific Reports, Vol:9, ISSN:2045-2322
et al., 2017, ST-Elevation Magnitude Correlates With Right Ventricular Outflow Tract Conduction Delay in Type I Brugada ECG, Circulation: Arrhythmia and Electrophysiology, Vol:10, ISSN:1941-3084
et al., 2017, Spatial resolution requirements for accurate identification of drivers of atrial fibrillation, Circulation-arrhythmia and Electrophysiology, Vol:10, ISSN:1941-3084
et al., 2016, Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility, Jacc. Clinical Electrophysiology, Vol:2, ISSN:2405-5018, Pages:574-582
et al., 2014, Adverse Remodeling of the Electrophysiological Response to Ischemia-Reperfusion in Human Heart Failure Is Associated With Remodeling of Metabolic Gene Expression, Circulation-Arrhythmia and Electrophysiology, Vol:7, ISSN:1941-3149, Pages:875-U234
et al., 2014, c-Src Kinase Inhibition Reduces Arrhythmia Inducibility and Connexin43 Dysregulation After Myocardial Infarction, Journal of the American College of Cardiology, Vol:63, ISSN:0735-1097, Pages:928-934
et al., 2013, Selective heart rate reduction with ivabradine slows ischaemia-induced electrophysiological changes and reduces ischaemia-reperfusion-induced ventricular arrhythmias, Journal of Molecular and Cellular Cardiology, Vol:59, ISSN:0022-2828, Pages:67-75
et al., 2012, Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes, American Journal of Physiology - Heart and Circulatory Physiology, Vol:303, ISSN:0363-6135, Pages:H753-H765