Imperial College London

Dr Fu Siong Ng

Faculty of MedicineNational Heart & Lung Institute

Clinical Senior Lecturer in Cardiac Electrophysiology



+44 (0)20 7594 Website




ICTEM buildingHammersmith Campus






BibTex format

author = {Ng, FS and Handa, B and Li, X and Peters, N},
doi = {10.3389/fphys.2020.00987},
journal = {Frontiers in Physiology},
pages = {1--7},
title = {Towards mechanism-directed electrophenotype-based treatments for atrial fibrillation},
url = {},
volume = {11},
year = {2020}

RIS format (EndNote, RefMan)

AB - Current treatment approaches for persistent atrial fibrillation (AF) have a ceiling of success of around 50%. This is despite 15 years of developing adjunctive ablation strategies in addition to pulmonary vein isolation to target the underlying arrhythmogenic substrate in AF. A major shortcoming of our current approach to AF treatment is its predominantly empirical nature. This has in part been due to a lack of consensus on the mechanisms that sustain human AF.6 In this article, we review evidence suggesting that the previous debates on AF being eitheran organised arrhythmia with a focal driver ora disorganised rhythm sustained by multiple wavelets, may prove to be a false dichotomy. Instead,a range of fibrillation electrophenotypes exists along a continuous spectrum, and the predominant mechanism in an individual case is determined by the nature and extent of remodelling of the underlying substrate. We propose moving beyond the current empirical approach to AF treatment, and highlight the need to prescribe AF treatments based on the underlying AFelectrophenotype, and review several possible novel mapping algorithms that may be useful in discerning the AF electrophenotype to guide tailored treatments, including Granger Causality mapping.
AU - Ng,FS
AU - Handa,B
AU - Li,X
AU - Peters,N
DO - 10.3389/fphys.2020.00987
EP - 7
PY - 2020///
SN - 1664-042X
SP - 1
TI - Towards mechanism-directed electrophenotype-based treatments for atrial fibrillation
T2 - Frontiers in Physiology
UR -
UR -
UR -
VL - 11
ER -