Imperial College London

Dr Fu Siong Ng

Faculty of MedicineNational Heart & Lung Institute

Clinical Senior Lecturer in Cardiac Electrophysiology



+44 (0)20 7594 Website




ICTEM buildingHammersmith Campus






BibTex format

author = {Leong, KMW and Ng, FS and Shun-Shin, MJ and Koa-Wing, M and Qureshi, N and Whinnett, ZI and Linton, NF and Lefroy, D and Francis, DP and Harding, SE and Davies, DW and Peter, NS and Lim, PB and Behr, E and Lambiase, PD and Varnava, A and Kanagaratnam, P},
doi = {europace/euaa248},
journal = {Europace},
title = {Non-invasive detection of exercise-induced cardiac conduction abnormalities in sudden cardiac death survivors in the inherited cardiac conditions.},
url = {},
year = {2020}

RIS format (EndNote, RefMan)

AB - AIMS : Rate adaptation of the action potential ensures spatial heterogeneities in conduction across the myocardium are minimized at different heart rates providing a protective mechanism against ventricular fibrillation (VF) and sudden cardiac death (SCD), which can be quantified by the ventricular conduction stability (V-CoS) test previously described. We tested the hypothesis that patients with a history of aborted SCD due to an underlying channelopathy or cardiomyopathy have a reduced capacity to maintain uniform activation following exercise. METHODS AND RESULTS : Sixty individuals, with (n = 28) and without (n = 32) previous aborted-SCD event underwent electro-cardiographic imaging recordings following exercise treadmill test. These included 25 Brugada syndrome, 13 hypertrophic cardiomyopathy, 12 idiopathic VF, and 10 healthy controls. Data were inputted into the V-CoS programme to calculate a V-CoS score that indicate the percentage of ventricle that showed no significant change in ventricular activation, with a lower score indicating the development of greater conduction heterogeneity. The SCD group, compared to those without, had a lower median (interquartile range) V-CoS score at peak exertion [92.8% (89.8-96.3%) vs. 97.3% (94.9-99.1%); P < 0.01] and 2 min into recovery [95.2% (91.1-97.2%) vs. 98.9% (96.9-99.5%); P < 0.01]. No significant difference was observable later into recovery at 5 or 10 min. Using the lowest median V-CoS scores obtained during the entire recovery period post-exertion, SCD survivors had a significantly lower score than those without for each of the different underlying aetiologies. CONCLUSION : Data from this pilot study demonstrate the potential use of this technique in risk stratification for the inherited cardiac conditions.
AU - Leong,KMW
AU - Ng,FS
AU - Shun-Shin,MJ
AU - Koa-Wing,M
AU - Qureshi,N
AU - Whinnett,ZI
AU - Linton,NF
AU - Lefroy,D
AU - Francis,DP
AU - Harding,SE
AU - Davies,DW
AU - Peter,NS
AU - Lim,PB
AU - Behr,E
AU - Lambiase,PD
AU - Varnava,A
AU - Kanagaratnam,P
DO - europace/euaa248
PY - 2020///
TI - Non-invasive detection of exercise-induced cardiac conduction abnormalities in sudden cardiac death survivors in the inherited cardiac conditions.
T2 - Europace
UR -
UR -
ER -