Imperial College London
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Dr Fu Siong Ng

Faculty of Medicine, National Heart & Lung Institute

Reader in Cardiac Electrophysiology
 
 
 
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Contact

 

+44 (0)20 7594 3614f.ng Website

 
 
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Location

 

430ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nagy:2022:10.1007/s13239-021-00568-1,
author = {Nagy, SZ and Kasi, P and Afonso, VX and Bird, N and Pederson, B and Mann, IE and Kim, S and Linton, NWF and Lefroy, DC and Whinnett, Z and Ng, FS and Koa-Wing, M and Kanagaratnam, P and Peters, NS and Qureshi, NA and Lim, PB},
doi = {10.1007/s13239-021-00568-1},
journal = {Cardiovascular Engineering and Technology},
pages = {219--233},
title = {Cycle length evaluation in persistent atrial fibrillation using kernel density estimation to identify transient and stable rapid atrial activity},
url = {http://dx.doi.org/10.1007/s13239-021-00568-1},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeLeft atrial (LA) rapid AF activity has been shown to co-localise with areas of successful atrial fibrillation termination by catheter ablation. We describe a technique that identifies rapid and regular activity.MethodsEight-second AF electrograms were recorded from LA regions during ablation for psAF. Local activation was annotated manually on bipolar signals and where these were of poor quality, we inspected unipolar signals. Dominant cycle length (DCL) was calculated from annotation pairs representing a single activation interval, using a probability density function (PDF) with kernel density estimation. Cumulative annotation duration compared to total segment length defined electrogram quality. DCL results were compared to dominant frequency (DF) and averaging.ResultsIn total 507 8 s AF segments were analysed from 7 patients. Spearman’s correlation coefficient was 0.758 between independent annotators (P < 0.001), 0.837–0.94 between 8 s and ≥ 4 s segments (P < 0.001), 0.541 between DCL and DF (P < 0.001), and 0.79 between DCL and averaging (P < 0.001). Poorer segment organization gave greater errors between DCL and DF.ConclusionDCL identifies rapid atrial activity that may represent psAF drivers. This study uses DCL as a tool to evaluate the dynamic, patient specific properties of psAF by identifying rapid and regular activity. If automated, this technique could rapidly identify areas for ablation in psAF.
AU  - Nagy,SZ
AU  - Kasi,P
AU  - Afonso,VX
AU  - Bird,N
AU  - Pederson,B
AU  - Mann,IE
AU  - Kim,S
AU  - Linton,NWF
AU  - Lefroy,DC
AU  - Whinnett,Z
AU  - Ng,FS
AU  - Koa-Wing,M
AU  - Kanagaratnam,P
AU  - Peters,NS
AU  - Qureshi,NA
AU  - Lim,PB
DO  - 10.1007/s13239-021-00568-1
EP  - 233
PY  - 2022///
SN  - 1869-408X
SP  - 219
TI  - Cycle length evaluation in persistent atrial fibrillation using kernel density estimation to identify transient and stable rapid atrial activity
T2  - Cardiovascular Engineering and Technology
UR  - http://dx.doi.org/10.1007/s13239-021-00568-1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000690377800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs13239-021-00568-1
UR  - http://hdl.handle.net/10044/1/93797
VL  - 13
ER  -
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