Imperial College London
Portrait Picture

Dr Fu Siong Ng

Faculty of Medicine, National Heart & Lung Institute

Reader in Cardiac Electrophysiology
 
 
 
//

Contact

 

+44 (0)20 7594 3614f.ng Website

 
 
//

Location

 

430ICTEM buildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Kappadan:2023:10.1113/JP283683,
author = {Kappadan, V and Sohi, A and Parlitz, U and Luther, S and Uzelac, I and Fenton, F and Peters, NS and Christoph, J and Ng, FS},
doi = {10.1113/JP283683},
journal = {The Journal of Physiology},
pages = {1353--1370},
title = {Optical mapping of contracting hearts},
url = {http://dx.doi.org/10.1113/JP283683},
volume = {601},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Optical mapping is a widely used tool to record and visualize the electrophysiological properties in a variety of myocardial preparations such as Langendorff-perfused isolated hearts, coronary-perfused wedge preparations, and cell culture monolayers. Motion artifact originating from the mechanical contraction of the myocardium creates a significant challenge to performing optical mapping of contracting hearts. Hence, to minimize the motion artifact, cardiac optical mapping studies are mostly performed on non-contracting hearts, where the mechanical contraction is removed using pharmacological excitation–contraction uncouplers. However, such experimental preparations eliminate the possibility of electromechanical interaction, and effects such as mechano-electric feedback cannot be studied. Recent developments in computer vision algorithms and ratiometric techniques have opened the possibility of performing optical mapping studies on isolated contracting hearts. In this review, we discuss the existing techniques and challenges of optical mapping of contracting hearts.
AU  - Kappadan,V
AU  - Sohi,A
AU  - Parlitz,U
AU  - Luther,S
AU  - Uzelac,I
AU  - Fenton,F
AU  - Peters,NS
AU  - Christoph,J
AU  - Ng,FS
DO  - 10.1113/JP283683
EP  - 1370
PY  - 2023///
SN  - 0022-3751
SP  - 1353
TI  - Optical mapping of contracting hearts
T2  - The Journal of Physiology
UR  - http://dx.doi.org/10.1113/JP283683
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000954417500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP283683
UR  - http://hdl.handle.net/10044/1/104418
VL  - 601
ER  -
Download