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@article{Noormohamed:1996,
author = {Noormohamed, FH and Youle, MS and Tang, B and Martin-Munley, S and Gazzard, BG and Lant, AF},
journal = {Antivir Ther},
pages = {172--179},
title = {Foscarnet-induced changes in plasma concentrations of total and ionized calcium and magnesium in HIV-positive patients.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/11322251},
volume = {1},
year = {1996}
}

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TY  - JOUR
AB  - The time course and magnitude of foscarnet-induced changes in plasma concentrations of total and ionized calcium and magnesium were investigated in 13 male HIV-positive patients who had no active cytomegalovirus-associated disease. The patients had a mean age of 36 years (range 25-49 years) and a mean CD4 cell count of 550 cells/mm3 (range 130-1280 cells/mm3). Peak (mean +/- SD) plasma concentrations of foscarnet (0.89+/-0.10 mmol/l) were seen at the end of the period of drug infusion (90 mg/kg of foscarnet was infused over 2 hours) and declined with a terminal half-life of 5.7+/-0.7 hours. Plasma concentrations of total calcium declined over an 8-hour period, with the lowest concentration occurring after 4 hours (baseline: 2.29+/-0.09 mmol/l; lowest: 2.18+/-0.07 mmol/l; P < 0.001). By contrast, the lowest plasma concentration of ionized calcium occurred after 2 hours (baseline: 1.25+/-0.04 mmol/l; lowest: 0.99+/-0.05 mmol/l; P < 0.001), before gradually recovering to baseline levels over the next 10 hours. The mean maximal decrease in total calcium was 0.11+/-0.06 mmol/l, compared with 0.26+/-0.04 mmol/l for ionized calcium (P < 0.001). Plasma concentrations of total magnesium declined from 0.79+/-0.06 mmol/l (baseline) to 0.74+/-0.04 mmol/l (P < 0.05) after 4 hours and remained at this level after 8 hours. However, plasma concentrations of ionized magnesium fell steeply from 0.56+/-0.03 mmol/l to 0.39+/-0.03 mmol/l at 2 hours (P < 0.001), followed by a gradual recovery over the next 10 hours. The mean maximal decrease in total magnesium was 0.05+/-0.08 mmol/l, compared with 0.18+/-0.03 mmol/l (P < 0.001) for ionized magnesium. In summary, we found that foscarnet-induced changes in the plasma concentrations of total calcium and magnesium were dissociated from the corresponding changes in ionized calcium and magnesium. The maximal decreases in the plasma concentrations of total calcium and magnesium were smaller in magnitude and occurred much later
AU  - Noormohamed,FH
AU  - Youle,MS
AU  - Tang,B
AU  - Martin-Munley,S
AU  - Gazzard,BG
AU  - Lant,AF
EP  - 179
PY  - 1996///
SN  - 1359-6535
SP  - 172
TI  - Foscarnet-induced changes in plasma concentrations of total and ionized calcium and magnesium in HIV-positive patients.
T2  - Antivir Ther
UR  - https://www.ncbi.nlm.nih.gov/pubmed/11322251
VL  - 1
ER  -

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