Imperial College London
Dr Felipe Orihuela-Espina

DrFelipeOrihuela-Espina

Faculty of Medicine, Department of Surgery & Cancer

Honorary Lecturer
 
 
 
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Publications

Citation

BibTex format

@inproceedings{Herrera-Vega:2017:10.1117/12.2285918,
author = {Herrera-Vega, J and Montero-Hernandez, S and Tachtsidis, I and Trevino-Palacios, CG and Orihuela-Espina, F},
doi = {10.1117/12.2285918},
publisher = {Society of Photo-Optical Instrumentation Engineers (SPIE)},
title = {Modelling and validation of diffuse reflectance of the adult human head for fNIRS: scalp sub-layers definition},
url = {http://dx.doi.org/10.1117/12.2285918},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Accurate estimation of brain haemodynamics parameters such as cerebral blood flow and volume as well as oxygen consumption i.e. metabolic rate of oxygen, with funcional near infrared spectroscopy (fNIRS) requires precise characterization of light propagation through head tissues. An anatomically realistic forward model of the human adult head with unprecedented detailed specification of the 5 scalp sublayers to account for blood irrigation in the connective tissue layer is introduced. The full model consists of 9 layers, accounts for optical properties ranging from 750nm to 950nm and has a voxel size of 0.5mm. The whole model is validated comparing the predicted remitted spectra, using Monte Carlo simulations of radiation propagation with 108 photons, against continuous wave (CW) broadband fNIRS experimental data. As the true oxy- and deoxy-hemoglobin concentrations during acquisition are unknown, a genetic algorithm searched for the vector of parameters that generates a modelled spectrum that optimally fits the experimental spectrum. Differences between experimental and model predicted spectra was quantified using the Root mean square error (RMSE). RMSE was 0.071 ± 0.004, 0.108 ± 0.018 and 0.235±0.015 at 1, 2 and 3cm interoptode distance respectively. The parameter vector of absolute concentrations of haemoglobin species in scalp and cortex retrieved with the genetic algorithm was within histologically plausible ranges. The new model capability to estimate the contribution of the scalp blood flow shall permit incorporating this information to the regularization of the inverse problem for a cleaner reconstruction of brain hemodynamics.
AU  - Herrera-Vega,J
AU  - Montero-Hernandez,S
AU  - Tachtsidis,I
AU  - Trevino-Palacios,CG
AU  - Orihuela-Espina,F
DO  - 10.1117/12.2285918
PB  - Society of Photo-Optical Instrumentation Engineers (SPIE)
PY  - 2017///
SN  - 0277-786X
TI  - Modelling and validation of diffuse reflectance of the adult human head for fNIRS: scalp sub-layers definition
UR  - http://dx.doi.org/10.1117/12.2285918
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000419981400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69915
ER  -
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