Imperial College London
Dr Felipe Orihuela-Espina

DrFelipeOrihuela-Espina

Faculty of Medicine, Department of Surgery & Cancer

Honorary Lecturer
 
 
 
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Publications

Citation

BibTex format

@article{Wu:2021:10.1117/1.JBO.26.3.036008,
author = {Wu, K-C and Sunwoo, J and Sheriff, F and Farzam, P and Farzam, PY and Orihuela-Espina, F and LaRose, SL and Monk, AD and Aziz-Sultan, MA and Patel, N and Vaitkevicius, H and Franceschini, MA},
doi = {10.1117/1.JBO.26.3.036008},
journal = {Journal of Biomedical Optics},
pages = {036008--1--036008--14},
title = {Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients},
url = {http://dx.doi.org/10.1117/1.JBO.26.3.036008},
volume = {26},
year = {2021}
}
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TY  - JOUR
AB  - SIGNIFICANCE: Intracranial pressure (ICP), variability in perfusion, and resulting ischemia are leading causes of secondary brain injury in patients treated in the neurointensive care unit. Continuous, accurate monitoring of cerebral blood flow (CBF) and ICP guide intervention and ultimately reduce morbidity and mortality. Currently, only invasive tools are used to monitor patients at high risk for intracranial hypertension. AIM: Diffuse correlation spectroscopy (DCS), a noninvasive near-infrared optical technique, is emerging as a possible method for continuous monitoring of CBF and critical closing pressure (CrCP or zero-flow pressure), a parameter directly related to ICP. APPROACH: We optimized DCS hardware and algorithms for the quantification of CrCP. Toward its clinical translation, we validated the DCS estimates of cerebral blood flow index (CBFi) and CrCP in ischemic stroke patients with respect to simultaneously acquired transcranial Doppler ultrasound (TCD) cerebral blood flow velocity (CBFV) and CrCP. RESULTS: We found CrCP derived from DCS and TCD were highly linearly correlated (ipsilateral R2  =  0.77, p  =  9  ×  10  -  7; contralateral R2  =  0.83, p  =  7  ×  10  -  8). We found weaker correlations between CBFi and CBFV (ipsilateral R2  =  0.25, p  =  0.03; contralateral R2  =  0.48, p  =  1  ×  10  -  3) probably due to the different vasculature measured. CONCLUSION: Our results suggest DCS is a valid alternative to TCD for continuous monitoring of CrCP.
AU  - Wu,K-C
AU  - Sunwoo,J
AU  - Sheriff,F
AU  - Farzam,P
AU  - Farzam,PY
AU  - Orihuela-Espina,F
AU  - LaRose,SL
AU  - Monk,AD
AU  - Aziz-Sultan,MA
AU  - Patel,N
AU  - Vaitkevicius,H
AU  - Franceschini,MA
DO  - 10.1117/1.JBO.26.3.036008
EP  - 1
PY  - 2021///
SN  - 1083-3668
SP  - 036008
TI  - Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients
T2  - Journal of Biomedical Optics
UR  - http://dx.doi.org/10.1117/1.JBO.26.3.036008
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33774980
UR  - https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-26/issue-03/036008/Validation-of-diffuse-correlation-spectroscopy-measures-of-critical-closing-pressure/10.1117/1.JBO.26.3.036008.full
UR  - http://hdl.handle.net/10044/1/88534
VL  - 26
ER  -
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