Imperial College London
Dr Felipe Orihuela-Espina

DrFelipeOrihuela-Espina

Faculty of Medicine, Department of Surgery & Cancer

Honorary Lecturer
 
 
 
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Publications

Citation

BibTex format

@article{Sunwoo:2022:10.1038/s41598-022-16499-3,
author = {Sunwoo, J and Zavriyev, A and Kaya, K and Martin, A and Munster, C and Steele, T and Cuddyer, D and Sheldon, Y and Orihuela-Espina, F and Herzberg, EM and Inder, T and Franceschini, MA and El-Dib, M},
doi = {10.1038/s41598-022-16499-3},
journal = {Scientific Reports},
pages = {1--12},
title = {Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns},
url = {http://dx.doi.org/10.1038/s41598-022-16499-3},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In premature infants with an extremely low gestational age (ELGA, < 29 weeks GA), dysregulated changes in cerebral blood flow (CBF) are among the major pathogenic factors leading to germinal matrix/intraventricular hemorrhage (GM/IVH). Continuous monitoring of CBF can guide interventions to minimize the risk of brain injury, but there are no clinically standard techniques or tools for its measurement. We report the feasibility of the continuous monitoring of CBF, including measures of autoregulation, via diffuse correlation spectroscopy (DCS) in ELGA infants using CBF variability and correlation with scalp blood flow (SBF, served as a surrogate measure of systemic perturbations). In nineteen ELGA infants (with 9 cases of GM/IVH) monitored for 6–24 h between days 2–5 of life, we found a strong correlation between CBF and SBF in severe IVH (Grade III or IV) and IVH diagnosed within 72 h of life, while CBF variability alone was not associated with IVH. The proposed method is potentially useful at the bedside for the prompt assessment of cerebral autoregulation and early identification of infants vulnerable to GM/IVH.
AU  - Sunwoo,J
AU  - Zavriyev,A
AU  - Kaya,K
AU  - Martin,A
AU  - Munster,C
AU  - Steele,T
AU  - Cuddyer,D
AU  - Sheldon,Y
AU  - Orihuela-Espina,F
AU  - Herzberg,EM
AU  - Inder,T
AU  - Franceschini,MA
AU  - El-Dib,M
DO  - 10.1038/s41598-022-16499-3
EP  - 12
PY  - 2022///
SN  - 2045-2322
SP  - 1
TI  - Diffuse correlation spectroscopy blood flow monitoring for intraventricular hemorrhage vulnerability in extremely low gestational age newborns
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-022-16499-3
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000831887000028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.nature.com/articles/s41598-022-16499-3
UR  - http://hdl.handle.net/10044/1/103838
VL  - 12
ER  -
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