Imperial College London
Portrait Picture

Dr Frédéric B. Piel

Faculty of Medicine, School of Public Health

Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 3346f.piel

 
 
//

Location

 

Praed StreetSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Faust:2020:10.1101/2020.10.21.344853,
author = {Faust, CL and Rangkuti, F and Preston, SG and Boyd, A and Flammer, P and Bia, B and Rose, NJ and Piel, FB and Smith, AL and Dobson, AP and Gupta, S and Penman, BS},
doi = {10.1101/2020.10.21.344853},
title = {Alpha globin variation in the long-tailed macaque suggests malaria selection},
url = {http://dx.doi.org/10.1101/2020.10.21.344853},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Human haemoglobin variants, such as sickle, confer protection against death from malaria; consequently, frequencies of such variants are often greatly elevated in humans from malaria endemic regions. Among non-human primates, the long-tailed macaque,<jats:italic>Macaca fascicularis</jats:italic>, also displays substantial haemoglobin variation. Almost all<jats:italic>M. fascicularis</jats:italic>haemoglobin variation is in the alpha globin chain, encoded by two linked genes:<jats:italic>HBA1</jats:italic>and<jats:italic>HBA2</jats:italic>. We demonstrate that alpha globin variation in<jats:italic>M. fascicularis</jats:italic>correlates with the strength of malaria selection. We identify a range of missense mutations in<jats:italic>M. fascicularis</jats:italic>alpha globin and demonstrate that some of these exhibit a striking<jats:italic>HBA1</jats:italic>or<jats:italic>HBA2</jats:italic>specificity, a pattern consistent with computational simulations of selection on genes exhibiting copy number variation. We propose that<jats:italic>M. fascicularis</jats:italic>accumulated amino acid substitutions in its alpha globin genes under malaria selection, in a process that closely mirrors, but does not entirely converge with, human malaria adaptation.</jats:p>
AU  - Faust,CL
AU  - Rangkuti,F
AU  - Preston,SG
AU  - Boyd,A
AU  - Flammer,P
AU  - Bia,B
AU  - Rose,NJ
AU  - Piel,FB
AU  - Smith,AL
AU  - Dobson,AP
AU  - Gupta,S
AU  - Penman,BS
DO  - 10.1101/2020.10.21.344853
PY  - 2020///
TI  - Alpha globin variation in the long-tailed macaque suggests malaria selection
UR  - http://dx.doi.org/10.1101/2020.10.21.344853
ER  -
Download