The project I am working on focuses on gaining structural and mechanistic insights into components of the Unfolded Protein Response (UPR). A better understanding of how the UPR signal is activated and modulated is indispensable for the development of more efficient cancer treatment.
My Post-Doc project focuses on the structural and functional study of c-IRE1α, the most conserved UPR sensor protein. Using a multidisciplinary approach and combining information from different techniques, such as X-ray crystallography, ITC, fluorescence, DLS and SEC-MALS I aim to picture the mechanism of IRE1α RNA binding and cleavage.
et al., 2021, Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer, Science Translational Medicine, Vol:13, ISSN:1946-6234
Cronin R, Brooke GN, Prischi F, 2021, The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance, Oncogene, Vol:40, ISSN:0950-9232, Pages:3775-3785
Prischi F, Filippakopoulos P, 2021, Editorial: Structural Studies of Protein Complexes in Signaling Pathways, Frontiers in Molecular Biosciences, Vol:8
et al., 2021, The Role of Ribosomal Protein S6 Kinases in Plant Homeostasis, Frontiers in Molecular Biosciences, Vol:8
Deganutti G, Prischi F, Reynolds CA, 2020, Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein, Journal of Computer-aided Molecular Design, Vol:35, ISSN:0920-654X, Pages:195-207