Imperial College London

DrFilippoPrischi

Faculty of Natural SciencesDepartment of Life Sciences

Visiting Researcher
 
 
 
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Contact

 

+44 (0)20 7594 5293f.prischi CV

 
 
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Location

 

Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Summary

The project I am working on focuses on gaining structural and mechanistic insights into components of the Unfolded Protein Response (UPR). A better understanding of how the UPR signal is activated and modulated is indispensable for the development of more efficient cancer treatment.

My Post-Doc project focuses on the structural and functional study of c-IRE1α, the most conserved UPR sensor protein. Using a multidisciplinary approach and combining information from different techniques, such as X-ray crystallography, ITC, fluorescence, DLS and SEC-MALS I aim to picture the mechanism of IRE1α RNA binding and cleavage.

Publications

Journals

Pardo O, Chrysostomou S, Roy R, et al., 2021, Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer, Science Translational Medicine, Vol:13, ISSN:1946-6234

Cronin R, Brooke GN, Prischi F, 2021, The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance, Oncogene, Vol:40, ISSN:0950-9232, Pages:3775-3785

Prischi F, Filippakopoulos P, 2021, Editorial: Structural Studies of Protein Complexes in Signaling Pathways, Frontiers in Molecular Biosciences, Vol:8

Obomighie I, Lapenas K, Murphy BE, et al., 2021, The Role of Ribosomal Protein S6 Kinases in Plant Homeostasis, Frontiers in Molecular Biosciences, Vol:8

Deganutti G, Prischi F, Reynolds CA, 2020, Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein, Journal of Computer-aided Molecular Design, Vol:35, ISSN:0920-654X, Pages:195-207

More Publications