Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Visiting Researcher



+44 (0)20 7594 5293f.prischi CV




Sir Ernst Chain BuildingSouth Kensington Campus





The project I am working on focuses on gaining structural and mechanistic insights into components of the Unfolded Protein Response (UPR). A better understanding of how the UPR signal is activated and modulated is indispensable for the development of more efficient cancer treatment.

My Post-Doc project focuses on the structural and functional study of c-IRE1α, the most conserved UPR sensor protein. Using a multidisciplinary approach and combining information from different techniques, such as X-ray crystallography, ITC, fluorescence, DLS and SEC-MALS I aim to picture the mechanism of IRE1α RNA binding and cleavage.



Galderisi S, Rossi M, Cicaloni V, et al., 2022, Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria, Archives of Biochemistry and Biophysics, Vol:717, ISSN:0003-9861

Pardo O, Chrysostomou S, Roy R, et al., 2021, Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer, Science Translational Medicine, Vol:13, ISSN:1946-6234

Cronin R, Brooke GN, Prischi F, 2021, The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance, Oncogene, Vol:40, ISSN:0950-9232, Pages:3775-3785

Prischi F, Filippakopoulos P, 2021, Editorial: Structural Studies of Protein Complexes in Signaling Pathways, Frontiers in Molecular Biosciences, Vol:8

Obomighie I, Lapenas K, Murphy BE, et al., 2021, The Role of Ribosomal Protein S6 Kinases in Plant Homeostasis, Frontiers in Molecular Biosciences, Vol:8

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