Imperial College London
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ProfessorFrederickTam

Faculty of Medicine, Department of Immunology and Inflammation

Ken and Mary Minton Chair of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3313 2354f.tam

 
 
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Location

 

9N, 15C, Commonwealth BuildingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chen:2021:10.1038/s41598-021-87684-z,
author = {Chen, C-H and Chen, C-Y and Yu, M-C and Fu, J-F and Hou, Y-C and Wang, I-K and Chih, Y-H and Weng, C-H and Huang, W-H and Hsu, C-W and Tam, FWK and Yen, T-H},
doi = {10.1038/s41598-021-87684-z},
journal = {Scientific Reports},
pages = {1--9},
title = {Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis.},
url = {http://dx.doi.org/10.1038/s41598-021-87684-z},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Although patients with diabetes mellitus mostly present with enlarged or normal-sized kidneys throughout their life, a small proportion of patients have small kidneys. This longitudinal study enrolled 83 diabetic patients treated with peritoneal dialysis (PD) between 2015 and 2019. Patients were stratified into two groups, those with enlarged or normal (n = 67) or small (n = 16) kidneys, based on their kidney sizes before dialysis. Patients with small kidney size were not only older (76.63 ± 10.63 vs. 68.03 ± 11.26 years, P = 0.007), suffered longer duration of diabetes mellitus (272.09 ± 305.09 vs. 151.44 ± 85.31 month, P = 0.006) and predominantly female (75.0 vs. 41.8%, P = 0.017), but also had lower serum levels of creatinine (9.63 ± 2.82 vs. 11.74 ± 3.32 mg/dL, P = 0.022) and albumin (3.23 ± 0.67 vs. 3.60 ± 0.47 g/dL, P = 0.010) than patients with enlarged or normal kidney size. At the end of analysis, 14 (16.9%) patients died. Patients with small kidney size demonstrated higher all-cause (50.0 vs. 9.0%, P < 0.001) and infection-related (43.8 vs. 7.5%, P < 0.001) mortality than patients with enlarged or normal kidney size. In a multivariate-logistic-regression model, small kidney size was a powerful predictor of mortality (odds ratio 6.452, 95% confidence interval 1.220-34.482, P = 0.028). Diabetic patients with small kidney size at the beginning of PD carry a substantial risk for mortality.
AU  - Chen,C-H
AU  - Chen,C-Y
AU  - Yu,M-C
AU  - Fu,J-F
AU  - Hou,Y-C
AU  - Wang,I-K
AU  - Chih,Y-H
AU  - Weng,C-H
AU  - Huang,W-H
AU  - Hsu,C-W
AU  - Tam,FWK
AU  - Yen,T-H
DO  - 10.1038/s41598-021-87684-z
EP  - 9
PY  - 2021///
SN  - 2045-2322
SP  - 1
TI  - Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis.
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-87684-z
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33859292
UR  - https://www.nature.com/articles/s41598-021-87684-z
UR  - http://hdl.handle.net/10044/1/88131
VL  - 11
ER  -
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