Imperial College London
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ProfessorFrederickTam

Faculty of Medicine, Department of Immunology and Inflammation

Ken and Mary Minton Chair of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3313 2354f.tam

 
 
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Location

 

9N, 15C, Commonwealth BuildingHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tam:2018:10.1038/s41598-017-18595-1,
author = {Tam, FWK and Montero, R and Herath, A and Qureshi, A and Esfandiari, E and Pusey, C and Frankel, A},
doi = {10.1038/s41598-017-18595-1},
journal = {Scientific Reports},
title = {Defining Phenotypes in Diabetic Nephropathy: a novel approach using a cross-sectional analysis of a single centre cohort.},
url = {http://dx.doi.org/10.1038/s41598-017-18595-1},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The global increase in Diabetes Mellitus (DM) has led to an increase in DM-Chronic Kidney Disease (DM-CKD). In this cross-sectional observational study we aimed to define phenotypes for patients with DM-CKD that in future may be used to individualise treatment We report 4 DM-CKD phenotypes in 220 patients recruited from Imperial College NHS Trust clinics from 2004–2012. A robust principal component analysis (PCA) was used to statistically determine clusters with phenotypically different patients. 163 patients with complete data sets were analysed: 77 with CKD and 86 with DM-CKD. Four different clusters were identified. Phenotypes 1 and 2 are entirely composed of patients with DM-CKD and phenotypes 3 and 4 are predominantly CKD (non-DM-CKD). Phenotype 1 depicts a cardiovascular phenotype; phenotype 2: microvascular complications with advanced DM-CKD; phenotype 3: advanced CKD with less anaemia, lower weight and HbA1c; phenotype 4: hypercholesteraemic, younger, less severe CKD. We are the first group to describe different phenotypes in DM-CKD using a PCA approach. Identification of phenotypic groups illustrates the differences and similarities that occur under the umbrella term of DM-CKD providing an opportunity to study phenotypes within these groups thereby facilitating development of precision/personalised targeted medicine.
AU  - Tam,FWK
AU  - Montero,R
AU  - Herath,A
AU  - Qureshi,A
AU  - Esfandiari,E
AU  - Pusey,C
AU  - Frankel,A
DO  - 10.1038/s41598-017-18595-1
PY  - 2018///
SN  - 2045-2322
TI  - Defining Phenotypes in Diabetic Nephropathy: a novel approach using a cross-sectional analysis of a single centre cohort.
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-017-18595-1
UR  - http://hdl.handle.net/10044/1/54995
VL  - 8
ER  -
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